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Statements

Subject Item
n2:RIV%2F00023752%3A_____%2F09%3A00000960%21RIV10-MZ0-00023752
rdf:type
skos:Concept n14:Vysledek
dcterms:description
RGS4 represents a positional and functional candidate gene for schizophrenia confirmed by several studies in independent samples. In a group of 63 patients with schizophrenia, we have genotyped four SNPs (1,4,7,18)which have previously been associated with schizophrenia, individually or as part of haplotype. We evaluated the influence of candidate SNPs on phenotypic characteristics and regional brain metabolism measured by 18FDG PET. Neuroimaging data were treated by SPM99. We found lower metabolism bilaterally in basal ganglia (p<=0.05, corrected) in the risky G-allele carriers in SNP 7. In SNP 1, the trend for lower metabolism associated with the G-allele in the right prefrontal cortex was detected (p<=0.001). The risky G-allele was connected with lower expression of negative symptoms (SNP7) and later onset of schizophrenia (SNP 7,18).Our results support the role of basal ganglia and the prefrontal cortex in the mechanism of how the RGS4 polymorphism influrences schizophrenia. We formulate th RGS4 represents a positional and functional candidate gene for schizophrenia confirmed by several studies in independent samples. In a group of 63 patients with schizophrenia, we have genotyped four SNPs (1,4,7,18)which have previously been associated with schizophrenia, individually or as part of haplotype. We evaluated the influence of candidate SNPs on phenotypic characteristics and regional brain metabolism measured by 18FDG PET. Neuroimaging data were treated by SPM99. We found lower metabolism bilaterally in basal ganglia (p<=0.05, corrected) in the risky G-allele carriers in SNP 7. In SNP 1, the trend for lower metabolism associated with the G-allele in the right prefrontal cortex was detected (p<=0.001). The risky G-allele was connected with lower expression of negative symptoms (SNP7) and later onset of schizophrenia (SNP 7,18).Our results support the role of basal ganglia and the prefrontal cortex in the mechanism of how the RGS4 polymorphism influrences schizophrenia. We formulate th
dcterms:title
The influence of polymorphism for gene RGS4 (Regulator of G-protein Signaling 4) on regional brain metabolism (18FDG PET) and phenotypic variables in schizophrenia The influence of polymorphism for gene RGS4 (Regulator of G-protein Signaling 4) on regional brain metabolism (18FDG PET) and phenotypic variables in schizophrenia
skos:prefLabel
The influence of polymorphism for gene RGS4 (Regulator of G-protein Signaling 4) on regional brain metabolism (18FDG PET) and phenotypic variables in schizophrenia The influence of polymorphism for gene RGS4 (Regulator of G-protein Signaling 4) on regional brain metabolism (18FDG PET) and phenotypic variables in schizophrenia
skos:notation
RIV/00023752:_____/09:00000960!RIV10-MZ0-00023752
n3:aktivita
n16:P
n3:aktivity
P(NR9324)
n3:cisloPeriodika
Suppl. 3
n3:dodaniDat
n7:2010
n3:domaciTvurceVysledku
n4:4489829 n4:3784355 n4:1371576 n4:7303505 n4:6339824 n4:3462080 n4:1965247 n4:8377146 n4:7625952
n3:druhVysledku
n15:J
n3:duvernostUdaju
n13:S
n3:entitaPredkladatele
n6:predkladatel
n3:idSjednocenehoVysledku
319315
n3:idVysledku
RIV/00023752:_____/09:00000960
n3:jazykVysledku
n8:eng
n3:klicovaSlova
RGS4; schizophrenia; phenotypes; metabolism; 18FDG PET
n3:klicoveSlovo
n11:phenotypes n11:RGS4 n11:metabolism n11:18FDG%20PET n11:schizophrenia
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[03243796A4DC]
n3:nazevZdroje
Psychiatrie
n3:obor
n9:FL
n3:pocetDomacichTvurcuVysledku
9
n3:pocetTvurcuVysledku
10
n3:projekt
n17:NR9324
n3:rokUplatneniVysledku
n7:2009
n3:svazekPeriodika
13
n3:tvurceVysledku
Bubeníková-Valešová, Věra Minárik, Marek Španiel, Filip Novák, Tomáš Höschl, Cyril Horáček, Jiří Brunovský, Martin Páleníček, Tomáš Vrajová, Monika Mohr, Pavel
s:issn
1211-7579
s:numberOfPages
5