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Statements

Subject Item
n2:RIV%2F00023752%3A_____%2F09%3A00000950%21RIV10-MZ0-00023752
rdf:type
n5:Vysledek skos:Concept
dcterms:description
The amygdala plays an important role in the regulation of emotions and has been implicated in the pathophysiology of mood disorders. Studies of amygdala volumes in mood disorders have been conflicting, with findings of increased, decreased and unchanged amygdala volumes in patients relative to controls. We present the largest meta-analysis of amygdala volumes in mood disorders and the first one to investigate modifying effects of clinical, demographic and methodological variables. METHODS: We reviewed 40 magnetic resonance imaging studies investigating amygdala volumes in patients with unipolar or bipolar disorders. For meta-analysis we used standardized differences in means (SDM) and random effect models. In the search for sources of heterogeneity, we subdivided the studies based on diagnosis, setting, age, medication status, sex, duration of illness, slice thickness, interrater reliability of tracing and anatomical definitions used. RESULTS: The volumes of the left and right amygdala in bipolar (N= The amygdala plays an important role in the regulation of emotions and has been implicated in the pathophysiology of mood disorders. Studies of amygdala volumes in mood disorders have been conflicting, with findings of increased, decreased and unchanged amygdala volumes in patients relative to controls. We present the largest meta-analysis of amygdala volumes in mood disorders and the first one to investigate modifying effects of clinical, demographic and methodological variables. METHODS: We reviewed 40 magnetic resonance imaging studies investigating amygdala volumes in patients with unipolar or bipolar disorders. For meta-analysis we used standardized differences in means (SDM) and random effect models. In the search for sources of heterogeneity, we subdivided the studies based on diagnosis, setting, age, medication status, sex, duration of illness, slice thickness, interrater reliability of tracing and anatomical definitions used. RESULTS: The volumes of the left and right amygdala in bipolar (N=
dcterms:title
Amygdala volumes in mood disorders - meta-analysis of magnetic resonance volumetry studies Amygdala volumes in mood disorders - meta-analysis of magnetic resonance volumetry studies
skos:prefLabel
Amygdala volumes in mood disorders - meta-analysis of magnetic resonance volumetry studies Amygdala volumes in mood disorders - meta-analysis of magnetic resonance volumetry studies
skos:notation
RIV/00023752:_____/09:00000950!RIV10-MZ0-00023752
n3:aktivita
n15:V n15:P
n3:aktivity
P(NR8786), V
n3:cisloPeriodika
3
n3:dodaniDat
n12:2010
n3:domaciTvurceVysledku
n6:2625032 n6:2224151 n6:9789669 n6:1371576
n3:druhVysledku
n17:J
n3:duvernostUdaju
n13:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
302668
n3:idVysledku
RIV/00023752:_____/09:00000950
n3:jazykVysledku
n4:eng
n3:klicovaSlova
bipolar disorder; unipolar depression; meta-analysis; amygdala
n3:klicoveSlovo
n9:unipolar%20depression n9:meta-analysis n9:amygdala n9:bipolar%20disorder
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[E10B27987D2C]
n3:nazevZdroje
Journal of Affective Disorders
n3:obor
n7:FL
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
6
n3:projekt
n14:NR8786
n3:rokUplatneniVysledku
n12:2009
n3:svazekPeriodika
115
n3:tvurceVysledku
Höschl, Cyril Alda, M. Kožený, Jiří Hájek, Tomáš Kopeček, Miloslav Gunde, E.
n3:wos
000266347600014
s:issn
0165-0327
s:numberOfPages
6