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Statements

Subject Item
n2:RIV%2F00023752%3A_____%2F09%3A00000942%21RIV10-MZ0-00023752
rdf:type
n5:Vysledek skos:Concept
dcterms:description
OBJECTIVE: The aim of the study was to assess structural changes in gray matter (GM) volume and fractional anisotropy (FA) in patients with Alzheimer`s disease (AD) compared to control subjects using Voxel-Based Morphometry (VBM). Fractional anisotropy in the corpus callosum of both groups was also calculated using ROI analysis. METHODS: Twenty-one patients and twenty-three control subjects underwent MRI examination using T1-weighted 3D MPRAGE sequence and diffusion spin-echo echo-planar imaging sequence in six directions. Structural MRI analyses for GM volume and FA were performed using an optimized VBM protocol implemented in SPM5. The influence of age and Mini-Mental State Examination (MMSE) was dealt with multiple regression analysis either for the whole group or for AD patients and controls separately. RESULTS: Patients showed significant reduction of GM volume mainly in the temporal lobes. In AD patients, no correlation was observed between GM volume and age or MMSE. FA was reduced in AD patient OBJECTIVE: The aim of the study was to assess structural changes in gray matter (GM) volume and fractional anisotropy (FA) in patients with Alzheimer`s disease (AD) compared to control subjects using Voxel-Based Morphometry (VBM). Fractional anisotropy in the corpus callosum of both groups was also calculated using ROI analysis. METHODS: Twenty-one patients and twenty-three control subjects underwent MRI examination using T1-weighted 3D MPRAGE sequence and diffusion spin-echo echo-planar imaging sequence in six directions. Structural MRI analyses for GM volume and FA were performed using an optimized VBM protocol implemented in SPM5. The influence of age and Mini-Mental State Examination (MMSE) was dealt with multiple regression analysis either for the whole group or for AD patients and controls separately. RESULTS: Patients showed significant reduction of GM volume mainly in the temporal lobes. In AD patients, no correlation was observed between GM volume and age or MMSE. FA was reduced in AD patient
dcterms:title
Combination of voxel based morphometry and diffusion tensor imaging in patients with Alzheimer`s disease Combination of voxel based morphometry and diffusion tensor imaging in patients with Alzheimer`s disease
skos:prefLabel
Combination of voxel based morphometry and diffusion tensor imaging in patients with Alzheimer`s disease Combination of voxel based morphometry and diffusion tensor imaging in patients with Alzheimer`s disease
skos:notation
RIV/00023752:_____/09:00000942!RIV10-MZ0-00023752
n3:aktivita
n14:S n14:P n14:Z
n3:aktivity
P(1A8600), P(1M0517), P(NR8792), S, Z(MZ0IKEM2005), Z(MZ0PCP2005)
n3:cisloPeriodika
1
n3:dodaniDat
n13:2010
n3:domaciTvurceVysledku
n6:1787977 n6:3784355 n6:4549600 n6:6339824
n3:druhVysledku
n11:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
307534
n3:idVysledku
RIV/00023752:_____/09:00000942
n3:jazykVysledku
n4:eng
n3:klicovaSlova
Alzheimer`s disease; voxel-based morphometry; diffusion tensor imaging; MRI; white matter; grey matter; fractional anisotropy; age
n3:klicoveSlovo
n7:Alzheimer%60s%20disease n7:voxel-based%20morphometry n7:MRI n7:age n7:diffusion%20tensor%20imaging n7:white%20matter n7:fractional%20anisotropy n7:grey%20matter
n3:kodStatuVydavatele
SE - Švédské království
n3:kontrolniKodProRIV
[0A6A6A888546]
n3:nazevZdroje
Neuroendocrinology Letters
n3:obor
n16:FL
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
7
n3:projekt
n9:NR8792 n9:1M0517 n9:1A8600
n3:rokUplatneniVysledku
n13:2009
n3:svazekPeriodika
30
n3:tvurceVysledku
Ibrahim, I. Řípová, Daniela Hájek, M. Brunovský, Martin Tintěra, Jaroslav Bartoš, Aleš Horáček, Jiří
n3:wos
000265426800011
n3:zamer
n18:MZ0IKEM2005 n18:MZ0PCP2005
s:issn
0172-780X
s:numberOfPages
7