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Statements

Subject Item
n2:RIV%2F00023752%3A_____%2F05%3A00000883%21RIV09-MZ0-00023752
rdf:type
n9:Vysledek skos:Concept
dcterms:description
Článek na základě neurozobrazovacích studií nepostižených příbuzných bipolárních pacientů, pediatrické bipolární poruchy, pacientů s první epizodou a pacientů s rodinnou anamnézou bipolární poruchy pátrá po neuroanatomických změnách použitelných jako biologické markery pro bipolární poruchy. OBJECTIVE: Neuroimaging studies show structural brain abnormalities in bipolar patients. Some of the abnormalities may represent biological risk factors conveying vulnerability for the disease. This paper aims to identify neuroanatomical risk factors for bipolar disorder (BD). METHODS: We reviewed magnetic resonance imaging (MRI) findings in populations in which the effects of the disease or treatment are minimal or where the chances of finding genetically coded risk factors shared within the families are increased. Such populations include unaffected relatives of bipolar patients, first-episode patients, children or adolescents with BD and patients with familial BD. RESULTS: MEDLINE search revealed 30 relevant scientific papers. Abnormalities in the volume of the striatum, left hemispheric white matter, thalamus and anterior cingulate as well as quantitative MRI signal hyperintensities were identified already in unaffected relatives of bipolar patients. Subjects in the early stages of the disease sho OBJECTIVE: Neuroimaging studies show structural brain abnormalities in bipolar patients. Some of the abnormalities may represent biological risk factors conveying vulnerability for the disease. This paper aims to identify neuroanatomical risk factors for bipolar disorder (BD). METHODS: We reviewed magnetic resonance imaging (MRI) findings in populations in which the effects of the disease or treatment are minimal or where the chances of finding genetically coded risk factors shared within the families are increased. Such populations include unaffected relatives of bipolar patients, first-episode patients, children or adolescents with BD and patients with familial BD. RESULTS: MEDLINE search revealed 30 relevant scientific papers. Abnormalities in the volume of the striatum, left hemispheric white matter, thalamus and anterior cingulate as well as quantitative MRI signal hyperintensities were identified already in unaffected relatives of bipolar patients. Subjects in the early stages of the disease sho
dcterms:title
Neuroanatomické změny jako rizikové faktory bipolární poruchy Neuroanatomical abnormalities as risk factors for bipolar disorder Neuroanatomical abnormalities as risk factors for bipolar disorder
skos:prefLabel
Neuroanatomical abnormalities as risk factors for bipolar disorder Neuroanatomické změny jako rizikové faktory bipolární poruchy Neuroanatomical abnormalities as risk factors for bipolar disorder
skos:notation
RIV/00023752:_____/05:00000883!RIV09-MZ0-00023752
n3:aktivita
n11:S n11:N
n3:aktivity
N, S
n3:cisloPeriodika
5
n3:dodaniDat
n13:2009
n3:domaciTvurceVysledku
n16:2224151
n3:druhVysledku
n12:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
532562
n3:idVysledku
RIV/00023752:_____/05:00000883
n3:jazykVysledku
n4:eng
n3:klicovaSlova
adolescents; amygdala; bipolar disorder; children; hippocampus; magnetic resonance imaging; striatum; subgenual prefrontal cortes
n3:klicoveSlovo
n7:adolescents n7:hippocampus n7:amygdala n7:striatum n7:subgenual%20prefrontal%20cortes n7:children n7:magnetic%20resonance%20imaging n7:bipolar%20disorder
n3:kodStatuVydavatele
DK - Dánské království
n3:kontrolniKodProRIV
[A9FB5D2F1A79]
n3:nazevZdroje
Bipolar Disorders
n3:obor
n8:FL
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
3
n3:rokUplatneniVysledku
n13:2005
n3:svazekPeriodika
7
n3:tvurceVysledku
Hájek, Tomáš Alda, M. Carrey, N.
s:issn
1398-5647
s:numberOfPages
11