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Statements

Subject Item
n2:RIV%2F00023752%3A_____%2F05%3A00000476%21RIV06-MZ0-00023752
rdf:type
skos:Concept n9:Vysledek
dcterms:description
Dizocilpine (MK-801; 0,3 mg/kg i.p.) - induced disruption in prepulse inhibition of the acoustic startle response (PPI) can be preferentially restored by %22atypical%22 antipsychotics. In contrast, some finding indicate that not all of the %22atypical%22 antipsychotics, such as clozapine and risperidone, are effective in restoring the NMDA antagonist-induced deficits in PPI. In our study, we evaluated the effect of four different %22atypical%22 antipsychotic drugs on deficits in PPI induced by MK-801. Zotepine and risperidone have high affinities to D2-like and 5-HT2A receptors, while clozapine and olanzapine have multipharmacological profiles with the highest affinities to serotonin 5-HT1A,2A/2C receptors and muscarinic receptors. Results have shown that MK-801 disrupted PPI and increased the ASR in rats. Our results showed no effect of zotepine (1 and 2 mg/kg) and risperidone (0,1 and 1 mg/kg) on disrupted PPI by MK-801. Administration of clozapine (5 and 10 mg/kg) and olanzapine Dizocilpine (MK-801; 0,3 mg/kg i.p.) - induced disruption in prepulse inhibition of the acoustic startle response (PPI) can be preferentially restored by %22atypical%22 antipsychotics. In contrast, some finding indicate that not all of the %22atypical%22 antipsychotics, such as clozapine and risperidone, are effective in restoring the NMDA antagonist-induced deficits in PPI. In our study, we evaluated the effect of four different %22atypical%22 antipsychotic drugs on deficits in PPI induced by MK-801. Zotepine and risperidone have high affinities to D2-like and 5-HT2A receptors, while clozapine and olanzapine have multipharmacological profiles with the highest affinities to serotonin 5-HT1A,2A/2C receptors and muscarinic receptors. Results have shown that MK-801 disrupted PPI and increased the ASR in rats. Our results showed no effect of zotepine (1 and 2 mg/kg) and risperidone (0,1 and 1 mg/kg) on disrupted PPI by MK-801. Administration of clozapine (5 and 10 mg/kg) and olanzapine Aplikace dizocilpinu (MK-801;0,3 mg/kg i.p.) poškozuje prepulzní inhibici akustické úlekové reakce (PPI). Deficit PPI navozený MK-801 je přednostně obnoven %22atypickými%22 antipsychotiky. Avšak některé nálezy ukazují, že ne všechna %22atypická%22 antipsychotika, jako je clozapin a risperidon jsou účinný v obnovení PPI. V naší studii jsme vyhodnotili účinek čtyř rozdílných %22atypických%22 antipsychotik na deficit v PPI navozený aplikací MK-801. Zotepin a risperidon vykazují vysokou afinitu k D2-like a 5-HT2A receptorům, ačkoliv clozapin a olanzapin mají multifarmakologický profil s vysokou afinitou k serotoninovým 5-HT1A a 5-HT2A/2C receptorům a muskarinovým receptorům. Výsledky ukazují, že MK-801 poškozuje PPI a zvyšuje úlekovou reakci u potkanů. Nebyl pozorován žádný efekt zotepinu (1 a 2 mg/kg) a risperidonu (0,1 a 1 mg/kg) na deficit v PPI navozený MK-801. Podání clozapinu (5 a 10 mg/kg) a olanzapinu (2,5 a 5 mg/kg) obnovilo PPI poškozené MK-801. Podání clozapinu v dávce 5 mg/kg
dcterms:title
The effect of zotepine, risperidone, clozapine and olanzapine on MK-801-disrupted sensorimotor gating The effect of zotepine, risperidone, clozapine and olanzapine on MK-801-disrupted sensorimotor gating The effect of zotepine, risperidone, clozapine and olanzapine on MK-801-disrupted sensorimotor gating
skos:prefLabel
The effect of zotepine, risperidone, clozapine and olanzapine on MK-801-disrupted sensorimotor gating The effect of zotepine, risperidone, clozapine and olanzapine on MK-801-disrupted sensorimotor gating The effect of zotepine, risperidone, clozapine and olanzapine on MK-801-disrupted sensorimotor gating
skos:notation
RIV/00023752:_____/05:00000476!RIV06-MZ0-00023752
n3:strany
591-596
n3:aktivita
n5:P
n3:aktivity
P(NL7684)
n3:cisloPeriodika
4
n3:dodaniDat
n17:2006
n3:domaciTvurceVysledku
Dockery, Colleen Anne n10:7303505 n10:6339824 n10:4489829
n3:druhVysledku
n7:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n12:predkladatel
n3:idSjednocenehoVysledku
519516
n3:idVysledku
RIV/00023752:_____/05:00000476
n3:jazykVysledku
n8:eng
n3:klicovaSlova
antipsychotics; prepulse inhiibiton of the startle response; rats; MK-801
n3:klicoveSlovo
n11:MK-801 n11:antipsychotics n11:prepulse%20inhiibiton%20of%20the%20startle%20response n11:rats
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[2129E3C233F1]
n3:nazevZdroje
Pharmacology Biochemistry and Behavior
n3:obor
n14:FH
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
5
n3:projekt
n16:NL7684
n3:rokUplatneniVysledku
n17:2005
n3:svazekPeriodika
80
n3:tvurceVysledku
Dockery, Colleen Anne Votava, M. Páleníček, Tomáš Horáček, Jiří Bubeníková, Věra
s:issn
0091-3057
s:numberOfPages
6