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Statements

Subject Item
n2:RIV%2F00023752%3A_____%2F03%3A00000296%21RIV%2F2004%2FMSM%2FL28004%2FN
rdf:type
n5:Vysledek skos:Concept
dcterms:description
Lithium is a potent noncompetitive inhibitor of inositol monophosphatases, enzymes involved in phosphoinositide (PI) and inositol phosphate metabolism. A critical component of the PI pathway is phosphatidylinositol 4,5-bisphosphate (Ptdlns(4,5)P-2), which is hydrolyzed to second messengers and has a direct role in synaptic vesicle function. Interestingly, a number of genes involved in the synthesis and dephosphorylation of Ptdlns(4,5)P-2 are found in regions of the genome previously mapped in bipolar disorder (BD) including 10p12, 21q22, and 22q11, among others. Some of these regions overlap with loci mapped in schizophrenia (SZ). One gene involved in PI metabolism that maps to a region of interest is 10p12-linked PIP5K2A, a member of the phosphatidylinositol 4-phosphate 5-kinase family. Polymorphism screening revealed the existence of an imperfect CT repeat polymorphism located near the exon 9-intron 9 splice donor site. A modest difference was found in the distribution of alleles from this highly po Lithium is a potent noncompetitive inhibitor of inositol monophosphatases, enzymes involved in phosphoinositide (PI) and inositol phosphate metabolism. A critical component of the PI pathway is phosphatidylinositol 4,5-bisphosphate (Ptdlns(4,5)P-2), which is hydrolyzed to second messengers and has a direct role in synaptic vesicle function. Interestingly, a number of genes involved in the synthesis and dephosphorylation of Ptdlns(4,5)P-2 are found in regions of the genome previously mapped in bipolar disorder (BD) including 10p12, 21q22, and 22q11, among others. Some of these regions overlap with loci mapped in schizophrenia (SZ). One gene involved in PI metabolism that maps to a region of interest is 10p12-linked PIP5K2A, a member of the phosphatidylinositol 4-phosphate 5-kinase family. Polymorphism screening revealed the existence of an imperfect CT repeat polymorphism located near the exon 9-intron 9 splice donor site. A modest difference was found in the distribution of alleles from this highly po
dcterms:title
Polymorphism screening of PIP5K2A: A candidate gene for chromosome 10p-linked psychiatric disorders Polymorphism screening of PIP5K2A: A candidate gene for chromosome 10p-linked psychiatric disorders
skos:prefLabel
Polymorphism screening of PIP5K2A: A candidate gene for chromosome 10p-linked psychiatric disorders Polymorphism screening of PIP5K2A: A candidate gene for chromosome 10p-linked psychiatric disorders
skos:notation
RIV/00023752:_____/03:00000296!RIV/2004/MSM/L28004/N
n3:strany
50-58
n3:aktivita
n15:Z
n3:aktivity
Z(MSM 111100001)
n3:cisloPeriodika
1
n3:dodaniDat
n14:2004
n3:domaciTvurceVysledku
n6:8663807
n3:druhVysledku
n10:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n9:predkladatel
n3:idSjednocenehoVysledku
621551
n3:idVysledku
RIV/00023752:_____/03:00000296
n3:jazykVysledku
n7:eng
n3:klicovaSlova
candidate gene; PIP2; synaptic vesicle; exocytosis; endocytosis
n3:klicoveSlovo
n4:exocytosis n4:candidate%20gene n4:PIP2 n4:synaptic%20vesicle n4:endocytosis
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[F8151A6628A3]
n3:nazevZdroje
American Journal of Medical Genetics. Part B-Neuropsychiatric Genetics
n3:obor
n17:FH
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
10
n3:pocetUcastnikuAkce
0
n3:pocetZahranicnichUcastnikuAkce
0
n3:rokUplatneniVysledku
n14:2003
n3:svazekPeriodika
123B
n3:tvurceVysledku
Paclt, I. Papolos, D. F. Vevera, J. Saito, T. Stopková, Pavla Stryjer, R. Strous, R. D. Žukov, I. Fann, C. S. J. Lachman, H. M.
n3:zamer
n11:MSM%20111100001
s:issn
0148-7299
s:numberOfPages
9