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Statements

Subject Item
n2:RIV%2F00023752%3A_____%2F03%3A00000282%21RIV%2F2004%2FMSM%2FL28004%2FN
rdf:type
n8:Vysledek skos:Concept
dcterms:description
Haloperidol is a potent D2 antagonist, belonging to the so-called group of typical antipsychotics. It is effectively used in the treatment of schizophrenia. In our experimental setting we have evaluated the effects of haloperidol on psychosis-like reaction induced by non-competitive NMDA glutamate receptor antagonist, MK-801. We have monitored the locomotor reaction of rats in the open field, whereas we have targeted to evaluate the effects of haloperidol on hyperlocomotion induced by MK-801. We have found that MK-801 induced hyperolocomotor reaction was efficiently diminished by administration of haloperidol in a dose dependent manner. In our experimental setting we conclude that haloperidol was effective in counteracting MK-801 induced hyperlocomotion. Inasmuch as this model serves as a model of psychosis, we can extrapolate that haloperidol has an antipsychotic effect. Haloperidol is a potent D2 antagonist, belonging to the so-called group of typical antipsychotics. It is effectively used in the treatment of schizophrenia. In our experimental setting we have evaluated the effects of haloperidol on psychosis-like reaction induced by non-competitive NMDA glutamate receptor antagonist, MK-801. We have monitored the locomotor reaction of rats in the open field, whereas we have targeted to evaluate the effects of haloperidol on hyperlocomotion induced by MK-801. We have found that MK-801 induced hyperolocomotor reaction was efficiently diminished by administration of haloperidol in a dose dependent manner. In our experimental setting we conclude that haloperidol was effective in counteracting MK-801 induced hyperlocomotion. Inasmuch as this model serves as a model of psychosis, we can extrapolate that haloperidol has an antipsychotic effect.
dcterms:title
Effects of haloperidol on locomotion in animal model of schizophrenia induced by MK-801 Effects of haloperidol on locomotion in animal model of schizophrenia induced by MK-801
skos:prefLabel
Effects of haloperidol on locomotion in animal model of schizophrenia induced by MK-801 Effects of haloperidol on locomotion in animal model of schizophrenia induced by MK-801
skos:notation
RIV/00023752:_____/03:00000282!RIV/2004/MSM/L28004/N
n3:strany
50-54
n3:aktivita
n17:P
n3:aktivity
P(LN00B122), P(NF6033), P(NL7684)
n3:cisloPeriodika
Suppl. 3
n3:dodaniDat
n9:2004
n3:domaciTvurceVysledku
n13:4489829 n13:7303505 n13:6339824
n3:druhVysledku
n16:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n5:predkladatel
n3:idSjednocenehoVysledku
605298
n3:idVysledku
RIV/00023752:_____/03:00000282
n3:jazykVysledku
n10:eng
n3:klicovaSlova
haloperidol; MK-801; schizophrenia; animal model; locomotion; antipsychotics; dopamine
n3:klicoveSlovo
n11:dopamine n11:locomotion n11:MK-801 n11:schizophrenia n11:haloperidol n11:antipsychotics n11:animal%20model
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[F0FB7BCB00AE]
n3:nazevZdroje
Psychiatrie
n3:obor
n12:FH
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
3
n3:pocetUcastnikuAkce
0
n3:pocetZahranicnichUcastnikuAkce
0
n3:projekt
n4:NF6033 n4:LN00B122 n4:NL7684
n3:rokUplatneniVysledku
n9:2003
n3:svazekPeriodika
7
n3:tvurceVysledku
Páleníček, Tomáš Horáček, Jiří Bubeníková, Věra
s:issn
1211-7579
s:numberOfPages
5