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Statements

Subject Item
n2:RIV%2F00023752%3A_____%2F01%3A00000192%21RIV%2F2002%2FMZ0%2FL28002%2FN
rdf:type
n15:Vysledek skos:Concept
dcterms:description
Senile dementia of Alzheimer`s type (AD) is commonly characterized as a neurodegenerative disorder, which exhibits gradual changes of consciousness, loss of memory, perception and orientation as well as loss of personality and intellect. AD prevalence increases dramatically with age and is the fourth cause of death in Europe and in the USA. Currently, there are no available biological markers, which gives clinicians no other alternative than to rely upon clinical diagnosis by exclusion. There is no assay of objective ante mortem biochemical phenomena that relate to the pathophysiology of this disease. The pathophysiology of AD is connected with alterations in neurotransmission, plaque formation, cytoskeletal abnormalities and disturbances of calcium homeostasis. The search for a test, which is non-invasive, simple, cheap and user-friendly, should be directed at accessible body fluids. Only abnormalities replicated in large series across different laboratories fulfilling the criteria for a biological m Senile dementia of Alzheimer`s type (AD) is commonly characterized as a neurodegenerative disorder, which exhibits gradual changes of consciousness, loss of memory, perception and orientation as well as loss of personality and intellect. AD prevalence increases dramatically with age and is the fourth cause of death in Europe and in the USA. Currently, there are no available biological markers, which gives clinicians no other alternative than to rely upon clinical diagnosis by exclusion. There is no assay of objective ante mortem biochemical phenomena that relate to the pathophysiology of this disease. The pathophysiology of AD is connected with alterations in neurotransmission, plaque formation, cytoskeletal abnormalities and disturbances of calcium homeostasis. The search for a test, which is non-invasive, simple, cheap and user-friendly, should be directed at accessible body fluids. Only abnormalities replicated in large series across different laboratories fulfilling the criteria for a biological m
dcterms:title
An ideal biological marker of Alzheimer`s disease: dream or reality? An ideal biological marker of Alzheimer`s disease: dream or reality?
skos:prefLabel
An ideal biological marker of Alzheimer`s disease: dream or reality? An ideal biological marker of Alzheimer`s disease: dream or reality?
skos:notation
RIV/00023752:_____/01:00000192!RIV/2002/MZ0/L28002/N
n3:strany
119-129
n3:aktivita
n11:Z n11:P
n3:aktivity
P(NG15), Z(MSM 113100003)
n3:cisloPeriodika
2
n3:dodaniDat
n14:2002
n3:domaciTvurceVysledku
n17:4549600
n3:druhVysledku
n13:J
n3:duvernostUdaju
n10:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
673005
n3:idVysledku
RIV/00023752:_____/01:00000192
n3:jazykVysledku
n4:eng
n3:klicovaSlova
Alzheimer`s disease, biological peripheral marker, b-amyloid, protein t, review
n3:klicoveSlovo
n7:review n7:protein%20t n7:b-amyloid n7:Alzheimer%60s%20disease n7:biological%20peripheral%20marker
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[D095CABBEF24]
n3:nazevZdroje
Physiological Research
n3:obor
n12:FH
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
2
n3:pocetUcastnikuAkce
0
n3:pocetZahranicnichUcastnikuAkce
0
n3:projekt
n8:NG15
n3:rokUplatneniVysledku
n14:2001
n3:svazekPeriodika
50
n3:tvurceVysledku
Strunecká, Anna Řípová, Daniela
n3:zamer
n9:MSM%20113100003
s:issn
0862-8408
s:numberOfPages
11