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Statements

Subject Item
n2:RIV%2F00023752%3A_____%2F01%3A00000162%21RIV%2F2002%2FMSM%2FL28002%2FN
rdf:type
skos:Concept n14:Vysledek
dcterms:description
N-Acetyl-aspartyl-glutamate (NAAG), the most abundant neuroactive peptide in the mammalian CNS, has only two known specific targets in brain tissue: ionotropic glutamate receptor of N-methyl-D-aspartate type and metabotropic G-protein linked glutamate receptors of class II. Several observations have pointed to a nexus between changes in the level of NAAG in brain and the development of neurodegenerative and mental diseases. The precise role of NAAG in neurodegeneration (or in healthy brain tissue) is, however, less clear. There could be a fine balance between the neuroprotective and neurotoxic actions of NAAG, depending on which one of the two populations of receptors targeted by NAAG is more active. The decisive factor could be the extracellular concentration (rather than overall tissue level) of NAAG and this can be manipulated in an animal model in vivo. Therefore, we have been using quantitative morphology, electron microscopy and molecular biological techniques to study and characterize the neuro N-Acetyl-aspartyl-glutamate (NAAG), the most abundant neuroactive peptide in the mammalian CNS, has only two known specific targets in brain tissue: ionotropic glutamate receptor of N-methyl-D-aspartate type and metabotropic G-protein linked glutamate receptors of class II. Several observations have pointed to a nexus between changes in the level of NAAG in brain and the development of neurodegenerative and mental diseases. The precise role of NAAG in neurodegeneration (or in healthy brain tissue) is, however, less clear. There could be a fine balance between the neuroprotective and neurotoxic actions of NAAG, depending on which one of the two populations of receptors targeted by NAAG is more active. The decisive factor could be the extracellular concentration (rather than overall tissue level) of NAAG and this can be manipulated in an animal model in vivo. Therefore, we have been using quantitative morphology, electron microscopy and molecular biological techniques to study and characterize the neuro
dcterms:title
Characterisation of hippocampal neurodegeneration after intracerebroventricular administration of n-acetyl-aspartyl-glutamate Characterisation of hippocampal neurodegeneration after intracerebroventricular administration of n-acetyl-aspartyl-glutamate
skos:prefLabel
Characterisation of hippocampal neurodegeneration after intracerebroventricular administration of n-acetyl-aspartyl-glutamate Characterisation of hippocampal neurodegeneration after intracerebroventricular administration of n-acetyl-aspartyl-glutamate
skos:notation
RIV/00023752:_____/01:00000162!RIV/2002/MSM/L28002/N
n4:strany
102-104
n4:aktivita
n12:P
n4:aktivity
P(LN00B122)
n4:cisloPeriodika
Suppl. 2
n4:dodaniDat
n7:2002
n4:domaciTvurceVysledku
n11:4489829 n11:6507026
n4:druhVysledku
n9:J
n4:duvernostUdaju
n16:S
n4:entitaPredkladatele
n10:predkladatel
n4:idSjednocenehoVysledku
675356
n4:idVysledku
RIV/00023752:_____/01:00000162
n4:jazykVysledku
n5:eng
n4:klicovaSlova
N-Acetyl-aspartyl-glutamate, glutamate, N-acetyl-aspartate, neurodegeneration, necrosis, apoptosis
n4:klicoveSlovo
n6:neurodegeneration n6:apoptosis n6:glutamate n6:N-acetyl-aspartate n6:N-Acetyl-aspartyl-glutamate n6:necrosis
n4:kodStatuVydavatele
CZ - Česká republika
n4:kontrolniKodProRIV
[B3D83A44851A]
n4:nazevZdroje
Psychiatrie
n4:obor
n13:FH
n4:pocetDomacichTvurcuVysledku
2
n4:pocetTvurcuVysledku
4
n4:pocetUcastnikuAkce
0
n4:pocetZahranicnichUcastnikuAkce
0
n4:projekt
n17:LN00B122
n4:rokUplatneniVysledku
n7:2001
n4:svazekPeriodika
5
n4:tvurceVysledku
Bubeníková, Věra Pliss, Lioudmila Balcar, Vladimír Joseph Šťastný, František
s:issn
1211-7579
s:numberOfPages
3