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Statements

Subject Item
n2:RIV%2F00023736%3A_____%2F13%3A00010741%21RIV14-MZ0-00023736
rdf:type
n7:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1074/jbc.M113.471573
dcterms:description
Hepcidin is the hormone of iron metabolism that is bound by alpha2-macroglobulin (alpha2M) and its activated counterpart (alpha2M-MA). Serum iron is reduced to a greater extent in mice treated with alpha2Mhepcidin or alpha2M-MAhepcidin relative to unbound hepcidin. Alpha2M retards hepcidin excretion by the kidney, increasing its efficacy. These results are important for understanding hepcidin transport and detection in blood. Hepcidin is the hormone of iron metabolism that is bound by alpha2-macroglobulin (alpha2M) and its activated counterpart (alpha2M-MA). Serum iron is reduced to a greater extent in mice treated with alpha2Mhepcidin or alpha2M-MAhepcidin relative to unbound hepcidin. Alpha2M retards hepcidin excretion by the kidney, increasing its efficacy. These results are important for understanding hepcidin transport and detection in blood.
dcterms:title
Hepcidin bound to alpha(2)-macroglobulin reduces ferroportin-1 expression and enhances its activity at reducing serum iron levels Hepcidin bound to alpha(2)-macroglobulin reduces ferroportin-1 expression and enhances its activity at reducing serum iron levels
skos:prefLabel
Hepcidin bound to alpha(2)-macroglobulin reduces ferroportin-1 expression and enhances its activity at reducing serum iron levels Hepcidin bound to alpha(2)-macroglobulin reduces ferroportin-1 expression and enhances its activity at reducing serum iron levels
skos:notation
RIV/00023736:_____/13:00010741!RIV14-MZ0-00023736
n7:predkladatel
n8:ico%3A00023736
n3:aktivita
n14:I
n3:aktivity
I
n3:cisloPeriodika
35
n3:dodaniDat
n11:2014
n3:domaciTvurceVysledku
n4:3073572
n3:druhVysledku
n15:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
77225
n3:idVysledku
RIV/00023736:_____/13:00010741
n3:jazykVysledku
n10:eng
n3:klicovaSlova
hepcidin; iron metabolism; alpha-2-macroglobulin
n3:klicoveSlovo
n6:alpha-2-macroglobulin n6:hepcidin n6:iron%20metabolism
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[882F9DE87B42]
n3:nazevZdroje
Journal of biological chemistry
n3:obor
n19:CE
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
7
n3:rokUplatneniVysledku
n11:2013
n3:svazekPeriodika
288
n3:tvurceVysledku
Huang, M.L.H. Vyoral, Daniel Poňka, P. Austin, C.J.D. Sari, M.-A. Rahmanto, Y. S. Richardson, D.
n3:wos
000330619000041
s:issn
0021-9258
s:numberOfPages
16
n13:doi
10.1074/jbc.M113.471573