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Statements

Subject Item
n2:RIV%2F00023736%3A_____%2F13%3A00010715%21RIV14-MZ0-00023736
rdf:type
skos:Concept n10:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1182/blood-2013-03-487728
dcterms:description
We found that conventional Sanger sequencing had misclassified or underestimated BCR-ABL mutation status in 55% of the samples, where mutations with 1-15% abundance were detected. A complex clonal texture was uncovered by clonal analysis of samples harbouring multiple mutations and up to thirteen different mutated populations were identified. The landscape of these mutated populations was found to be highly dynamic. The high degree of complexity uncovered by UDS indicates that conventional Sanger sequencing might be an inadequate tool to assess BCR-ABL KD mutation status, that currently represents an important component of the therapeutic decision algorithms. Further evaluation of the clinical usefulness of UDS-based approaches is warranted. We found that conventional Sanger sequencing had misclassified or underestimated BCR-ABL mutation status in 55% of the samples, where mutations with 1-15% abundance were detected. A complex clonal texture was uncovered by clonal analysis of samples harbouring multiple mutations and up to thirteen different mutated populations were identified. The landscape of these mutated populations was found to be highly dynamic. The high degree of complexity uncovered by UDS indicates that conventional Sanger sequencing might be an inadequate tool to assess BCR-ABL KD mutation status, that currently represents an important component of the therapeutic decision algorithms. Further evaluation of the clinical usefulness of UDS-based approaches is warranted.
dcterms:title
Unraveling the complexity of tyrosine kinase inhibitor-resistant populations by ultra-deep sequencing of the BCR-ABL kinase domain Unraveling the complexity of tyrosine kinase inhibitor-resistant populations by ultra-deep sequencing of the BCR-ABL kinase domain
skos:prefLabel
Unraveling the complexity of tyrosine kinase inhibitor-resistant populations by ultra-deep sequencing of the BCR-ABL kinase domain Unraveling the complexity of tyrosine kinase inhibitor-resistant populations by ultra-deep sequencing of the BCR-ABL kinase domain
skos:notation
RIV/00023736:_____/13:00010715!RIV14-MZ0-00023736
n10:predkladatel
n20:ico%3A00023736
n3:aktivita
n19:P
n3:aktivity
P(NT11555)
n3:cisloPeriodika
9
n3:dodaniDat
n13:2014
n3:domaciTvurceVysledku
n7:8435553 n7:6663745 n7:7848226
n3:druhVysledku
n18:J
n3:duvernostUdaju
n6:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
112703
n3:idVysledku
RIV/00023736:_____/13:00010715
n3:jazykVysledku
n11:eng
n3:klicovaSlova
chronic myeloid leukemia; multiple myeloma; Imatinib; therapy; minority
n3:klicoveSlovo
n9:multiple%20myeloma n9:chronic%20myeloid%20leukemia n9:minority n9:therapy n9:Imatinib
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[14FE396B8F45]
n3:nazevZdroje
Blood
n3:obor
n12:FD
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
26
n3:projekt
n15:NT11555
n3:rokUplatneniVysledku
n13:2013
n3:svazekPeriodika
122
n3:tvurceVysledku
Roller, A. Giannini, B. Cavo, M. Castagnetti, F. Venturi, C. Soverini, S. Binotto, G. Broučková, Adéla Palandri, F. Kohlmann, A. Cattina, F. Papayannidis, C. Klamová, Hana Bresciani, P. Horner, D. Bochicchio, M. T. Martinelli, G. Rosti, G. Iacobucci, I. Gugliotta, G. De Benedittis, C. Russo, D. Machová Poláková, Kateřina Iacono, M. Haferlach, T. Baccarani, M.
n3:wos
000324056500018
s:issn
0006-4971
s:numberOfPages
14
n8:doi
10.1182/blood-2013-03-487728