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Statements

Subject Item
n2:RIV%2F00023736%3A_____%2F13%3A00009659%21RIV14-MZ0-00023736
rdf:type
n7:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org//10.1111/j.1600-0714.2012.01185.x
dcterms:description
Galectins are potent effectors of cell adhesion and growth regulation. Their expression as comples network necessitates systematic study of each member of this family. Toward this aim, we here focus on the tandem-repeat-type galectin-9. Its presence is monitored in normal squamous epithelium of the head and neck, the surgical margin, and four types of squamous cell carcinoma. Lectin presence was detected in cells of the basal layer of the epithelium. All galectin-9-negative epithelia showed aberrant positivity for keratins 14 and 19. The surgical margin presented either a normal pattern of galectin-9 and keratin presence or a mosaic-like presence/absence of galectin-9 and aberrant expression of both keratins 14 and 19. All studied specimens of squamous cell carcinoma were negative for galectin-9. When biotinylated galectin-9, or its N-terminal domain, was tested, no significant tissue reactivity for both probes was observed. Neuraminidase treatment generated reactivity to the N-domain. Galectins are potent effectors of cell adhesion and growth regulation. Their expression as comples network necessitates systematic study of each member of this family. Toward this aim, we here focus on the tandem-repeat-type galectin-9. Its presence is monitored in normal squamous epithelium of the head and neck, the surgical margin, and four types of squamous cell carcinoma. Lectin presence was detected in cells of the basal layer of the epithelium. All galectin-9-negative epithelia showed aberrant positivity for keratins 14 and 19. The surgical margin presented either a normal pattern of galectin-9 and keratin presence or a mosaic-like presence/absence of galectin-9 and aberrant expression of both keratins 14 and 19. All studied specimens of squamous cell carcinoma were negative for galectin-9. When biotinylated galectin-9, or its N-terminal domain, was tested, no significant tissue reactivity for both probes was observed. Neuraminidase treatment generated reactivity to the N-domain.
dcterms:title
Loss of adhesion/growth-regulatory galectin-9 from squamous cell epithelium in head and neck carcinomas Loss of adhesion/growth-regulatory galectin-9 from squamous cell epithelium in head and neck carcinomas
skos:prefLabel
Loss of adhesion/growth-regulatory galectin-9 from squamous cell epithelium in head and neck carcinomas Loss of adhesion/growth-regulatory galectin-9 from squamous cell epithelium in head and neck carcinomas
skos:notation
RIV/00023736:_____/13:00009659!RIV14-MZ0-00023736
n7:predkladatel
n8:ico%3A00023736
n4:aktivita
n11:V n11:S n11:I
n4:aktivity
I, S, V
n4:cisloPeriodika
2
n4:dodaniDat
n15:2014
n4:domaciTvurceVysledku
n9:7578180 n9:1295217
n4:druhVysledku
n14:J
n4:duvernostUdaju
n13:S
n4:entitaPredkladatele
n10:predkladatel
n4:idSjednocenehoVysledku
85442
n4:idVysledku
RIV/00023736:_____/13:00009659
n4:jazykVysledku
n17:eng
n4:klicovaSlova
agglutinin; basal cells; epithelium; keratin; lectin; tumor
n4:klicoveSlovo
n12:agglutinin n12:tumor n12:keratin n12:epithelium n12:lectin n12:basal%20cells
n4:kodStatuVydavatele
DK - Dánské království
n4:kontrolniKodProRIV
[D583C128E6AB]
n4:nazevZdroje
Journal of oral pathology & medicine
n4:obor
n18:FD
n4:pocetDomacichTvurcuVysledku
2
n4:pocetTvurcuVysledku
12
n4:rokUplatneniVysledku
n15:2013
n4:svazekPeriodika
42
n4:tvurceVysledku
Kodet, R. André, S. Tachezy, Ruth Kaltner, H. Fík, Z. Foltynová, Eva Chovanec, M. Gabius, H. J. Kodet, O. Valach, J. Smetana, K. Mazánek, J.
n4:wos
000314471200008
s:issn
0904-2512
s:numberOfPages
8
n16:doi
10.1111/j.1600-0714.2012.01185.x