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Statements

Subject Item
n2:RIV%2F00023736%3A_____%2F12%3A00010472%21RIV13-MZ0-00023736
rdf:type
skos:Concept n15:Vysledek
rdfs:seeAlso
http://www.zsf.jcu.cz/jab/10_2/smetana.html
dcterms:description
As it is generally known, the heterochromatin is an useful marker of the cell maturity including its pathology. The goal of the study was to provide more information on the heterochromatin DNA state in chromosomes and central gene rich nuclear regions of single proliferating progenitors of human leukemic granulocytes. The computer image densitometry at the single cell level indicated that heterochromatin fibrils of similar width in the central nuclear regions are characterized by a similar DNA heterochromatin condensation state. Thus the DNA segments in heterochromatin fibrils represent masked chromosomal segments, which possibly carry silent genes. This observation is in harmony with the „classical cytology“ according to which such chromatin regions correspond to the chromosomal territories. As it is generally known, the heterochromatin is an useful marker of the cell maturity including its pathology. The goal of the study was to provide more information on the heterochromatin DNA state in chromosomes and central gene rich nuclear regions of single proliferating progenitors of human leukemic granulocytes. The computer image densitometry at the single cell level indicated that heterochromatin fibrils of similar width in the central nuclear regions are characterized by a similar DNA heterochromatin condensation state. Thus the DNA segments in heterochromatin fibrils represent masked chromosomal segments, which possibly carry silent genes. This observation is in harmony with the „classical cytology“ according to which such chromatin regions correspond to the chromosomal territories.
dcterms:title
The DNA chromatin condensation expressed by the image optical density of chromosomes and chromatin in proliferating single human leukemic granulocytic progenitors The DNA chromatin condensation expressed by the image optical density of chromosomes and chromatin in proliferating single human leukemic granulocytic progenitors
skos:prefLabel
The DNA chromatin condensation expressed by the image optical density of chromosomes and chromatin in proliferating single human leukemic granulocytic progenitors The DNA chromatin condensation expressed by the image optical density of chromosomes and chromatin in proliferating single human leukemic granulocytic progenitors
skos:notation
RIV/00023736:_____/12:00010472!RIV13-MZ0-00023736
n15:predkladatel
n17:ico%3A00023736
n6:aktivita
n13:Z
n6:aktivity
Z(MZ0UHKT2005)
n6:cisloPeriodika
2
n6:dodaniDat
n19:2013
n6:domaciTvurceVysledku
n12:7598378 n12:7848226 n12:7160046 n12:6264786 n12:1709615
n6:druhVysledku
n9:J
n6:duvernostUdaju
n16:S
n6:entitaPredkladatele
n20:predkladatel
n6:idSjednocenehoVysledku
131754
n6:idVysledku
RIV/00023736:_____/12:00010472
n6:jazykVysledku
n7:eng
n6:klicovaSlova
heterochromatin image optical density; chromosomes; central and peripheral nuclear regions; proliferating cells-human leukemic myeloblasts
n6:klicoveSlovo
n8:proliferating%20cells-human%20leukemic%20myeloblasts n8:central%20and%20peripheral%20nuclear%20regions n8:heterochromatin%20image%20optical%20density n8:chromosomes
n6:kodStatuVydavatele
CZ - Česká republika
n6:kontrolniKodProRIV
[418466E6B1C9]
n6:nazevZdroje
Journal of applied biomedicine
n6:obor
n18:FD
n6:pocetDomacichTvurcuVysledku
5
n6:pocetTvurcuVysledku
6
n6:rokUplatneniVysledku
n19:2012
n6:svazekPeriodika
10
n6:tvurceVysledku
Klamová, Hana Mikulenková, Dana Zápotocký, M. Hrkal, Zbyněk Jirásková, Ilona Smetana, Karel
n6:wos
000300929300005
n6:zamer
n11:MZ0UHKT2005
s:issn
1214-021X
s:numberOfPages
6
n3:doi
10.2478/v10136-011-0005-4