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Statements

Subject Item
n2:RIV%2F00023736%3A_____%2F12%3A00010460%21RIV13-MZ0-00023736
rdf:type
skos:Concept n17:Vysledek
rdfs:seeAlso
http://www.hindawi.com/journals/lrt/2012/179402/
dcterms:description
Myelodysplastic syndrome (MDS) with interstitial deletion of a segment of the long arm of chromosome 5q [del(5q)] is characterized by bone marrow erythroid hyperplasia, atypical megakaryocytes, thrombocythemia, refractory anemia, and low risk of progression to acute myeloid leukemia (AML) compared with other types of MDS. The long arm of chromosome 5 contains two distinct commonly deleted regions (CDRs). The more distal CDR lies in 5q33.1 and contains 40 protein coding genes and genes coding microRNAs (miR-143, miR-145). In 5q- syndrome one allele is deleted that accounts for haploinsufficiency of these genes Myelodysplastic syndrome (MDS) with interstitial deletion of a segment of the long arm of chromosome 5q [del(5q)] is characterized by bone marrow erythroid hyperplasia, atypical megakaryocytes, thrombocythemia, refractory anemia, and low risk of progression to acute myeloid leukemia (AML) compared with other types of MDS. The long arm of chromosome 5 contains two distinct commonly deleted regions (CDRs). The more distal CDR lies in 5q33.1 and contains 40 protein coding genes and genes coding microRNAs (miR-143, miR-145). In 5q- syndrome one allele is deleted that accounts for haploinsufficiency of these genes
dcterms:title
Important genes in the pathogenesis of 5q- syndrome and their connection with ribosomal stress and innate immune system pathway Important genes in the pathogenesis of 5q- syndrome and their connection with ribosomal stress and innate immune system pathway
skos:prefLabel
Important genes in the pathogenesis of 5q- syndrome and their connection with ribosomal stress and innate immune system pathway Important genes in the pathogenesis of 5q- syndrome and their connection with ribosomal stress and innate immune system pathway
skos:notation
RIV/00023736:_____/12:00010460!RIV13-MZ0-00023736
n17:predkladatel
n18:ico%3A00023736
n3:aktivita
n14:P n14:Z
n3:aktivity
P(LC06044), Z(MZ0UHKT2005)
n3:cisloPeriodika
179402
n3:dodaniDat
n20:2013
n3:domaciTvurceVysledku
n8:7991401
n3:druhVysledku
n11:J
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
140899
n3:idVysledku
RIV/00023736:_____/12:00010460
n3:jazykVysledku
n6:eng
n3:klicovaSlova
myelodysplastic syndrome; 5q- syndrome; ribosomal stress; ribosomopathies; microRNAs; p53; lenalidomide
n3:klicoveSlovo
n4:lenalidomide n4:ribosomal%20stress n4:ribosomopathies n4:microRNAs n4:5q-%20syndrome n4:p53 n4:myelodysplastic%20syndrome
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[EA1FFE84EC0D]
n3:nazevZdroje
Leukemia research and treatment
n3:obor
n16:FD
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
1
n3:projekt
n21:LC06044
n3:rokUplatneniVysledku
n20:2012
n3:tvurceVysledku
Fuchs, Ota
n3:zamer
n9:MZ0UHKT2005
s:issn
2090-3227
s:numberOfPages
14
n12:doi
10.1155/2012/179402