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Statements

Subject Item
n2:RIV%2F00023736%3A_____%2F11%3A00009325%21RIV12-MZ0-00023736
rdf:type
n11:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.2174/157436211794109398
dcterms:description
Transforming growth factor-beta is a cytokine involved in cell proliferation, apoptosis, differentiation, angiogenesis, cell adhesion, migration, extracellular matrix deposition, wound healing and immune response. TGF-beta supresses tumor growth in early phase of neoplasia, while promotes tumor progression and metastasis in later phases.Therefore, several possibilities for the disruption of TGF-beta signaling is very important in the treatment of tumor metastasis and fibrotic diseases. Transforming growth factor-beta is a cytokine involved in cell proliferation, apoptosis, differentiation, angiogenesis, cell adhesion, migration, extracellular matrix deposition, wound healing and immune response. TGF-beta supresses tumor growth in early phase of neoplasia, while promotes tumor progression and metastasis in later phases.Therefore, several possibilities for the disruption of TGF-beta signaling is very important in the treatment of tumor metastasis and fibrotic diseases.
dcterms:title
Inhibition of TGF-beta signaling for the treatment of tumor metastasis and fibrotic diseases Inhibition of TGF-beta signaling for the treatment of tumor metastasis and fibrotic diseases
skos:prefLabel
Inhibition of TGF-beta signaling for the treatment of tumor metastasis and fibrotic diseases Inhibition of TGF-beta signaling for the treatment of tumor metastasis and fibrotic diseases
skos:notation
RIV/00023736:_____/11:00009325!RIV12-MZ0-00023736
n11:predkladatel
n17:ico%3A00023736
n3:aktivita
n9:Z n9:P
n3:aktivity
P(LC06044), Z(MZ0UHKT2005)
n3:cisloPeriodika
1
n3:dodaniDat
n10:2012
n3:domaciTvurceVysledku
n18:7991401
n3:druhVysledku
n20:J
n3:duvernostUdaju
n21:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
204848
n3:idVysledku
RIV/00023736:_____/11:00009325
n3:jazykVysledku
n12:eng
n3:klicovaSlova
Inhibitory Smad; receptor-regulated Smads; small interfering RNA; TGF-beta monoclonal antibody; TGF-beta receptor kinase I inhibitors; TGF-beta signaling; transforming growth factor-beta
n3:klicoveSlovo
n6:small%20interfering%20RNA n6:Inhibitory%20Smad n6:receptor-regulated%20Smads n6:transforming%20growth%20factor-beta n6:TGF-beta%20monoclonal%20antibody n6:TGF-beta%20receptor%20kinase%20I%20inhibitors n6:TGF-beta%20signaling
n3:kodStatuVydavatele
AE - Stát Spojené arabské emiráty
n3:kontrolniKodProRIV
[A6529DF00308]
n3:nazevZdroje
Current Signal Transduction Therapy
n3:obor
n15:FD
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
1
n3:projekt
n19:LC06044
n3:rokUplatneniVysledku
n10:2011
n3:svazekPeriodika
6
n3:tvurceVysledku
Fuchs, Ota
n3:zamer
n4:MZ0UHKT2005
s:issn
1574-3624
s:numberOfPages
6
n14:doi
10.2174/157436211794109398