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Statements

Subject Item
n2:RIV%2F00023736%3A_____%2F11%3A00009282%21RIV12-MZ0-00023736
rdf:type
n14:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org./10.1002/ajh.22100
dcterms:description
To determine the major presenting features of the most frequent leukemias and to describe the period from the first symptoms to the final diagnosis, we analyzed the records of 1,004 consecutive patients with acute (AL) and chronic (CL) leukemias diagnosed between 2004 and 2009. In 24% of AL and 63% of CL, the diagnosis was made incidentally. In contrast to the frequency of the symptoms, their spectrum did not differ from historical studies, and fatigue and weakness were the most frequent symptoms observed [with the exception of acute promyelocytic leukemia (APL) where bleeding predominated]. More profound cytopenia was found in AL compared to CL. The median time from the first symptoms to final diagnosis was 3 weeks in AL and 4 weeks in CL. APL had the shortest time to a definitive diagnosis (2 weeks); however, a very short duration of symptoms was also observed in CML (3 weeks). This study is the largest series reported to date on symptoms in leukemia patients at the time of diagnosis To determine the major presenting features of the most frequent leukemias and to describe the period from the first symptoms to the final diagnosis, we analyzed the records of 1,004 consecutive patients with acute (AL) and chronic (CL) leukemias diagnosed between 2004 and 2009. In 24% of AL and 63% of CL, the diagnosis was made incidentally. In contrast to the frequency of the symptoms, their spectrum did not differ from historical studies, and fatigue and weakness were the most frequent symptoms observed [with the exception of acute promyelocytic leukemia (APL) where bleeding predominated]. More profound cytopenia was found in AL compared to CL. The median time from the first symptoms to final diagnosis was 3 weeks in AL and 4 weeks in CL. APL had the shortest time to a definitive diagnosis (2 weeks); however, a very short duration of symptoms was also observed in CML (3 weeks). This study is the largest series reported to date on symptoms in leukemia patients at the time of diagnosis
dcterms:title
Clinical and laboratory features of leukemias at the time of diagnosis: an analysis of 1,004 consecutive patients. Clinical and laboratory features of leukemias at the time of diagnosis: an analysis of 1,004 consecutive patients.
skos:prefLabel
Clinical and laboratory features of leukemias at the time of diagnosis: an analysis of 1,004 consecutive patients. Clinical and laboratory features of leukemias at the time of diagnosis: an analysis of 1,004 consecutive patients.
skos:notation
RIV/00023736:_____/11:00009282!RIV12-MZ0-00023736
n14:predkladatel
n16:ico%3A00023736
n3:aktivita
n11:V n11:Z
n3:aktivity
V, Z(MSM0021622430)
n3:cisloPeriodika
9
n3:dodaniDat
n5:2012
n3:domaciTvurceVysledku
n15:1459368
n3:druhVysledku
n19:J
n3:duvernostUdaju
n13:S
n3:entitaPredkladatele
n7:predkladatel
n3:idSjednocenehoVysledku
190607
n3:idVysledku
RIV/00023736:_____/11:00009282
n3:jazykVysledku
n18:eng
n3:klicovaSlova
clinical laboratory features; leukemia diagnosis; leukemia
n3:klicoveSlovo
n12:clinical%20laboratory%20features n12:leukemia n12:leukemia%20diagnosis
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[EBDD11A4B263]
n3:nazevZdroje
American Journal of Hematology
n3:obor
n8:FD
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
10
n3:rokUplatneniVysledku
n5:2011
n3:svazekPeriodika
86
n3:tvurceVysledku
Rázga, F. Brejcha, M. Burešová, L. Zounar, R. Mayer, J. Procházková, J. Cetkovský, Petr Timilsina, S. Tošková, M. Ráčil, Z.
n3:wos
000295003800019
n3:zamer
n9:MSM0021622430
s:issn
0361-8609
s:numberOfPages
4
n20:doi
10.1002/ajh.22100