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Statements

Subject Item
n2:RIV%2F00023736%3A_____%2F11%3A00009273%21RIV12-MZ0-00023736
rdf:type
skos:Concept n14:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1111/j.1600-0609.2011.01639.x
dcterms:description
The impact of modern prognostic markers on clinical course of chronic lymphocytic leukemia (CLL) in everyday practice has been not yet well-defined, especially in large series of patients. Therefore, the goal of the present study was to assess the influence of conventional as well as modern prognostic factors on overall survival (OS) and time to therapy (TTT) of CLL patients. Methods: We retrospectively analyzed data of all patients consecutively entered into the databases of five large academic centers in the Czech Republic. The total of 1300 patients was included in the analysis. Results and conclusion: Through the use of uniparametric analysis, it was determined that gender, clinical stage Rai II-IV, unmutated IgVH status, 17p deletion (for both 5% and 20% cut-off), 11q deletion, ZAP-70 positivity and high expression of CD38 had significant negative influence on OS. TTT was significantly influenced by gender, Rai stage, IgVH status, 11q deletion, 17p deletion, 13q deletion and by CD The impact of modern prognostic markers on clinical course of chronic lymphocytic leukemia (CLL) in everyday practice has been not yet well-defined, especially in large series of patients. Therefore, the goal of the present study was to assess the influence of conventional as well as modern prognostic factors on overall survival (OS) and time to therapy (TTT) of CLL patients. Methods: We retrospectively analyzed data of all patients consecutively entered into the databases of five large academic centers in the Czech Republic. The total of 1300 patients was included in the analysis. Results and conclusion: Through the use of uniparametric analysis, it was determined that gender, clinical stage Rai II-IV, unmutated IgVH status, 17p deletion (for both 5% and 20% cut-off), 11q deletion, ZAP-70 positivity and high expression of CD38 had significant negative influence on OS. TTT was significantly influenced by gender, Rai stage, IgVH status, 11q deletion, 17p deletion, 13q deletion and by CD
dcterms:title
Modern and conventional prognostic markers of chronic lymphocytic leukaemia in the everyday haematological practice Modern and conventional prognostic markers of chronic lymphocytic leukaemia in the everyday haematological practice
skos:prefLabel
Modern and conventional prognostic markers of chronic lymphocytic leukaemia in the everyday haematological practice Modern and conventional prognostic markers of chronic lymphocytic leukaemia in the everyday haematological practice
skos:notation
RIV/00023736:_____/11:00009273!RIV12-MZ0-00023736
n14:predkladatel
n15:ico%3A00023736
n3:aktivita
n4:V n4:Z n4:P n4:I
n3:aktivity
I, P(NS10439), P(NS9858), P(NT11217), P(NT11218), V, Z(MSM0021620808), Z(MZ0FNHK2005)
n3:cisloPeriodika
2
n3:dodaniDat
n11:2012
n3:domaciTvurceVysledku
n10:7163045 n10:9564918
n3:druhVysledku
n20:J
n3:duvernostUdaju
n5:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
213256
n3:idVysledku
RIV/00023736:_____/11:00009273
n3:jazykVysledku
n17:eng
n3:klicovaSlova
chronic lymphocytic leukemia; cytogenetics; IgVh mutation status; prognostic markers; survival
n3:klicoveSlovo
n7:chronic%20lymphocytic%20leukemia n7:IgVh%20mutation%20status n7:survival n7:prognostic%20markers n7:cytogenetics
n3:kodStatuVydavatele
DK - Dánské království
n3:kontrolniKodProRIV
[0CEA894AA591]
n3:nazevZdroje
European Journal of Haematology
n3:obor
n19:FD
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
12
n3:projekt
n21:NS9858 n21:NS10439 n21:NT11217 n21:NT11218
n3:rokUplatneniVysledku
n11:2011
n3:svazekPeriodika
87
n3:tvurceVysledku
Smolej, L. Trněný, Marek Pospíšilová, Š. Obrtlíková, P. Brychtová, Y. Kozmon, P. Doubek, M. Mayer, J. Schwarz, Jiří Cmunt, E. Brejcha, M. Pospíšil, Z.
n3:wos
000292778800005
n3:zamer
n8:MZ0FNHK2005 n8:MSM0021620808
s:issn
0902-4441
s:numberOfPages
8
n13:doi
10.1111/j.1600-0609.2011.01639.x