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Statements

Subject Item
n2:RIV%2F00023736%3A_____%2F11%3A00009171%21RIV12-MZ0-00023736
rdf:type
skos:Concept n17:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.2174/157436211794109460
dcterms:description
The mammalian target of rapamycin (mTOR) is a downstream mediator of the phosphatidylinositol 3-kinase (PI3K)/Akt (protein kinase B) signaling pathway which regulates cell survival and proliferation. mTOR is a highly conserved serine/treonine kinase involved in the control of cell growth, protein synthesis, and cell cycle progression. Inhibitor of mTOR pathway have antiproliferative properties in hematological malignancies and are studied in therapeutic trials The mammalian target of rapamycin (mTOR) is a downstream mediator of the phosphatidylinositol 3-kinase (PI3K)/Akt (protein kinase B) signaling pathway which regulates cell survival and proliferation. mTOR is a highly conserved serine/treonine kinase involved in the control of cell growth, protein synthesis, and cell cycle progression. Inhibitor of mTOR pathway have antiproliferative properties in hematological malignancies and are studied in therapeutic trials
dcterms:title
Promising activity of mammalian target of rapamycin inhibitors in hematologic malignancies therapy Promising activity of mammalian target of rapamycin inhibitors in hematologic malignancies therapy
skos:prefLabel
Promising activity of mammalian target of rapamycin inhibitors in hematologic malignancies therapy Promising activity of mammalian target of rapamycin inhibitors in hematologic malignancies therapy
skos:notation
RIV/00023736:_____/11:00009171!RIV12-MZ0-00023736
n17:predkladatel
n18:ico%3A00023736
n3:aktivita
n4:P n4:Z
n3:aktivity
P(LC06044), Z(MZ0UHKT2005)
n3:cisloPeriodika
1
n3:dodaniDat
n12:2012
n3:domaciTvurceVysledku
n13:7991401
n3:druhVysledku
n7:J
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
224625
n3:idVysledku
RIV/00023736:_____/11:00009171
n3:jazykVysledku
n10:eng
n3:klicovaSlova
hematological malignancies; Mammalian target of rapamycin; Phosphatase and tensin homologue tumor suppressor; Phosphatidylinositol 3-kinase; Protein kinase B; TOR inhibitors
n3:klicoveSlovo
n6:Mammalian%20target%20of%20rapamycin n6:hematological%20malignancies n6:Protein%20kinase%20B n6:TOR%20inhibitors n6:Phosphatase%20and%20tensin%20homologue%20tumor%20suppressor n6:Phosphatidylinositol%203-kinase
n3:kodStatuVydavatele
AE - Stát Spojené arabské emiráty
n3:kontrolniKodProRIV
[9C1791562316]
n3:nazevZdroje
Current Signal Transduction Therapy
n3:obor
n20:FD
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
1
n3:projekt
n15:LC06044
n3:rokUplatneniVysledku
n12:2011
n3:svazekPeriodika
6
n3:tvurceVysledku
Fuchs, Ota
n3:zamer
n9:MZ0UHKT2005
s:issn
1574-3624
s:numberOfPages
11
n21:doi
10.2174/157436211794109460