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Statements

Subject Item
n2:RIV%2F00023736%3A_____%2F11%3A00009168%21RIV12-MZ0-00023736
rdf:type
skos:Concept n11:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1186/1756-8722-4-1
dcterms:description
MicroRNAs (miRNAs) are important regulators of hematopoiesis and their aberrant expression was detected in some clonal hematopoietic disorders. We thus analyzed miRNA expressions in bone marrow CD34+ cells of 5q- syndrome patients. within the 5q deletion. Using microarrays we identified 21 differently expressed miRNAs in 5q- patients compared to controls. Especially, miR-34a was markedly overexpressed in 5q- patients, suggesting its role in an increased apoptosis of bone marrow progenitors MicroRNAs (miRNAs) are important regulators of hematopoiesis and their aberrant expression was detected in some clonal hematopoietic disorders. We thus analyzed miRNA expressions in bone marrow CD34+ cells of 5q- syndrome patients. within the 5q deletion. Using microarrays we identified 21 differently expressed miRNAs in 5q- patients compared to controls. Especially, miR-34a was markedly overexpressed in 5q- patients, suggesting its role in an increased apoptosis of bone marrow progenitors
dcterms:title
Differential expression of microRNAs in CD34+ cells of 5q- syndrome Differential expression of microRNAs in CD34+ cells of 5q- syndrome
skos:prefLabel
Differential expression of microRNAs in CD34+ cells of 5q- syndrome Differential expression of microRNAs in CD34+ cells of 5q- syndrome
skos:notation
RIV/00023736:_____/11:00009168!RIV12-MZ0-00023736
n11:predkladatel
n16:ico%3A00023736
n3:aktivita
n12:P n12:V n12:Z
n3:aktivity
P(GP301/09/P579), V, Z(MZ0UHKT2005)
n3:cisloPeriodika
1
n3:dodaniDat
n4:2012
n3:domaciTvurceVysledku
n8:9130969 n8:4787552 n8:8293406 n8:6244580 n8:7870701
n3:druhVysledku
n6:J
n3:duvernostUdaju
n20:S
n3:entitaPredkladatele
n19:predkladatel
n3:idSjednocenehoVysledku
194589
n3:idVysledku
RIV/00023736:_____/11:00009168
n3:jazykVysledku
n14:eng
n3:klicovaSlova
microRNA; CD34+ cells; 5q- syndrome
n3:klicoveSlovo
n10:5q-%20syndrome n10:CD34%2B%20cells n10:microRNA
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[CE220A5D9771]
n3:nazevZdroje
Journal of Hematology & Oncology
n3:obor
n21:FD
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
7
n3:projekt
n15:GP301%2F09%2FP579
n3:rokUplatneniVysledku
n4:2011
n3:svazekPeriodika
4
n3:tvurceVysledku
Beličková, Monika Neuwirtová, R. Votavová, Hana Grmanová, M. Dostálová Merkerová, Michaela Vašíková, Alžběta Čermák, Jaroslav
n3:wos
000286527700001
n3:zamer
n17:MZ0UHKT2005
s:issn
1756-8722
s:numberOfPages
6
n7:doi
10.1186/1756-8722-4-1