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Statements

Subject Item
n2:RIV%2F00023736%3A_____%2F10%3A00008723%21RIV11-MZ0-00023736
rdf:type
n9:Vysledek skos:Concept
dcterms:description
Hypermethylation of CpG islands within gene promoters is one of various mechanisms of gene silencing involved in the pathogenesis of human cancer. By using methylation-specific polymerase chain reaction we explored aberrant promoter methylation of five tumour suppressor genes in 29 patients with chronic lymphocytic leukaemia. Aberrant methylation of DLC1, SHP1, p15 and p16 occurred, respectively, in 89.7 %, 70 %, 62.1 % and 31 % of patients at diagnosis. Lamin A/C was unmethylated in all the samples. Hypermethylation of at least one gene was detected in 96.6 % of patients. Concurrent methylation of two or more genes correlated with Rai stage at diagnosis. Hypermethylation of CpG islands within gene promoters is one of various mechanisms of gene silencing involved in the pathogenesis of human cancer. By using methylation-specific polymerase chain reaction we explored aberrant promoter methylation of five tumour suppressor genes in 29 patients with chronic lymphocytic leukaemia. Aberrant methylation of DLC1, SHP1, p15 and p16 occurred, respectively, in 89.7 %, 70 %, 62.1 % and 31 % of patients at diagnosis. Lamin A/C was unmethylated in all the samples. Hypermethylation of at least one gene was detected in 96.6 % of patients. Concurrent methylation of two or more genes correlated with Rai stage at diagnosis.
dcterms:title
Advanced Rai stage in patients with chronic lymphotic leukaemia correlates with simultaneous hypermethylation of plural tumour suppressor genes Advanced Rai stage in patients with chronic lymphotic leukaemia correlates with simultaneous hypermethylation of plural tumour suppressor genes
skos:prefLabel
Advanced Rai stage in patients with chronic lymphotic leukaemia correlates with simultaneous hypermethylation of plural tumour suppressor genes Advanced Rai stage in patients with chronic lymphotic leukaemia correlates with simultaneous hypermethylation of plural tumour suppressor genes
skos:notation
RIV/00023736:_____/10:00008723!RIV11-MZ0-00023736
n3:aktivita
n14:I n14:V n14:Z
n3:aktivity
I, V, Z(MSM0021620808)
n3:cisloPeriodika
4
n3:dodaniDat
n11:2011
n3:domaciTvurceVysledku
n15:9564918
n3:druhVysledku
n13:J
n3:duvernostUdaju
n4:S
n3:entitaPredkladatele
n5:predkladatel
n3:idSjednocenehoVysledku
245521
n3:idVysledku
RIV/00023736:_____/10:00008723
n3:jazykVysledku
n10:eng
n3:klicovaSlova
chronic lymphotic leukaemia; aberrant hypermethylation; tumour-suppressor gene; Rai stage; methylation-specific polymerase chain reaction
n3:klicoveSlovo
n6:methylation-specific%20polymerase%20chain%20reaction n6:aberrant%20hypermethylation n6:chronic%20lymphotic%20leukaemia n6:tumour-suppressor%20gene n6:Rai%20stage
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[5BD5E81F0E71]
n3:nazevZdroje
Folia Biologica
n3:obor
n16:FD
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
6
n3:rokUplatneniVysledku
n11:2010
n3:svazekPeriodika
56
n3:tvurceVysledku
Štuka, Č. Schwarz, Jiří Forsterová, K. Trněný, M. Votavová, H. Karban, J.
n3:wos
000281924500003
n3:zamer
n17:MSM0021620808
s:issn
0015-5500
s:numberOfPages
7