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Statements

Subject Item
n2:RIV%2F00023736%3A_____%2F10%3A00008343%21RIV11-MZ0-00023736
rdf:type
n8:Vysledek skos:Concept
dcterms:description
Genetic instability associated with telomere dysfunction (i.e. short telomeres) is an early event in carcinogenesis. The molecular cytogenetic method telomere/centromere fluorescence in situ hybridization (T/C-FISH) can be used to characterize the telomere length of hematopoietic cells. This review describes recent advances in the molecular characterization of telomere system, the regulation of telomerase activity in cancer pathogenesis and shows that the telomeric length could be a potential clinical marker of hematologic neoplasia and prognosis of disease. Genetic instability associated with telomere dysfunction (i.e. short telomeres) is an early event in carcinogenesis. The molecular cytogenetic method telomere/centromere fluorescence in situ hybridization (T/C-FISH) can be used to characterize the telomere length of hematopoietic cells. This review describes recent advances in the molecular characterization of telomere system, the regulation of telomerase activity in cancer pathogenesis and shows that the telomeric length could be a potential clinical marker of hematologic neoplasia and prognosis of disease.
dcterms:title
The role of telomeres and telomerase complex in haematological neoplasia : the length of telomeres as a marker of carcinogenesis and prognosis of disease The role of telomeres and telomerase complex in haematological neoplasia : the length of telomeres as a marker of carcinogenesis and prognosis of disease
skos:prefLabel
The role of telomeres and telomerase complex in haematological neoplasia : the length of telomeres as a marker of carcinogenesis and prognosis of disease The role of telomeres and telomerase complex in haematological neoplasia : the length of telomeres as a marker of carcinogenesis and prognosis of disease
skos:notation
RIV/00023736:_____/10:00008343!RIV11-MZ0-00023736
n3:aktivita
n10:V n10:Z n10:P
n3:aktivity
P(LC535), V, Z(MSM0021620808), Z(MZ0VFN2005)
n3:cisloPeriodika
2
n3:dodaniDat
n9:2011
n3:domaciTvurceVysledku
n14:3340961 n14:6881203
n3:druhVysledku
n13:J
n3:duvernostUdaju
n11:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
285756
n3:idVysledku
RIV/00023736:_____/10:00008343
n3:jazykVysledku
n18:eng
n3:klicovaSlova
telomere; telomerase; leukemia; senescence
n3:klicoveSlovo
n7:telomerase n7:telomere n7:senescence n7:leukemia
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[1116A2BBC85F]
n3:nazevZdroje
Prague Medical Report
n3:obor
n17:FD
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
6
n3:projekt
n4:LC535
n3:rokUplatneniVysledku
n9:2010
n3:svazekPeriodika
111
n3:tvurceVysledku
Gančarčíková, M. Šmigová, J. Včelíková, Soňa Michalová, K. Březinová, Jana Zemanová, Z.
n3:zamer
n15:MZ0VFN2005 n15:MSM0021620808
s:issn
1214-6994
s:numberOfPages
15