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Statements

Subject Item
n2:RIV%2F00023736%3A_____%2F09%3A00008279%21RIV10-MZ0-00023736
rdf:type
skos:Concept n14:Vysledek
dcterms:description
Proteasome inhibition is considered as novel treatment strategy in leukemia. We studied the effect of bortezomib (10 nM) on DNA synthesis and apoptosis in human acute myeloid cell lines KASUMI-1, ML-1, ML-2 and CTV-1 cells. Bortezomib was potent inhibitor of DNA synthesisin all four types of leukemia cells but not in ML-1 cells. Proteasome inhibition as monotherapy and its combination with histone deacetylase inhibitors and with conventional therapies is promising because malignant cells are more sensitive to this treatment than normal hematopoietic cells. Proteasome inhibition is considered as novel treatment strategy in leukemia. We studied the effect of bortezomib (10 nM) on DNA synthesis and apoptosis in human acute myeloid cell lines KASUMI-1, ML-1, ML-2 and CTV-1 cells. Bortezomib was potent inhibitor of DNA synthesisin all four types of leukemia cells but not in ML-1 cells. Proteasome inhibition as monotherapy and its combination with histone deacetylase inhibitors and with conventional therapies is promising because malignant cells are more sensitive to this treatment than normal hematopoietic cells.
dcterms:title
Antiproliferative and proapoptotic effects of proteasome inhibitors and their combination with histone deacetylase inhibitors on leukemia cells Antiproliferative and proapoptotic effects of proteasome inhibitors and their combination with histone deacetylase inhibitors on leukemia cells
skos:prefLabel
Antiproliferative and proapoptotic effects of proteasome inhibitors and their combination with histone deacetylase inhibitors on leukemia cells Antiproliferative and proapoptotic effects of proteasome inhibitors and their combination with histone deacetylase inhibitors on leukemia cells
skos:notation
RIV/00023736:_____/09:00008279!RIV10-MZ0-00023736
n3:aktivita
n8:V n8:Z n8:P
n3:aktivity
P(NR9045), V, Z(MZ0UHKT2005)
n3:cisloPeriodika
1
n3:dodaniDat
n4:2010
n3:domaciTvurceVysledku
n6:4073746 n6:7686323 n6:7991401 Marinov, Iuri
n3:druhVysledku
n16:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n5:predkladatel
n3:idSjednocenehoVysledku
303524
n3:idVysledku
RIV/00023736:_____/09:00008279
n3:jazykVysledku
n11:eng
n3:klicovaSlova
proteasome; proteasome inhibitors; histone deacetylase inhibitors; leukemia; apoptosis
n3:klicoveSlovo
n7:proteasome n7:apoptosis n7:proteasome%20inhibitors n7:leukemia n7:histone%20deacetylase%20inhibitors
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[FC70E99F927B]
n3:nazevZdroje
Cardiovascular & Hematological Disorders : Drug Targets
n3:obor
n17:FD
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
5
n3:projekt
n12:NR9045
n3:rokUplatneniVysledku
n4:2009
n3:svazekPeriodika
9
n3:tvurceVysledku
Špička, I. Fuchs, Ota Marinov, Iuri Provazníková, Dana Kuželová, Kateřina
n3:zamer
n13:MZ0UHKT2005
s:issn
1871-529X
s:numberOfPages
16