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Statements

Subject Item
n2:RIV%2F00023736%3A_____%2F08%3A00007135%21RIV08-MZ0-00023736
rdf:type
n7:Vysledek skos:Concept
dcterms:description
Four types of polymorphism and 25 mutations (3 already known mutations and 22 novel mutations) were detected in CEBPA gene in analysed samples from 390 patients. CEBPA mutations were found in 14/152 (9.2%) of acute myeloid leukemia (AML) patients samples, 6/143 (4.2%) of myelodysplastic syndrome (MDS) patients samples, 2/56 (3,6%) of non-Hodgkin’s lymphoma (NHL) patients samples and 2/39 (5.1%) of multiple myeloma (MM) patients samples. None CEBPA mutations were detected in healthy donors (41 individuals). We discuss how these mutations can affect the cellular function of C/EBPalpha and block the myeloid differentiation 4 typy polymorfizmu a 25 mutací (3 již známé mutace a 22 nových mutací) bylo detekováno v genu CEBPA v anylyzovaných vzorcích 390 pacientů. Mutace CEBPA byly nalezeny u 14/152 (9,2%) vzorků pacientů s akutní myeloidní leukémiií (AML), 6/143 (4,2%) vzorků pacientů s myelodysplastickým syndromem (MDS), 2/56 (3,6%) vzorků pacientů s neHodgkinským lymfomem (NHL) a 2/39 (5.1%) vzorků s mnohočetným myelomem (MM). Žádné mutace CEBPA nebyly detekovány u zdravých dárců (41 osob). Diskutujeme jak tyto mutace mohou ovlivnit buněčné funkce C/EBPalfa a blokovat myeloidní diferenciaci Four types of polymorphism and 25 mutations (3 already known mutations and 22 novel mutations) were detected in CEBPA gene in analysed samples from 390 patients. CEBPA mutations were found in 14/152 (9.2%) of acute myeloid leukemia (AML) patients samples, 6/143 (4.2%) of myelodysplastic syndrome (MDS) patients samples, 2/56 (3,6%) of non-Hodgkin’s lymphoma (NHL) patients samples and 2/39 (5.1%) of multiple myeloma (MM) patients samples. None CEBPA mutations were detected in healthy donors (41 individuals). We discuss how these mutations can affect the cellular function of C/EBPalpha and block the myeloid differentiation
dcterms:title
CEBPA polymorphisms and mutations in patients with acute myeloid leukemia, myelodysplastic syndrome, multiple myeloma and non-Hodgkin´s lymphoma CEBPA polymorphisms and mutations in patients with acute myeloid leukemia, myelodysplastic syndrome, multiple myeloma and non-Hodgkin´s lymphoma Polymorfizmus a mutace CEBPA u pacientů a akutní myeloidní leukémií, myelodysplastickým syndromem, mnohočetným myelomem a neHodgkinským lymfomem
skos:prefLabel
Polymorfizmus a mutace CEBPA u pacientů a akutní myeloidní leukémií, myelodysplastickým syndromem, mnohočetným myelomem a neHodgkinským lymfomem CEBPA polymorphisms and mutations in patients with acute myeloid leukemia, myelodysplastic syndrome, multiple myeloma and non-Hodgkin´s lymphoma CEBPA polymorphisms and mutations in patients with acute myeloid leukemia, myelodysplastic syndrome, multiple myeloma and non-Hodgkin´s lymphoma
skos:notation
RIV/00023736:_____/08:00007135!RIV08-MZ0-00023736
n3:strany
401;405
n3:aktivita
n9:P
n3:aktivity
P(NR9045)
n3:cisloPeriodika
3
n3:dodaniDat
n11:2008
n3:domaciTvurceVysledku
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n10:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
359002
n3:idVysledku
RIV/00023736:_____/08:00007135
n3:jazykVysledku
n15:eng
n3:klicovaSlova
acute myeloid leukemia; myelodysplastic syndrome; multiple myeloma; CEBPA mutations; non-Hodgkin ´s lymphoma
n3:klicoveSlovo
n4:CEBPA%20mutations n4:non-Hodgkin%20%C2%B4s%20lymphoma n4:myelodysplastic%20syndrome n4:multiple%20myeloma n4:acute%20myeloid%20leukemia
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[E39C9D7926F4]
n3:nazevZdroje
Blood Cells, Molecules and Diseases
n3:obor
n14:FD
n3:pocetDomacichTvurcuVysledku
11
n3:pocetTvurcuVysledku
17
n3:projekt
n16:NR9045
n3:rokUplatneniVysledku
n11:2008
n3:svazekPeriodika
40
n3:tvurceVysledku
Neuwirtová, R. Provazníková, Dana Fuchs, Ota Benešová, Kateřina Kostečka, Arnošt Marková, Jana Maaloufová, Jacqueline Lemež, P. Klamová, Hana Salaj, Peter Cveková, P. Březinová, Jana Kobylka, Petr Kočová, M. Čermák, Jaroslav Schwarz, Jiří Nováková, L.
s:issn
1079-9796
s:numberOfPages
5