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Statements

Subject Item
n2:RIV%2F00023736%3A_____%2F05%3A00006218%21RIV06-MZ0-00023736
rdf:type
skos:Concept n9:Vysledek
dcterms:description
The effects of Imatinib mesylate on CML cell lines K562 and JURL-MK1 were compared. Imatinib mesylate arrested both cell lines in G0/G1 phase and induced apoptosis that proceeded faster in JURL-MK1 and occurred in larger fraction of cell population. In addition, the erythroid differentiation was triggered in both cell lines. Byly porovnány účinky Imatinib mesylátu na CML buněčné linie K562 a JURL-MK1. U obou linií došlo k zastavení buněčného cyklu v G0/G1 fázi a byla indukována apoptoza jež u buněk JURL-MK1 probíhala rychleji a u větší části buněčné populace. Dále byla u obou linií navozena erytroidní diferenciace. The effects of Imatinib mesylate on CML cell lines K562 and JURL-MK1 were compared. Imatinib mesylate arrested both cell lines in G0/G1 phase and induced apoptosis that proceeded faster in JURL-MK1 and occurred in larger fraction of cell population. In addition, the erythroid differentiation was triggered in both cell lines.
dcterms:title
Rychlá apoptóza a erytroidní diferenciace indukovaná Imatinib mesylátem v buňkách K562. Fast apoptosis and erythroid differentiation induced by Imatinib mesylate in JURL-MK1 cells. Fast apoptosis and erythroid differentiation induced by Imatinib mesylate in JURL-MK1 cells.
skos:prefLabel
Fast apoptosis and erythroid differentiation induced by Imatinib mesylate in JURL-MK1 cells. Fast apoptosis and erythroid differentiation induced by Imatinib mesylate in JURL-MK1 cells. Rychlá apoptóza a erytroidní diferenciace indukovaná Imatinib mesylátem v buňkách K562.
skos:notation
RIV/00023736:_____/05:00006218!RIV06-MZ0-00023736
n3:strany
268;280
n3:aktivita
n13:P
n3:aktivity
P(NL7681)
n3:cisloPeriodika
2
n3:dodaniDat
n8:2006
n3:domaciTvurceVysledku
n5:4073746 n5:3682463 Marinov, Iuri n5:1709615
n3:druhVysledku
n14:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
521398
n3:idVysledku
RIV/00023736:_____/05:00006218
n3:jazykVysledku
n10:eng
n3:klicovaSlova
Imatinib mesylate; STI571; leukemia; apoptosis; erythroid differentiation
n3:klicoveSlovo
n4:Imatinib%20mesylate n4:erythroid%20differentiation n4:apoptosis n4:leukemia n4:STI571
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[7FB660092E41]
n3:nazevZdroje
Journal of Cellular Biochemistry
n3:obor
n12:FD
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:projekt
n15:NL7681
n3:rokUplatneniVysledku
n8:2005
n3:svazekPeriodika
95
n3:tvurceVysledku
Hrkal, Zbyněk Kuželová, Kateřina Marinov, Iuri Grebeňová, Dana
s:issn
0730-2312
s:numberOfPages
13