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Statements

Subject Item
n2:RIV%2F00023736%3A_____%2F04%3AI0000075%21RIV%2F2005%2FMZ0%2FL33005%2FN
rdf:type
skos:Concept n5:Vysledek
dcterms:description
Metodami biochemickými a metodami proteomové analýzy jsme zkoumali účinek inhibitoru histiondeacetyláz, butyrátu sodného (SB), na proliferaci a zrání buněčné linie K562 odvozené od CML. SB zastavuje buněčnou proliferaci a indukuje erytroidní diferenciaci buněk K562. Proteomovou analýzou byly odhaleny změny v expresi cyklofilinu A, SOD1, HSP90 a p23, jež odrážejí stresovou odpověď buněk na indukci SB. Using biochemical and proteome analysis methods we investigated the effects of sodium butyrate (SB) on the proliferation and maturation of CML-derived cell line K562. SB stops cell proliferation and induces erythroid differentiation of K562 cells. Proteome analysis revealed changes in cyclophilin A, SOD1, HSP90 and p23 expression that reflected stress response of cells to SB induction. Using biochemical and proteome analysis methods we investigated the effects of sodium butyrate (SB) on the proliferation and maturation of CML-derived cell line K562. SB stops cell proliferation and induces erythroid differentiation of K562 cells. Proteome analysis revealed changes in cyclophilin A, SOD1, HSP90 and p23 expression that reflected stress response of cells to SB induction.
dcterms:title
Proteome analysis of chronic myelogenous leukemia cells K562 subjected to butyrate treatment. Proteome analysis of chronic myelogenous leukemia cells K562 subjected to butyrate treatment. Proteomová analýza CML buněčných linií K562, vystavených účinku butyrátové terapie.
skos:prefLabel
Proteome analysis of chronic myelogenous leukemia cells K562 subjected to butyrate treatment. Proteomová analýza CML buněčných linií K562, vystavených účinku butyrátové terapie. Proteome analysis of chronic myelogenous leukemia cells K562 subjected to butyrate treatment.
skos:notation
RIV/00023736:_____/04:I0000075!RIV/2005/MZ0/L33005/N
n6:strany
204-205
n6:aktivita
n19:Z
n6:aktivity
Z(MZ00237360001)
n6:dodaniDat
n15:2005
n6:domaciTvurceVysledku
n10:8694249 n10:3682463 n10:1709615
n6:druhVysledku
n12:D
n6:duvernostUdaju
n18:S
n6:entitaPredkladatele
n14:predkladatel
n6:idSjednocenehoVysledku
582874
n6:idVysledku
RIV/00023736:_____/04:I0000075
n6:jazykVysledku
n8:eng
n6:klicovaSlova
sodium butyrate;K562;proteome analysis;CycA SOD1;HSP90;p23
n6:klicoveSlovo
n7:K562 n7:sodium%20butyrate n7:proteome%20analysis n7:p23 n7:HSP90 n7:CycA%20SOD1
n6:kontrolniKodProRIV
[F9B82ACE8369]
n6:mistoKonaniAkce
Bern
n6:mistoVydani
Bern
n6:nazevZdroje
Affolter, M., Gadola, S., Haeberli, A. a kol. (ed.). Proceedings of the Swiss proteomic society : 2004 congress proteomics for health
n6:obor
n9:FD
n6:pocetDomacichTvurcuVysledku
3
n6:pocetTvurcuVysledku
4
n6:rokUplatneniVysledku
n15:2004
n6:tvurceVysledku
Grebeňová, Dana Pešlová, Gabriela Halada, P. Hrkal, Zbyněk
n6:typAkce
n16:EUR
n6:zahajeniAkce
2004-12-06+01:00
n6:zamer
n11:MZ00237360001
s:numberOfPages
2
n13:hasPublisher
SPS