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Statements

Subject Item
n2:RIV%2F00023736%3A_____%2F04%3AI0000058%21RIV%2F2005%2FMZ0%2FL33005%2FN
rdf:type
skos:Concept n16:Vysledek
dcterms:description
By means of two-dimensional electrophoresis the effects of photodynamic therapy, ALA-PDT, were studied on leukemia cell lines HL60 and K562. By mass spectrometry (MALDI-TOF) the proteins affected by ALA-PDT were identified, among others the chaperones HSP60 and HSP90. ALA-PDT induced phosphorylation of HSP90 leading to the destabilization of the client (onco)protein BCR-ABL and its proteasomal degradation. Metodou dvojrozměrné elektroforézy byly studovány účinky fotodynamické terapie, ALA-PDT, na leukemické buněčné linie HL60 a K562. Hmotnostní spektrometrií (MALDI-TOF) byly identifikovány proteiny, jež byly ALA-PDT ovlivněny, kromě jiných chaperony HSP60 a HSP90. ALA-PDT indukovala v buňkách K562 fosforylaci HSP90 vedoucí k destabilizaci klientního (onko)proteinu BCR-ABL a jeho degradaci proteasomem. By means of two-dimensional electrophoresis the effects of photodynamic therapy, ALA-PDT, were studied on leukemia cell lines HL60 and K562. By mass spectrometry (MALDI-TOF) the proteins affected by ALA-PDT were identified, among others the chaperones HSP60 and HSP90. ALA-PDT induced phosphorylation of HSP90 leading to the destabilization of the client (onco)protein BCR-ABL and its proteasomal degradation.
dcterms:title
Leukemic cells treated with photodynamic therapy (ALA-PDT) exhibit different cell response in the expression and/or phosphorylation of some heat shock proteins. -činky fotodynamické terapie (ALA-PDT) a rozdílné reakce buněk v expresi a/nebo fosforylaci některých proteinů. Leukemic cells treated with photodynamic therapy (ALA-PDT) exhibit different cell response in the expression and/or phosphorylation of some heat shock proteins.
skos:prefLabel
Leukemic cells treated with photodynamic therapy (ALA-PDT) exhibit different cell response in the expression and/or phosphorylation of some heat shock proteins. Leukemic cells treated with photodynamic therapy (ALA-PDT) exhibit different cell response in the expression and/or phosphorylation of some heat shock proteins. -činky fotodynamické terapie (ALA-PDT) a rozdílné reakce buněk v expresi a/nebo fosforylaci některých proteinů.
skos:notation
RIV/00023736:_____/04:I0000058!RIV/2005/MZ0/L33005/N
n3:strany
183-184
n3:aktivita
n19:P
n3:aktivity
P(NL7681)
n3:dodaniDat
n17:2005
n3:domaciTvurceVysledku
n13:3682463 n13:1709615 n13:8375682
n3:druhVysledku
n10:D
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
571439
n3:idVysledku
RIV/00023736:_____/04:I0000058
n3:jazykVysledku
n7:eng
n3:klicovaSlova
HL60;K562;two-dimensional electrophoresis;photodynamic therapy;ALA-PDT;HSP90;BCR-ABL
n3:klicoveSlovo
n8:ALA-PDT n8:BCR-ABL n8:photodynamic%20therapy n8:two-dimensional%20electrophoresis n8:K562 n8:HSP90 n8:HL60
n3:kontrolniKodProRIV
[8081F8E4890F]
n3:mistoVydani
Olomouc
n3:nazevZdroje
Frébort, I., Walterová D. (ed.). Chemica 43S : supplement collected reports of the Natural science faculty, Palacký Univerzity Olomouc, Czech Republic
n3:obor
n6:FD
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
4
n3:projekt
n12:NL7681
n3:rokUplatneniVysledku
n17:2004
n3:tvurceVysledku
Pluskalová, Michaela Halada, P. Hrkal, Zbyněk Grebeňová, Dana
s:numberOfPages
2
n4:hasPublisher
Univerzita Palackého v Olomouci – Vydavatelství
n9:isbn
80-244-0882-1