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Statements

Subject Item
n2:RIV%2F00023736%3A_____%2F04%3AI0000035%21RIV%2F2005%2FMZ0%2FL33005%2FN
rdf:type
n13:Vysledek skos:Concept
dcterms:description
The effects of Imatinib mesylate on CML cell lines K562 and JURL-MK1 were compared. Imatinib mesylate arrested both cell lines in G0/G1 phase and induced apoptosis that proceeded faster in JURL-MK1 cells and occurred in larger fraction of cell population. In addition, the erythroid differentiation was triggered in both cell lines. Apoptosis and the erythroid differentiation are parallel effects of Imatinib mesylate and their relative contributions and kinetics are related to the differentiation stage of treated cells. The effects of Imatinib mesylate on CML cell lines K562 and JURL-MK1 were compared. Imatinib mesylate arrested both cell lines in G0/G1 phase and induced apoptosis that proceeded faster in JURL-MK1 cells and occurred in larger fraction of cell population. In addition, the erythroid differentiation was triggered in both cell lines. Apoptosis and the erythroid differentiation are parallel effects of Imatinib mesylate and their relative contributions and kinetics are related to the differentiation stage of treated cells. Byly porovnány účinky Imatinib mesylátu na CML buněčné linie K562 a JURL-MK1. U obou linií došlo k zastavení buněčného cyklu v G0/G1 fázi a byla indukována apoptoza jež u buněk JURL-MK1 probíhala rychleji a u větší části buněčné populace. Dále byla u obou linií navozena erytroidní diferenciace. Apoptoza a erytroidní diferenciace jsou paralelními účinky Imatinib mesylátu jejichž relativní příspěvky a kinetiky jsou závislé na diferenciačním stavu buněk.
dcterms:title
Fast apoptosis and erythroid differentiation induced by imatinib mesylate in JURL-MK1 cells. Fast apoptosis and erythroid differentiation induced by imatinib mesylate in JURL-MK1 cells. Rychlá apoptóza a erytroidní diferenciace vyvolané účinkem imatinib mesylátu na buněčné linie K 562 a JURL-MK1
skos:prefLabel
Rychlá apoptóza a erytroidní diferenciace vyvolané účinkem imatinib mesylátu na buněčné linie K 562 a JURL-MK1 Fast apoptosis and erythroid differentiation induced by imatinib mesylate in JURL-MK1 cells. Fast apoptosis and erythroid differentiation induced by imatinib mesylate in JURL-MK1 cells.
skos:notation
RIV/00023736:_____/04:I0000035!RIV/2005/MZ0/L33005/N
n3:strany
36
n3:aktivita
n18:P
n3:aktivity
P(NL7681)
n3:dodaniDat
n15:2005
n3:domaciTvurceVysledku
n12:1709615 n12:4073746 n12:3682463
n3:druhVysledku
n9:D
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n4:predkladatel
n3:idSjednocenehoVysledku
564173
n3:idVysledku
RIV/00023736:_____/04:I0000035
n3:jazykVysledku
n7:eng
n3:klicovaSlova
Imatinib mesylate;STI571;leukemia;apoptosis;erythroid differentiation
n3:klicoveSlovo
n8:leukemia n8:STI571 n8:apoptosis n8:erythroid%20differentiation n8:Imatinib%20mesylate
n3:kontrolniKodProRIV
[AAE7D1E3A5C0]
n3:mistoKonaniAkce
Cascais
n3:mistoVydani
Cascais
n3:nazevZdroje
5th interdisciplinary conference mechanisms of cell death and disease : advances in therapeutic intervention and drug development
n3:obor
n11:FD
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
3
n3:projekt
n17:NL7681
n3:rokUplatneniVysledku
n15:2004
n3:tvurceVysledku
Grebeňová, Dana Kuželová, Kateřina Hrkal, Zbyněk
n3:typAkce
n14:EUR
n3:zahajeniAkce
2004-10-22+02:00
s:numberOfPages
1
n19:hasPublisher
ESH and MD Anderson Cancer Center