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Statements

Subject Item
n2:RIV%2F00023728%3A_____%2F10%3A%230000018%21RIV11-MZ0-00023728
rdf:type
skos:Concept n8:Vysledek
dcterms:description
Multipotent adult germ-line stem cells (maGSCs) and induced pluripotent stem cells (iPSCs) could be used to generate autologous cells for therapeutic purposes, which are expected to be tolerated by the recipient. However, effects of the immune system on these cells have not been investigated. In this study, we have compared the susceptibility of maGSC lines to IL-2-activated natural killer (NK) cells with embryonic stem cell (ESC) lines, iPSCs, and F9 teratocarcinoma cells. We found the pluripotent cells to be a very efficient target of syngeneic, allogeneic, and xenogeneic killer cells. The killing of pluripotent cell lines by syngeneic, allogeneic, and xenogeneic killer cells ranged between 48 and 265% in chromium release assays when compared to YAC-1 cells, which served as highly susceptible reference cells. Multipotent adult germ-line stem cells (maGSCs) and induced pluripotent stem cells (iPSCs) could be used to generate autologous cells for therapeutic purposes, which are expected to be tolerated by the recipient. However, effects of the immune system on these cells have not been investigated. In this study, we have compared the susceptibility of maGSC lines to IL-2-activated natural killer (NK) cells with embryonic stem cell (ESC) lines, iPSCs, and F9 teratocarcinoma cells. We found the pluripotent cells to be a very efficient target of syngeneic, allogeneic, and xenogeneic killer cells. The killing of pluripotent cell lines by syngeneic, allogeneic, and xenogeneic killer cells ranged between 48 and 265% in chromium release assays when compared to YAC-1 cells, which served as highly susceptible reference cells.
dcterms:title
Pluripotent stem cells are highly susceptible targets for syngeneic, allogeneic, and xenogeneic natural killer cells Pluripotent stem cells are highly susceptible targets for syngeneic, allogeneic, and xenogeneic natural killer cells
skos:prefLabel
Pluripotent stem cells are highly susceptible targets for syngeneic, allogeneic, and xenogeneic natural killer cells Pluripotent stem cells are highly susceptible targets for syngeneic, allogeneic, and xenogeneic natural killer cells
skos:notation
RIV/00023728:_____/10:#0000018!RIV11-MZ0-00023728
n3:aktivita
n16:V
n3:aktivity
V
n3:cisloPeriodika
7
n3:dodaniDat
n10:2011
n3:domaciTvurceVysledku
n11:5017130
n3:druhVysledku
n13:J
n3:duvernostUdaju
n5:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
279233
n3:idVysledku
RIV/00023728:_____/10:#0000018
n3:jazykVysledku
n12:eng
n3:klicovaSlova
multipotent adult germ-line stem cells; embryonic stem cells; teratomas; cellular cytotoxicity; NK receptor ligands
n3:klicoveSlovo
n4:embryonic%20stem%20cells n4:teratomas n4:cellular%20cytotoxicity n4:NK%20receptor%20ligands n4:multipotent%20adult%20germ-line%20stem%20cells
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[E940015E94BD]
n3:nazevZdroje
FASEB JOURNAL
n3:obor
n7:FE
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
9
n3:rokUplatneniVysledku
n10:2010
n3:svazekPeriodika
24
n3:tvurceVysledku
Guan, K. M. Jaenisch, R. Hasenfuss, G. Novota, Peter Streckfuss-Bomeke, K. Nolte, J. Elsner, L. Engel, W. Dressel, R.
n3:wos
000279343600004
s:issn
0892-6638
s:numberOfPages
14