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Statements

Subject Item
n2:RIV%2F00023728%3A_____%2F09%3A00000097%21RIV10-MZ0-00023728
rdf:type
n9:Vysledek skos:Concept
dcterms:description
The statistically significant reductions compared to baseline in serum PINP and ß-CTx in the SrR group indicate a weak inhibition of bone turnover activity at the dose used in humans and should be taken into account when analyzing the different effects of these two drugs on the bone remodeling cycle using bone biopsies. Changes in microarchitecture induced by SrR in human biopsies cannot be considered as proof of the anabolic effects of this drug, at least at the doses used in humans. These analyses were cross-sectional and not based on paired biopsies. The microstructural differences seen from µCT of iliac bone biopsies from SrR and placebo treated women were very similar to those described with classical antiresorptives such as alendronate and zoledronate in similar cross-sectional analyses The statistically significant reductions compared to baseline in serum PINP and ß-CTx in the SrR group indicate a weak inhibition of bone turnover activity at the dose used in humans and should be taken into account when analyzing the different effects of these two drugs on the bone remodeling cycle using bone biopsies. Changes in microarchitecture induced by SrR in human biopsies cannot be considered as proof of the anabolic effects of this drug, at least at the doses used in humans. These analyses were cross-sectional and not based on paired biopsies. The microstructural differences seen from µCT of iliac bone biopsies from SrR and placebo treated women were very similar to those described with classical antiresorptives such as alendronate and zoledronate in similar cross-sectional analyses
dcterms:title
Response to Comparison of Teriparatide and Strontium Ranelate in Postmenopausal Women with Osteoporosis Response to Comparison of Teriparatide and Strontium Ranelate in Postmenopausal Women with Osteoporosis
skos:prefLabel
Response to Comparison of Teriparatide and Strontium Ranelate in Postmenopausal Women with Osteoporosis Response to Comparison of Teriparatide and Strontium Ranelate in Postmenopausal Women with Osteoporosis
skos:notation
RIV/00023728:_____/09:00000097!RIV10-MZ0-00023728
n3:aktivita
n12:V
n3:aktivity
V
n3:cisloPeriodika
12
n3:dodaniDat
n16:2010
n3:domaciTvurceVysledku
n13:4548779
n3:druhVysledku
n7:J
n3:duvernostUdaju
n11:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
339185
n3:idVysledku
RIV/00023728:_____/09:00000097
n3:jazykVysledku
n14:eng
n3:klicovaSlova
Biological Markers; Bone Remodeling; Osteoporosis; Strontium ranelate; Teriparatide
n3:klicoveSlovo
n6:Biological%20Markers n6:Teriparatide n6:Strontium%20ranelate n6:Osteoporosis n6:Bone%20Remodeling
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[68FC30FC6AB1]
n3:nazevZdroje
Journal of Bone and Mineral Research
n3:obor
n8:FE
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
5
n3:rokUplatneniVysledku
n16:2009
n3:svazekPeriodika
24
n3:tvurceVysledku
Štěpán, Jan Ish-Shalom, S. Marin, F. Hawkins, F. Recker, R. R.
n3:wos
000273216600018
s:issn
0884-0431
s:numberOfPages
2