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Statements

Subject Item
n2:RIV%2F00023001%3A_____%2F14%3A00058834%21RIV15-GA0-00023001
rdf:type
skos:Concept n14:Vysledek
rdfs:seeAlso
http://www.biomedcentral.com/1471-2172/15/4
dcterms:description
Monocytes represent a heterogeneuos population of cells subdivided according to the expression level of membrane antigens. A pro-inflammatory (intermediate/nonclassical) subpopulation of monocytes is defined by expression of CD16. CD163 seems to be characteristically preferentially expressed by immunosuppressive monocytes.The aim of our study was to avaluete the distribution of monocyte subpopulations in 71 patients with kidney allograft transplantation. The phenotype was evaluated by flow cytometry in defined time points. The proportions of peripheral CD14+CD16+ monocytes were downregulated immediately after the kidney transplantation and basiliximab treatment partially attenuated this trend. The transient downregulation of the CD14+CD16+ subpopulation was adjust to basal values in two months. The proportions of CD14+Cd163+ monocytes were transietlyupregulated early after the kidney transplantation and remained higher during the first month in most patients. In ATG treated patients, the expansion of CD14+Cd163+ monocytes was delayd but their upregulation lasted longer. Monocytes represent a heterogeneuos population of cells subdivided according to the expression level of membrane antigens. A pro-inflammatory (intermediate/nonclassical) subpopulation of monocytes is defined by expression of CD16. CD163 seems to be characteristically preferentially expressed by immunosuppressive monocytes.The aim of our study was to avaluete the distribution of monocyte subpopulations in 71 patients with kidney allograft transplantation. The phenotype was evaluated by flow cytometry in defined time points. The proportions of peripheral CD14+CD16+ monocytes were downregulated immediately after the kidney transplantation and basiliximab treatment partially attenuated this trend. The transient downregulation of the CD14+CD16+ subpopulation was adjust to basal values in two months. The proportions of CD14+Cd163+ monocytes were transietlyupregulated early after the kidney transplantation and remained higher during the first month in most patients. In ATG treated patients, the expansion of CD14+Cd163+ monocytes was delayd but their upregulation lasted longer.
dcterms:title
CD14+CD16+and CD14+CD163+monocyte subpopulations in kidney allograft transplantation CD14+CD16+and CD14+CD163+monocyte subpopulations in kidney allograft transplantation
skos:prefLabel
CD14+CD16+and CD14+CD163+monocyte subpopulations in kidney allograft transplantation CD14+CD16+and CD14+CD163+monocyte subpopulations in kidney allograft transplantation
skos:notation
RIV/00023001:_____/14:00058834!RIV15-GA0-00023001
n3:aktivita
n15:P
n3:aktivity
P(GAP301/11/1568)
n3:cisloPeriodika
4
n3:dodaniDat
n5:2015
n3:domaciTvurceVysledku
n4:3684342 n4:1246291 n4:1786385 n4:9762973 n4:7194641 n4:6873472 n4:7354487
n3:druhVysledku
n16:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
6356
n3:idVysledku
RIV/00023001:_____/14:00058834
n3:jazykVysledku
n12:eng
n3:klicovaSlova
CD14+Cd16+, CD14+CD163+, Kidney, Monocytes, Subpopulations, Transplantation
n3:klicoveSlovo
n7:Kidney n7:Subpopulations n7:CD14%2BCD163%2B n7:CD14%2BCd16%2B n7:Monocytes n7:Transplantation
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[487B7DC887E3]
n3:nazevZdroje
BMC IMMUNOLOGY
n3:obor
n8:EC
n3:pocetDomacichTvurcuVysledku
7
n3:pocetTvurcuVysledku
7
n3:projekt
n9:GAP301%2F11%2F1568
n3:rokUplatneniVysledku
n5:2014
n3:svazekPeriodika
15
n3:tvurceVysledku
Lánská, Věra Krepsová, Eva Slatinská, Janka Viklický, Ondřej Sekerková, Alena Brabcová, Eva Stříž, Ilja
n3:wos
000332972400001
s:issn
1471-2172
s:numberOfPages
10
n19:doi
10.1186/1471-2172-15-4