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Statements

Subject Item
n2:RIV%2F00023001%3A_____%2F13%3A00058761%21RIV14-MZ0-00023001
rdf:type
n6:Vysledek skos:Concept
rdfs:seeAlso
http://circheartfailure.ahajournals.org/content/6/5.toc
dcterms:description
Background-Cross-sectional studies suggest that left ventricular (LV) and arterial elastance (stiffness) increase with age, but data examining longitudinal changes within human subjects are lacking. In addition, it remains unknown whether age-related LV stiffening is merely a reaction to arterial stiffening or caused by other processes. Methods and Results-Comprehensive echo-Doppler cardiography was performed in 1402 subjects participating in a randomly selected community-based study at 2 examinations separated by 4 years. From this population, 788 subjects had adequate paired data to determine LV end-systolic elastance (Ees), end-diastolic elastance (Eed), and effective arterial elastance. Throughout 4 years, blood pressure, arterial elastance, and LV mass decreased, coupled with significantly greater use of antihypertensive medications. However, despite reductions in arterial load, Ees increased by 14% (2.10+-0.67-2.26+-0.70 mm Hg/mL; P<0.0001) and Eed increased by 8% (0.13+-0.03-0.14+-0.04 mm Hg/mL; P<0.0001). Increases in Eed were greater in women than men, whereas Ees changes were similar. Age-related increases in Ees and Eed were correlated with changes in body weight, but were similar in subjects with or without cardiovascular disease. Changes in Ees were correlated with Eed (r=0.5; P<0.0001), but not with other measures of contractility, indicating that the increase in Ees was reflective of passive stiffening rather than enhanced systolic function. Conclusions-Despite reductions in arterial load with medical therapy, LV systolic and diastolic stiffness increase over time in humans, particularly in women. In addition to blood pressure control, therapies targeting load-independent ventricular stiffening may be effective to treat and prevent age-associated cardiovascular diseases, such as heart failure. Background-Cross-sectional studies suggest that left ventricular (LV) and arterial elastance (stiffness) increase with age, but data examining longitudinal changes within human subjects are lacking. In addition, it remains unknown whether age-related LV stiffening is merely a reaction to arterial stiffening or caused by other processes. Methods and Results-Comprehensive echo-Doppler cardiography was performed in 1402 subjects participating in a randomly selected community-based study at 2 examinations separated by 4 years. From this population, 788 subjects had adequate paired data to determine LV end-systolic elastance (Ees), end-diastolic elastance (Eed), and effective arterial elastance. Throughout 4 years, blood pressure, arterial elastance, and LV mass decreased, coupled with significantly greater use of antihypertensive medications. However, despite reductions in arterial load, Ees increased by 14% (2.10+-0.67-2.26+-0.70 mm Hg/mL; P<0.0001) and Eed increased by 8% (0.13+-0.03-0.14+-0.04 mm Hg/mL; P<0.0001). Increases in Eed were greater in women than men, whereas Ees changes were similar. Age-related increases in Ees and Eed were correlated with changes in body weight, but were similar in subjects with or without cardiovascular disease. Changes in Ees were correlated with Eed (r=0.5; P<0.0001), but not with other measures of contractility, indicating that the increase in Ees was reflective of passive stiffening rather than enhanced systolic function. Conclusions-Despite reductions in arterial load with medical therapy, LV systolic and diastolic stiffness increase over time in humans, particularly in women. In addition to blood pressure control, therapies targeting load-independent ventricular stiffening may be effective to treat and prevent age-associated cardiovascular diseases, such as heart failure.
dcterms:title
Longitudinal changes in left ventricular stiffness: A Community-Based Study Longitudinal changes in left ventricular stiffness: A Community-Based Study
skos:prefLabel
Longitudinal changes in left ventricular stiffness: A Community-Based Study Longitudinal changes in left ventricular stiffness: A Community-Based Study
skos:notation
RIV/00023001:_____/13:00058761!RIV14-MZ0-00023001
n6:predkladatel
n12:ico%3A00023001
n3:aktivita
n14:N
n3:aktivity
N
n3:cisloPeriodika
5
n3:dodaniDat
n19:2014
n3:domaciTvurceVysledku
n8:4066332
n3:druhVysledku
n17:J
n3:duvernostUdaju
n10:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
85366
n3:idVysledku
RIV/00023001:_____/13:00058761
n3:jazykVysledku
n18:eng
n3:klicovaSlova
aging, arterial stiffness, heart failure, hemodynamics, ventricular function
n3:klicoveSlovo
n16:heart%20failure n16:arterial%20stiffness n16:aging n16:hemodynamics n16:ventricular%20function
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[A1F3B51E61E8]
n3:nazevZdroje
Circulation heart failure
n3:obor
n9:FA
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
7
n3:rokUplatneniVysledku
n19:2013
n3:svazekPeriodika
6
n3:tvurceVysledku
Redfield, MM Melenovský, Vojtěch Jacobsen, S. J. Karon, BL Rodeheffer, R. J. Borlaug, BA Kane, GC
s:issn
1941-3289
s:numberOfPages
9
n15:doi
10.1161/CIRCHEARTFAILURE.113.000383