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Statements

Subject Item
n2:RIV%2F00023001%3A_____%2F13%3A00058727%21RIV14-MZ0-00023001
rdf:type
n8:Vysledek skos:Concept
rdfs:seeAlso
http://www.sciencedirect.com/science/article/pii/S0168822713002209#
dcterms:description
Aims: Diabetes mellitus and decreased renal function are important risk factors for contrast-induced nephropathy (CIN) in which oxidative stress damage may play a role. Alkalinization with sodium bicarbonate (NaHCO3) has been proposed as a means of reducing free-radical mediated renal injury; however, the effectiveness of NaHCO3 treatment to prevent CIN in high-risk patients remains uncertain. Methods: We performed a prospective, randomized, double blind, sodium chloride (NaCl) hydration-controlled study of NaHCO3 in 120 diabetic patients with impaired renal function (serum creatinine >= 100 mu mol/L) undergoing an elective procedure with use of low-osmolar contrast media. The primary endpoint was the incidence of CIN defined as creatinine increase of >= 25% and/or >= 44 mu mol/L within 2 days after contrast. Secondary end-points were maximal changes in serum creatinine and estimated glomerular filtration rate. Urine F2-isoprostane levels were also assessed as measure of oxidative stress. Results: There were no significant group differences in baseline characteristics except for the marginally lower age of the NaHCO3 treated patients (63 +/- 11 vs. 67 +/- 10 years; p = 0.05). CIN occurred in 7 (11.5%) and 5 (8.5%) patients of the NaHCO3 and NaCl groups, respectively (p = 0.76; incidence rate ratio 1.35; 95% CI 0.37-5.41). No significant differences were seen in secondary outcome measures and changes in the parameter of oxidative stress. Conclusions: In diabetic patients with renal function impairment sodium bicarbonate does not confer protection against contrast-induced nephropathy greater than sodium chloride-based hydration. Its specific role in mitigating oxidative stress damage in CIN is also not supported by our data. Aims: Diabetes mellitus and decreased renal function are important risk factors for contrast-induced nephropathy (CIN) in which oxidative stress damage may play a role. Alkalinization with sodium bicarbonate (NaHCO3) has been proposed as a means of reducing free-radical mediated renal injury; however, the effectiveness of NaHCO3 treatment to prevent CIN in high-risk patients remains uncertain. Methods: We performed a prospective, randomized, double blind, sodium chloride (NaCl) hydration-controlled study of NaHCO3 in 120 diabetic patients with impaired renal function (serum creatinine >= 100 mu mol/L) undergoing an elective procedure with use of low-osmolar contrast media. The primary endpoint was the incidence of CIN defined as creatinine increase of >= 25% and/or >= 44 mu mol/L within 2 days after contrast. Secondary end-points were maximal changes in serum creatinine and estimated glomerular filtration rate. Urine F2-isoprostane levels were also assessed as measure of oxidative stress. Results: There were no significant group differences in baseline characteristics except for the marginally lower age of the NaHCO3 treated patients (63 +/- 11 vs. 67 +/- 10 years; p = 0.05). CIN occurred in 7 (11.5%) and 5 (8.5%) patients of the NaHCO3 and NaCl groups, respectively (p = 0.76; incidence rate ratio 1.35; 95% CI 0.37-5.41). No significant differences were seen in secondary outcome measures and changes in the parameter of oxidative stress. Conclusions: In diabetic patients with renal function impairment sodium bicarbonate does not confer protection against contrast-induced nephropathy greater than sodium chloride-based hydration. Its specific role in mitigating oxidative stress damage in CIN is also not supported by our data.
dcterms:title
Prevention of contrast-induced nephropathy in diabetic patients with impaired renal function: a randomized, double blind trial of sodium bicarbonate versus sodium chloride-based hydration Prevention of contrast-induced nephropathy in diabetic patients with impaired renal function: a randomized, double blind trial of sodium bicarbonate versus sodium chloride-based hydration
skos:prefLabel
Prevention of contrast-induced nephropathy in diabetic patients with impaired renal function: a randomized, double blind trial of sodium bicarbonate versus sodium chloride-based hydration Prevention of contrast-induced nephropathy in diabetic patients with impaired renal function: a randomized, double blind trial of sodium bicarbonate versus sodium chloride-based hydration
skos:notation
RIV/00023001:_____/13:00058727!RIV14-MZ0-00023001
n8:predkladatel
n9:ico%3A00023001
n3:aktivita
n12:I
n3:aktivity
I
n3:cisloPeriodika
3
n3:dodaniDat
n15:2014
n3:domaciTvurceVysledku
n6:4930584 n6:1129023 n6:7882092 n6:7814070 n6:1545426 n6:9989196 n6:6829449
n3:druhVysledku
n5:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
99152
n3:idVysledku
RIV/00023001:_____/13:00058727
n3:jazykVysledku
n7:eng
n3:klicovaSlova
Impaired renal function; Diabetes mellitus; Sodium bicarbonate; Contrast-induced nephropathy
n3:klicoveSlovo
n4:Contrast-induced%20nephropathy n4:Diabetes%20mellitus n4:Impaired%20renal%20function n4:Sodium%20bicarbonate
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[239E43AE2CE6]
n3:nazevZdroje
Diabetes research and clinical practice
n3:obor
n13:FB
n3:pocetDomacichTvurcuVysledku
7
n3:pocetTvurcuVysledku
7
n3:rokUplatneniVysledku
n15:2013
n3:svazekPeriodika
101
n3:tvurceVysledku
Bouček, Petr Šarkady, Darina Skibová, Jelena Pučelíková, Tereza Pečenková, Věra Oliyarnyk, Olena Havrdová, Terezia
n3:wos
000325424800012
s:issn
0168-8227
s:numberOfPages
6
n18:doi
10.1016/j.diabres.2013.05.015