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Statements

Subject Item
n2:RIV%2F00023001%3A_____%2F13%3A00058703%21RIV14-MZ0-00023001
rdf:type
skos:Concept n14:Vysledek
rdfs:seeAlso
http://www.hindawi.com/journals/cdi/2013/509259/
dcterms:description
Both antibody mediated (AMR) and T-cell mediated (TCMR) rejections either acute or chronic represent the main reason for late graft dysfunction. In this study we aimed to evaluate differences in the intrarenal expression patterns of immune system related genes in acute and chronic rejections. Graft biopsies were performed and evaluated according to Banff classification. Using the TaqMan Low Density Array, the intrarenal expressions of 376 genes relating to immune response (B-cell activation, T-cell activation, chemokines, growth factors, immune regulators, and apoptosis) were analyzed in the four rejection categories: chronic AMR, chronic TCMR, acute AMR, and acute TCMR. The set of genes significantly upregulated in acute TCMR as compared to acute AMR was identified, while no difference in gene expressions between chronic rejections groups was found. In comparison with functioning grafts, grafts that failed within the next 24 months after the chronic rejection morphological confirmation presented at biopsy already established severe graft injury (low eGFR, higher proteinuria), longer followup, higher expression of CDC20, CXCL6, DIABLO, GABRP, KIAA0101, ME2, MMP7, NFATC4, and TGFB3 mRNA, and lower expression of CCL19 and TRADD mRNA. In conclusion, both Banff 2007 chronic rejection categories did not differ in intrarenal expression of 376 selected genes associated with immune response. Both antibody mediated (AMR) and T-cell mediated (TCMR) rejections either acute or chronic represent the main reason for late graft dysfunction. In this study we aimed to evaluate differences in the intrarenal expression patterns of immune system related genes in acute and chronic rejections. Graft biopsies were performed and evaluated according to Banff classification. Using the TaqMan Low Density Array, the intrarenal expressions of 376 genes relating to immune response (B-cell activation, T-cell activation, chemokines, growth factors, immune regulators, and apoptosis) were analyzed in the four rejection categories: chronic AMR, chronic TCMR, acute AMR, and acute TCMR. The set of genes significantly upregulated in acute TCMR as compared to acute AMR was identified, while no difference in gene expressions between chronic rejections groups was found. In comparison with functioning grafts, grafts that failed within the next 24 months after the chronic rejection morphological confirmation presented at biopsy already established severe graft injury (low eGFR, higher proteinuria), longer followup, higher expression of CDC20, CXCL6, DIABLO, GABRP, KIAA0101, ME2, MMP7, NFATC4, and TGFB3 mRNA, and lower expression of CCL19 and TRADD mRNA. In conclusion, both Banff 2007 chronic rejection categories did not differ in intrarenal expression of 376 selected genes associated with immune response.
dcterms:title
Molecular profiling of acute and chronic rejections of renal allografts Molecular profiling of acute and chronic rejections of renal allografts
skos:prefLabel
Molecular profiling of acute and chronic rejections of renal allografts Molecular profiling of acute and chronic rejections of renal allografts
skos:notation
RIV/00023001:_____/13:00058703!RIV14-MZ0-00023001
n14:predkladatel
n15:ico%3A00023001
n3:aktivita
n8:I
n3:aktivity
I
n3:cisloPeriodika
2013
n3:dodaniDat
n7:2014
n3:domaciTvurceVysledku
n4:7168187 n4:4677323 n4:3684342 n4:9859128 n4:9766782
n3:druhVysledku
n12:J
n3:duvernostUdaju
n6:S
n3:entitaPredkladatele
n10:predkladatel
n3:idSjednocenehoVysledku
89327
n3:idVysledku
RIV/00023001:_____/13:00058703
n3:jazykVysledku
n17:eng
n3:klicovaSlova
molecular profiling; renal allografts; chronic rejections
n3:klicoveSlovo
n11:chronic%20rejections n11:molecular%20profiling n11:renal%20allografts
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[666BF58347D0]
n3:nazevZdroje
Clinical & Developmental Immunology
n3:obor
n19:FE
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
5
n3:rokUplatneniVysledku
n7:2013
n3:svazekPeriodika
2013
n3:tvurceVysledku
Brabcová, Irena Hřibová, Petra Hrubá, Petra Viklický, Ondřej Honsová, Eva
n3:wos
000327056200001
s:issn
1740-2522
s:numberOfPages
7
n18:doi
10.1155/2013/509259