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Statements

Subject Item
n2:RIV%2F00023001%3A_____%2F13%3A00058665%21RIV14-MZ0-00023001
rdf:type
n11:Vysledek skos:Concept
rdfs:seeAlso
http://informahealthcare.com/doi/abs/10.3109/03009742.2012.754939
dcterms:description
Objectives: Alveolar haemorrhage (AH) is a major cause of early death in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). There is a paucity of information regarding the outcomes of AAV patients presenting with severe AH. Method: A retrospective cohort study. Patients with severe AH were identified from a case review of 824 AAV patients. Demography, presenting features, treatment, and outcomes are described. Results: Fifty-three patients (33 males, 20 females; median age 59 years) with severe AH were identified: 37 (69.8%) with granulomatosis with polyangiitis (Wegener's) and 16 with microscopic polyangiitis [36 proteinase 3 (PR3)-ANCA positive and 17 myeloperoxidase (MPO)-ANCA positive]. AH was the first disease manifestation in 46 (86.8%) patients. Assisted ventilation was required in 36 (67.9%), renal involvement was present in 52 (98.1%), and 28 (52.8%) required dialysis. Forty (75.5%) received plasma exchange. At 3 months, 44/53 (83.0%) were alive. The mean follow-up was 49 months when 31 (58.5%) were alive and 24 (45.3%) dialysis independent. Mortality was higher in those requiring dialysis at entry (57.1% vs. 24%, p = 0.02) and in patients aged > 65 years (71.4% vs. 30.8%, p = 0.01), and tended to be higher in those requiring intubation (54.5% vs. 32.2%, p = 0.1). Conclusions: Severe AH was more commonly associated with PR3-ANCA (vs. MPO-ANCA) and strongly correlated with renal vasculitis. Current treatment of severe AH leads to remission but long-term mortality remains high. Concurrent renal failure and older age were associated with higher mortality. Objectives: Alveolar haemorrhage (AH) is a major cause of early death in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). There is a paucity of information regarding the outcomes of AAV patients presenting with severe AH. Method: A retrospective cohort study. Patients with severe AH were identified from a case review of 824 AAV patients. Demography, presenting features, treatment, and outcomes are described. Results: Fifty-three patients (33 males, 20 females; median age 59 years) with severe AH were identified: 37 (69.8%) with granulomatosis with polyangiitis (Wegener's) and 16 with microscopic polyangiitis [36 proteinase 3 (PR3)-ANCA positive and 17 myeloperoxidase (MPO)-ANCA positive]. AH was the first disease manifestation in 46 (86.8%) patients. Assisted ventilation was required in 36 (67.9%), renal involvement was present in 52 (98.1%), and 28 (52.8%) required dialysis. Forty (75.5%) received plasma exchange. At 3 months, 44/53 (83.0%) were alive. The mean follow-up was 49 months when 31 (58.5%) were alive and 24 (45.3%) dialysis independent. Mortality was higher in those requiring dialysis at entry (57.1% vs. 24%, p = 0.02) and in patients aged > 65 years (71.4% vs. 30.8%, p = 0.01), and tended to be higher in those requiring intubation (54.5% vs. 32.2%, p = 0.1). Conclusions: Severe AH was more commonly associated with PR3-ANCA (vs. MPO-ANCA) and strongly correlated with renal vasculitis. Current treatment of severe AH leads to remission but long-term mortality remains high. Concurrent renal failure and older age were associated with higher mortality.
dcterms:title
Long-term outcome of severe alveolar haemorrhage in ANCA-associated vasculitis: a retrospective cohort study Long-term outcome of severe alveolar haemorrhage in ANCA-associated vasculitis: a retrospective cohort study
skos:prefLabel
Long-term outcome of severe alveolar haemorrhage in ANCA-associated vasculitis: a retrospective cohort study Long-term outcome of severe alveolar haemorrhage in ANCA-associated vasculitis: a retrospective cohort study
skos:notation
RIV/00023001:_____/13:00058665!RIV14-MZ0-00023001
n11:predkladatel
n12:ico%3A00023001
n4:aktivita
n10:V n10:Z n10:I
n4:aktivity
I, V, Z(MSM0021620806)
n4:cisloPeriodika
3
n4:dodaniDat
n19:2014
n4:domaciTvurceVysledku
n16:6873472
n4:druhVysledku
n15:J
n4:duvernostUdaju
n14:S
n4:entitaPredkladatele
n13:predkladatel
n4:idSjednocenehoVysledku
85403
n4:idVysledku
RIV/00023001:_____/13:00058665
n4:jazykVysledku
n20:eng
n4:klicovaSlova
wegeners-granulomatosis; microscopic polyangiitis
n4:klicoveSlovo
n8:wegeners-granulomatosis n8:microscopic%20polyangiitis
n4:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n4:kontrolniKodProRIV
[B51C0761E515]
n4:nazevZdroje
Scandinavian journal of rheumatology
n4:obor
n5:FA
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
8
n4:rokUplatneniVysledku
n19:2013
n4:svazekPeriodika
42
n4:tvurceVysledku
Casian, A. L. Frausova, D. Konopasek, P. Hruskova, Z. Tesar, V. Svobodova, B. Lánská, Věra Jayne, D. R. W.
n4:wos
000319036800008
n4:zamer
n18:MSM0021620806
s:issn
0300-9742
s:numberOfPages
4
n17:doi
10.3109/03009742.2012.754939