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Statements

Subject Item
n2:RIV%2F00023001%3A_____%2F13%3A00056090%21RIV14-MZ0-00023001
rdf:type
n5:Vysledek skos:Concept
rdfs:seeAlso
http://ac.els-cdn.com/S0002914912022023/1-s2.0-S0002914912022023-main.pdf?_tid=123884cc-5efe-11e2-baa1-00000aacb35f&acdnat=1358245789_eadee3cffc7a5cb1587badb66ad6d4dd
dcterms:description
We evaluated the clinical utility of cardiac magnetic resonance imaging (CMR) combined with a novel high-sensitivity troponin T assay (hs-cTnT) in the diagnosis of inflammatory cardiomyopathy. CMR, measurement of hs-cTnT, and endomyocardial biopsy were performed in 42 patients with dilated cardiomyopathy and a short-term history of heart failure (median 2 months, interquartile range 1 to 3.5). The patients were followed up for 25 +- 9 months for events. Endomyocardial biopsy revealed myocarditis in 15 subjects (36%). The sensitivity, specificity, and diagnostic accuracy of the individual CMR tissue parameters for myocardial inflammation was 40%, 96%, and 76% for early gadolinium enhancement, 87%, 44%, and 60% for late gadolinium enhancement, 47%, 89%, and 74% for pericardial effusion, and 67%, 85%, and 79% for any 2 of the criteria simultaneously, respectively. An assessment of myocardial edema on T(2)-weighted imaging and/or hs-cTnT assay were inadequate for the diagnosis. The extent of late gadolinium enhancement and increased hs-cTnT concentration were significant predictors of a composite end point of cardiac death, urgent heart transplantation, and hospitalization for worsening heart failure (hazard ratio 1.1, 95% confidence interval 1.0 to 1.2, per percentage of left ventricular mass; and hazard ratio 2.2, 95% confidence interval 1.4 to 3.5, per ln ng/L; p = 0.008 and p = 0.001, respectively). In conclusion, the results of the present study have demonstrated a modest performance for CMR and a limited use of the hs-cTnT assay in the diagnosis of inflammatory cardiomyopathy. Nonetheless, in these patients, CMR and/or hs-cTnT assessment seems to be useful for the prediction of the clinical outcome. We evaluated the clinical utility of cardiac magnetic resonance imaging (CMR) combined with a novel high-sensitivity troponin T assay (hs-cTnT) in the diagnosis of inflammatory cardiomyopathy. CMR, measurement of hs-cTnT, and endomyocardial biopsy were performed in 42 patients with dilated cardiomyopathy and a short-term history of heart failure (median 2 months, interquartile range 1 to 3.5). The patients were followed up for 25 +- 9 months for events. Endomyocardial biopsy revealed myocarditis in 15 subjects (36%). The sensitivity, specificity, and diagnostic accuracy of the individual CMR tissue parameters for myocardial inflammation was 40%, 96%, and 76% for early gadolinium enhancement, 87%, 44%, and 60% for late gadolinium enhancement, 47%, 89%, and 74% for pericardial effusion, and 67%, 85%, and 79% for any 2 of the criteria simultaneously, respectively. An assessment of myocardial edema on T(2)-weighted imaging and/or hs-cTnT assay were inadequate for the diagnosis. The extent of late gadolinium enhancement and increased hs-cTnT concentration were significant predictors of a composite end point of cardiac death, urgent heart transplantation, and hospitalization for worsening heart failure (hazard ratio 1.1, 95% confidence interval 1.0 to 1.2, per percentage of left ventricular mass; and hazard ratio 2.2, 95% confidence interval 1.4 to 3.5, per ln ng/L; p = 0.008 and p = 0.001, respectively). In conclusion, the results of the present study have demonstrated a modest performance for CMR and a limited use of the hs-cTnT assay in the diagnosis of inflammatory cardiomyopathy. Nonetheless, in these patients, CMR and/or hs-cTnT assessment seems to be useful for the prediction of the clinical outcome.
dcterms:title
Utility of combination of cardiac magnetic resonance imaging and high-sensitivity cardiac troponin T assay in diagnosis of inflammatory cardiomyopathy Utility of combination of cardiac magnetic resonance imaging and high-sensitivity cardiac troponin T assay in diagnosis of inflammatory cardiomyopathy
skos:prefLabel
Utility of combination of cardiac magnetic resonance imaging and high-sensitivity cardiac troponin T assay in diagnosis of inflammatory cardiomyopathy Utility of combination of cardiac magnetic resonance imaging and high-sensitivity cardiac troponin T assay in diagnosis of inflammatory cardiomyopathy
skos:notation
RIV/00023001:_____/13:00056090!RIV14-MZ0-00023001
n5:predkladatel
n17:ico%3A00023001
n3:aktivita
n12:P n12:I
n3:aktivity
I, P(NS9697)
n3:cisloPeriodika
2
n3:dodaniDat
n8:2014
n3:domaciTvurceVysledku
n7:4924789 n7:8499608 n7:5202965 n7:9051783 n7:6807437 n7:7989105 n7:4559169
n3:druhVysledku
n6:J
n3:duvernostUdaju
n20:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
113260
n3:idVysledku
RIV/00023001:_____/13:00056090
n3:jazykVysledku
n14:eng
n3:klicovaSlova
cardiovascular magnetic resonance imaging, inflammatory cardiomyopathy, endomyocardial biopsy
n3:klicoveSlovo
n4:cardiovascular%20magnetic%20resonance%20imaging n4:inflammatory%20cardiomyopathy n4:endomyocardial%20biopsy
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[26E4AEC9814B]
n3:nazevZdroje
American Journal of Cardiology
n3:obor
n16:FA
n3:pocetDomacichTvurcuVysledku
7
n3:pocetTvurcuVysledku
8
n3:projekt
n15:NS9697
n3:rokUplatneniVysledku
n8:2013
n3:svazekPeriodika
111
n3:tvurceVysledku
Franeková, Janka Malušková, Jana Weichet, Jiří Kautznerová, Dana Kautzner, Josef Tintěra, Jaroslav Kubánek, Miloš Šramko, Marek
n3:wos
000313607100018
s:issn
0002-9149
s:numberOfPages
7
n10:doi
10.1016/j.amjcard.2012.09.024