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Statements

Subject Item
n2:RIV%2F00023001%3A_____%2F12%3A00056288%21RIV13-MZ0-00023001
rdf:type
skos:Concept n15:Vysledek
rdfs:seeAlso
http://onlinelibrary.wiley.com/doi/10.1111/j.1399-0012.2011.01488.x/full
dcterms:description
Background: BK virus (BKV) replication is considered as a marker of risk for polyomavirus BK-associated nephropathy (PVAN). We evaluated the occurrence and risk factors for BKV DNA positivity following simultaneous pancreas/kidney transplantation (SPK). Methods: Point prevalence of BK viruria and viremia was assessed in 183 SPK recipients. Real-time polymerase chain reaction was used with a detection threshold of 10(3) copies/mL. High-level BKV positivity was defined as viruria and/or viremia > 10(7) and > 10(4) copies/mL, respectively. BKV-positive patients were retested after 4-13 months and underwent an additional six-month clinical follow-up. Results: Urine and serum BKV positivity was detected in 28 (17.3% of available samples) and 7 (3.8%) patients, with high-level viruria and viremia occurring in 6 (3.7%) and 3 (1.6%) patients, respectively. PVAN was biopsy-confirmed in 1 and suspected as a cause of progressive renal failure in another SPK recipient. Patients with single low-level viruria did not progress to high-level positivity or PVAN at follow-up. In multivariate analysis, pre-transplant diabetes duration and delayed graft function were independently associated with BKV positivity. Conclusions: Point prevalence of high-level BKV positivity and PVAN was low in SPK recipients from a single center. Diabetes duration and delayed graft function were independent risk factors for BKV replication. Background: BK virus (BKV) replication is considered as a marker of risk for polyomavirus BK-associated nephropathy (PVAN). We evaluated the occurrence and risk factors for BKV DNA positivity following simultaneous pancreas/kidney transplantation (SPK). Methods: Point prevalence of BK viruria and viremia was assessed in 183 SPK recipients. Real-time polymerase chain reaction was used with a detection threshold of 10(3) copies/mL. High-level BKV positivity was defined as viruria and/or viremia > 10(7) and > 10(4) copies/mL, respectively. BKV-positive patients were retested after 4-13 months and underwent an additional six-month clinical follow-up. Results: Urine and serum BKV positivity was detected in 28 (17.3% of available samples) and 7 (3.8%) patients, with high-level viruria and viremia occurring in 6 (3.7%) and 3 (1.6%) patients, respectively. PVAN was biopsy-confirmed in 1 and suspected as a cause of progressive renal failure in another SPK recipient. Patients with single low-level viruria did not progress to high-level positivity or PVAN at follow-up. In multivariate analysis, pre-transplant diabetes duration and delayed graft function were independently associated with BKV positivity. Conclusions: Point prevalence of high-level BKV positivity and PVAN was low in SPK recipients from a single center. Diabetes duration and delayed graft function were independent risk factors for BKV replication.
dcterms:title
Prevalence and risk factors of polyomavirus BK replication in simultaneous pancreas/kidney transplant recipients from a single transplant center Prevalence and risk factors of polyomavirus BK replication in simultaneous pancreas/kidney transplant recipients from a single transplant center
skos:prefLabel
Prevalence and risk factors of polyomavirus BK replication in simultaneous pancreas/kidney transplant recipients from a single transplant center Prevalence and risk factors of polyomavirus BK replication in simultaneous pancreas/kidney transplant recipients from a single transplant center
skos:notation
RIV/00023001:_____/12:00056288!RIV13-MZ0-00023001
n15:predkladatel
n16:ico%3A00023001
n3:aktivita
n6:I
n3:aktivity
I
n3:cisloPeriodika
2
n3:dodaniDat
n17:2013
n3:domaciTvurceVysledku
n4:4620747 n4:8327173 n4:4930584 n4:8540446 n4:6829449 n4:2002221 n4:8577927
n3:druhVysledku
n8:J
n3:duvernostUdaju
n13:S
n3:entitaPredkladatele
n14:predkladatel
n3:idSjednocenehoVysledku
161468
n3:idVysledku
RIV/00023001:_____/12:00056288
n3:jazykVysledku
n18:eng
n3:klicovaSlova
SPK; risk factors; PVAN; prevalence; BKV
n3:klicoveSlovo
n5:BKV n5:SPK n5:risk%20factors n5:prevalence n5:PVAN
n3:kodStatuVydavatele
DK - Dánské království
n3:kontrolniKodProRIV
[315F1A454A54]
n3:nazevZdroje
Clinical transplantation
n3:obor
n9:FB
n3:pocetDomacichTvurcuVysledku
7
n3:pocetTvurcuVysledku
8
n3:rokUplatneniVysledku
n17:2012
n3:svazekPeriodika
26
n3:tvurceVysledku
Mindlová, Martina Jedináková, Teodora Lipár, Květoslav Hirsch, Hans H Saudek, František Skibová, Jelena Bouček, Petr Adamec, Miloš
n3:wos
000302860400026
s:issn
0902-0063
s:numberOfPages
8
n19:doi
10.1111/j.1399-0012.2011.01488.x