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Statements

Subject Item
n2:RIV%2F00023001%3A_____%2F12%3A00056133%21RIV13-MZ0-00023001
rdf:type
n7:Vysledek skos:Concept
rdfs:seeAlso
http://content.karger.com/produktedb/produkte.asp?DOI=10.1159/000331562
dcterms:description
Background: There are only few studies documenting the long-term outcome of aorto-caval fistula (ACF) in rats, a model of volume overload heart failure (HF). The aim of the present study was to describe HF-related morbidity and mortality, and to examine the relation between cardiac hypertrophy and survival. Methods: Adult male Wistar rats underwent needle ACF or sham operation and 71 animals surviving the acute procedure with patent ACF were followed for 52 weeks. Results: By the end of the study, 72% of the ACF animals deceased and 82% developed HF signs. Of the HF rats, 65% died (median: 3 weeks after HF onset). Before death, body weight increased by 9% followed by a final drop. 28% ACF rats died suddenly, without preceding HF. Sudden death occurred earlier and in the rats with a trend to larger hearts (p = 0.07). In the whole ACF cohort, heart weight (heart weight/body weight ratio) was inversely associated with the length of survival (r = ?0.51, p ! 0.001). Conclusion: The median survival of ACF Wistar rats is 43 weeks, longer than reported in other rat strains. Increased heart weight is associated with higher mortality and a significant number of animals die suddenly. Background: There are only few studies documenting the long-term outcome of aorto-caval fistula (ACF) in rats, a model of volume overload heart failure (HF). The aim of the present study was to describe HF-related morbidity and mortality, and to examine the relation between cardiac hypertrophy and survival. Methods: Adult male Wistar rats underwent needle ACF or sham operation and 71 animals surviving the acute procedure with patent ACF were followed for 52 weeks. Results: By the end of the study, 72% of the ACF animals deceased and 82% developed HF signs. Of the HF rats, 65% died (median: 3 weeks after HF onset). Before death, body weight increased by 9% followed by a final drop. 28% ACF rats died suddenly, without preceding HF. Sudden death occurred earlier and in the rats with a trend to larger hearts (p = 0.07). In the whole ACF cohort, heart weight (heart weight/body weight ratio) was inversely associated with the length of survival (r = ?0.51, p ! 0.001). Conclusion: The median survival of ACF Wistar rats is 43 weeks, longer than reported in other rat strains. Increased heart weight is associated with higher mortality and a significant number of animals die suddenly.
dcterms:title
The course of heart failure development and mortality in rats with volume overload due to aorto-caval fistula The course of heart failure development and mortality in rats with volume overload due to aorto-caval fistula
skos:prefLabel
The course of heart failure development and mortality in rats with volume overload due to aorto-caval fistula The course of heart failure development and mortality in rats with volume overload due to aorto-caval fistula
skos:notation
RIV/00023001:_____/12:00056133!RIV13-MZ0-00023001
n7:predkladatel
n8:ico%3A00023001
n3:aktivita
n18:P n18:I
n3:aktivity
I, P(1M0510), P(GA305/09/1390), P(NS10497)
n3:cisloPeriodika
3
n3:dodaniDat
n10:2013
n3:domaciTvurceVysledku
n4:1111604 n4:6750656 n4:3495795 n4:4066332 n4:7977131 n4:4763610
n3:druhVysledku
n14:J
n3:duvernostUdaju
n11:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
128945
n3:idVysledku
RIV/00023001:_____/12:00056133
n3:jazykVysledku
n20:eng
n3:klicovaSlova
Heart failure, Volume overload, Mortality, Cardiac hypertrophy, Experimental models
n3:klicoveSlovo
n6:Cardiac%20hypertrophy n6:Mortality n6:Volume%20overload n6:Heart%20failure n6:Experimental%20models
n3:kodStatuVydavatele
CH - Švýcarská konfederace
n3:kontrolniKodProRIV
[E1E36FBF9FB4]
n3:nazevZdroje
Kidney and Blood Pressure Research
n3:obor
n17:FA
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
6
n3:projekt
n15:GA305%2F09%2F1390 n15:NS10497 n15:1M0510
n3:rokUplatneniVysledku
n10:2012
n3:svazekPeriodika
35
n3:tvurceVysledku
Červenka, Luděk Kopkan, Libor Beneš, Jan Melenovský, Vojtěch Škaroupková, Petra Torresová, Věra
n3:wos
000303273500005
s:issn
1420-4096
s:numberOfPages
7
n16:doi
10.1159/000331562