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Statements

Subject Item
n2:RIV%2F00023001%3A_____%2F12%3A00056041%21RIV13-MZ0-00023001
rdf:type
n5:Vysledek skos:Concept
rdfs:seeAlso
http://www.sciencedirect.com/science/article/pii/S0010865012000100
dcterms:description
Background: Out-of-hospital cardiac arrest (OHCA) is a leading cause of death and severe neurological disability. The objective of this study was to identify clinical predictors of early neurological outcome in survivors of OHCA managed according to recent recommendations for OHCA care. Methods: Data from survivors of OHCA, admitted to a tertiary cardiac intensive care unit and treated with hypothermia in a 22 months period (n=46, age 60+-13 years, 74% males) were retrospectively evaluated. At 1-month follow-up, patients were classified according to the best achieved Glasgow-Pittsburgh cerebral performance categories (CPC 1-5) and factors affecting the outcome were analysed. Results: At 1-month follow-up, 23 patients (50%) had favourable outcome (CPC 1-2), while 23 patients (50%) had poor outcome (CPC 3-5), including 19 with in-hospital death (41% of total). Patients with good outcome were younger (55+-13 years vs. 66+-10 years; P=0.003), had more often myocardial infarction as the cause of arrest (63% vs. 30%; P=0.018) and ventricular fibrillation/tachycardia as an initial rhythm (78% vs. 39%; P=0.007). Both groups differed by lactate level on admission (4.0+-4.6 vs. 7.3+-4.1 mmol/l, P=0.02), after 12 h (2.5+-1.1 vs. 4.3+-3.2 mmol/l, P=0.04) and after 24 h (1.9+-1.2 vs. 3.2+-1.9 mmol/l, P=0.04). Logistic regression revealed the following independent outcome predictors: age, acute myocardial infarction and admission lactate level. Conclusion: Favourable outcome was observed in a half of OHCA survivors. Young age, acute myocardial infarction as underlying aetiology of cardiac arrest, and low lactate level on admission were the best predictors of favourable outcome. Background: Out-of-hospital cardiac arrest (OHCA) is a leading cause of death and severe neurological disability. The objective of this study was to identify clinical predictors of early neurological outcome in survivors of OHCA managed according to recent recommendations for OHCA care. Methods: Data from survivors of OHCA, admitted to a tertiary cardiac intensive care unit and treated with hypothermia in a 22 months period (n=46, age 60+-13 years, 74% males) were retrospectively evaluated. At 1-month follow-up, patients were classified according to the best achieved Glasgow-Pittsburgh cerebral performance categories (CPC 1-5) and factors affecting the outcome were analysed. Results: At 1-month follow-up, 23 patients (50%) had favourable outcome (CPC 1-2), while 23 patients (50%) had poor outcome (CPC 3-5), including 19 with in-hospital death (41% of total). Patients with good outcome were younger (55+-13 years vs. 66+-10 years; P=0.003), had more often myocardial infarction as the cause of arrest (63% vs. 30%; P=0.018) and ventricular fibrillation/tachycardia as an initial rhythm (78% vs. 39%; P=0.007). Both groups differed by lactate level on admission (4.0+-4.6 vs. 7.3+-4.1 mmol/l, P=0.02), after 12 h (2.5+-1.1 vs. 4.3+-3.2 mmol/l, P=0.04) and after 24 h (1.9+-1.2 vs. 3.2+-1.9 mmol/l, P=0.04). Logistic regression revealed the following independent outcome predictors: age, acute myocardial infarction and admission lactate level. Conclusion: Favourable outcome was observed in a half of OHCA survivors. Young age, acute myocardial infarction as underlying aetiology of cardiac arrest, and low lactate level on admission were the best predictors of favourable outcome.
dcterms:title
Clinical predictors of outcome in survivors of out-of-hospital cardiac arrest treated with hypothermia Clinical predictors of outcome in survivors of out-of-hospital cardiac arrest treated with hypothermia
skos:prefLabel
Clinical predictors of outcome in survivors of out-of-hospital cardiac arrest treated with hypothermia Clinical predictors of outcome in survivors of out-of-hospital cardiac arrest treated with hypothermia
skos:notation
RIV/00023001:_____/12:00056041!RIV13-MZ0-00023001
n5:predkladatel
n6:ico%3A00023001
n8:aktivita
n11:I n11:P
n8:aktivity
I, P(1M0510), P(GA305/09/1390), P(NS10497)
n8:cisloPeriodika
3-4
n8:dodaniDat
n9:2013
n8:domaciTvurceVysledku
n13:1476068 n13:5510155 n13:4066332 n13:6807437
n8:druhVysledku
n14:J
n8:duvernostUdaju
n15:S
n8:entitaPredkladatele
n16:predkladatel
n8:idSjednocenehoVysledku
127437
n8:idVysledku
RIV/00023001:_____/12:00056041
n8:jazykVysledku
n20:eng
n8:klicovaSlova
Out-of-hospital cardiacarrest, Post-cardiopulmonary resuscitation, care, Hypothermia, Predictors ofoutcome
n8:klicoveSlovo
n12:Out-of-hospital%20cardiacarrest n12:Predictors%20ofoutcome n12:care n12:Post-cardiopulmonary%20resuscitation n12:Hypothermia
n8:kodStatuVydavatele
CZ - Česká republika
n8:kontrolniKodProRIV
[13EF00DD0396]
n8:nazevZdroje
Cor et Vasa
n8:obor
n19:FA
n8:pocetDomacichTvurcuVysledku
4
n8:pocetTvurcuVysledku
4
n8:projekt
n17:1M0510 n17:GA305%2F09%2F1390 n17:NS10497
n8:rokUplatneniVysledku
n9:2012
n8:svazekPeriodika
54
n8:tvurceVysledku
Kettner, Jiří Melenovský, Vojtěch Aldhoon, Bashar Kautzner, Josef
s:issn
0010-8650
s:numberOfPages
8
n4:doi
10.1016/j.crvasa.2012.01.005