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Statements

Subject Item
n2:RIV%2F00023001%3A_____%2F12%3A00055832%21RIV13-MZ0-00023001
rdf:type
n10:Vysledek skos:Concept
rdfs:seeAlso
http://ntr.oxfordjournals.org/content/14/8/998.long
dcterms:description
Introduction: Using genome-wide screening, a polymorphism within the second intron of the FTO gene (rs2302673) was found to be associated with smoking habits in females. In a population-based, cross-sectional study, we analyzed three tagging FTO single-nucleotide polymorphisms (SNPs) for their association with smoking behavior. Methods: Subjects from the Czech post-MONICA study, including 1,191 adult males (32.1% smokers) and 1,368 adult females (22.5% smokers) were included in this study. Smoking habits were obtained through questionnaire data analysis, and three FTO tagging SNPs were genotyped (rs17817449: intron 1, rs2302673: intron 2, and rs17818902: intron 3). Results: We detected slightly lower frequencies (p = .043) of the GG genotype of the rs17818902 SNP in males who quit smoking compared with others. However, the significance disappeared after adjusting for multiple testing. Within the entire population, or in either males or females alone, we failed to detect a significant difference between other FTO genotypes and smoking status. Also, the number of cigarettes smoked per day was independent of individual FTO genotypes in both genders. Conclusions: We did not find an association between the FTO gene tagging variants and smoking status. FTO is unlikely to be a major genetic determinant of smoking status. Introduction: Using genome-wide screening, a polymorphism within the second intron of the FTO gene (rs2302673) was found to be associated with smoking habits in females. In a population-based, cross-sectional study, we analyzed three tagging FTO single-nucleotide polymorphisms (SNPs) for their association with smoking behavior. Methods: Subjects from the Czech post-MONICA study, including 1,191 adult males (32.1% smokers) and 1,368 adult females (22.5% smokers) were included in this study. Smoking habits were obtained through questionnaire data analysis, and three FTO tagging SNPs were genotyped (rs17817449: intron 1, rs2302673: intron 2, and rs17818902: intron 3). Results: We detected slightly lower frequencies (p = .043) of the GG genotype of the rs17818902 SNP in males who quit smoking compared with others. However, the significance disappeared after adjusting for multiple testing. Within the entire population, or in either males or females alone, we failed to detect a significant difference between other FTO genotypes and smoking status. Also, the number of cigarettes smoked per day was independent of individual FTO genotypes in both genders. Conclusions: We did not find an association between the FTO gene tagging variants and smoking status. FTO is unlikely to be a major genetic determinant of smoking status.
dcterms:title
Lack of an Association Between Three Tagging SNPs Within the FTO Gene and Smoking Behavior Lack of an Association Between Three Tagging SNPs Within the FTO Gene and Smoking Behavior
skos:prefLabel
Lack of an Association Between Three Tagging SNPs Within the FTO Gene and Smoking Behavior Lack of an Association Between Three Tagging SNPs Within the FTO Gene and Smoking Behavior
skos:notation
RIV/00023001:_____/12:00055832!RIV13-MZ0-00023001
n10:predkladatel
n16:ico%3A00023001
n3:aktivita
n20:I n20:P
n3:aktivity
I, P(NT12170)
n3:cisloPeriodika
8
n3:dodaniDat
n14:2013
n3:domaciTvurceVysledku
n6:6513832 n6:3241513 n6:6873472 n6:4176456
n3:druhVysledku
n18:J
n3:duvernostUdaju
n8:S
n3:entitaPredkladatele
n4:predkladatel
n3:idSjednocenehoVysledku
146337
n3:idVysledku
RIV/00023001:_____/12:00055832
n3:jazykVysledku
n15:eng
n3:klicovaSlova
BMI; mass; genotype; dependence; risk; variant; population; obesity; Cigarette-smoking
n3:klicoveSlovo
n7:obesity n7:population n7:variant n7:mass n7:BMI n7:dependence n7:Cigarette-smoking n7:risk n7:genotype
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[139B0E7A7BF2]
n3:nazevZdroje
Nicotine & tobacco research
n3:obor
n17:EB
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:projekt
n19:NT12170
n3:rokUplatneniVysledku
n14:2012
n3:svazekPeriodika
14
n3:tvurceVysledku
Lánská, Věra Dlouhá, Dana Adámková, Věra Hubáček, Jaroslav
n3:wos
000307430700015
s:issn
1462-2203
s:numberOfPages
5
n12:doi
10.1093/ntr/ntr255