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Statements

Subject Item
n2:RIV%2F00023001%3A_____%2F12%3A00055831%21RIV13-MZ0-00023001
rdf:type
skos:Concept n8:Vysledek
rdfs:seeAlso
http://onlinelibrary.wiley.com/doi/10.1002/jmri.23599/abstract;jsessionid=DE9D7588F719B27089FDD7B2D68285A9.d03t04
dcterms:description
PURPOSE: To examine changes in the brain before liver transplantation caused by the accumulation of paramagnetic ion deposits and to investigate recovery after liver transplantation over a long-term horizon. MATERIALS AND METHODS: Fifteen patients indicated for liver transplantation, 26 patients up to 2 years after, and 40 patients 8-15 years after liver transplantation were subjected to MR relaxometry. T(1) and T(2) relaxation times in the basal ganglia, thalamus, and white matter were evaluated. RESULTS: Relaxometry revealed a shortening of the relaxation times due to the deposition of paramagnetic ions in the basal ganglia before liver transplantation (P < 0.05), complete normalization of the relaxation times shortly after transplantation in the globus pallidus and caudate nucleus, and partial recovery of T(2) in the putamen. Relaxation times remained stable even 15 years posttransplantation. Increased relaxation times posttransplantation were found in the white matter and thalamus. CONCLUSION: The shortening of the relaxation times observed in the basal ganglia before liver transplantation was caused by paramagnetic ion deposition. The recovery observable within 2 years after transplantation was permanent, and no recurrence of paramagnetic ion deposition was observed even 15 years posttransplantation. Changes in the white matter and thalamus after transplantation were attributed to damage caused by permanent exposure to immunosuppressants. PURPOSE: To examine changes in the brain before liver transplantation caused by the accumulation of paramagnetic ion deposits and to investigate recovery after liver transplantation over a long-term horizon. MATERIALS AND METHODS: Fifteen patients indicated for liver transplantation, 26 patients up to 2 years after, and 40 patients 8-15 years after liver transplantation were subjected to MR relaxometry. T(1) and T(2) relaxation times in the basal ganglia, thalamus, and white matter were evaluated. RESULTS: Relaxometry revealed a shortening of the relaxation times due to the deposition of paramagnetic ions in the basal ganglia before liver transplantation (P < 0.05), complete normalization of the relaxation times shortly after transplantation in the globus pallidus and caudate nucleus, and partial recovery of T(2) in the putamen. Relaxation times remained stable even 15 years posttransplantation. Increased relaxation times posttransplantation were found in the white matter and thalamus. CONCLUSION: The shortening of the relaxation times observed in the basal ganglia before liver transplantation was caused by paramagnetic ion deposition. The recovery observable within 2 years after transplantation was permanent, and no recurrence of paramagnetic ion deposition was observed even 15 years posttransplantation. Changes in the white matter and thalamus after transplantation were attributed to damage caused by permanent exposure to immunosuppressants.
dcterms:title
Changes in the brain during long-term follow-up after liver transplantation Changes in the brain during long-term follow-up after liver transplantation
skos:prefLabel
Changes in the brain during long-term follow-up after liver transplantation Changes in the brain during long-term follow-up after liver transplantation
skos:notation
RIV/00023001:_____/12:00055831!RIV13-MZ0-00023001
n8:predkladatel
n9:ico%3A00023001
n3:aktivita
n17:P n17:Z
n3:aktivity
P(NS10523), Z(MZ0IKEM2005)
n3:cisloPeriodika
6
n3:dodaniDat
n10:2013
n3:domaciTvurceVysledku
n11:9828648 n11:2747448 n11:6325823 n11:7395973 n11:6665160
n3:druhVysledku
n12:J
n3:duvernostUdaju
n21:S
n3:entitaPredkladatele
n4:predkladatel
n3:idSjednocenehoVysledku
126707
n3:idVysledku
RIV/00023001:_____/12:00055831
n3:jazykVysledku
n13:eng
n3:klicovaSlova
MR relaxometry; hepatic encephalopathy; brain; liver transplantation; hepatic cirrhosis
n3:klicoveSlovo
n5:liver%20transplantation n5:brain n5:MR%20relaxometry n5:hepatic%20cirrhosis n5:hepatic%20encephalopathy
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[921E503F76DD]
n3:nazevZdroje
Journal of magnetic resonance imaging
n3:obor
n15:FJ
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
5
n3:projekt
n14:NS10523
n3:rokUplatneniVysledku
n10:2012
n3:svazekPeriodika
35
n3:tvurceVysledku
Dezortová, Monika Wagnerová, Dita Herynek, Vít Hájek, Milan Hejlová, Irena
n3:wos
000304035100009
n3:zamer
n16:MZ0IKEM2005
s:issn
1053-1807
s:numberOfPages
6
n18:doi
10.1002/jmri.23599