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Statements

Subject Item
n2:RIV%2F00023001%3A_____%2F11%3A00002723%21RIV12-MZ0-00023001
rdf:type
n16:Vysledek skos:Concept
rdfs:seeAlso
http://www.biomed.cas.cz/physiolres/pdf/60/60_769.pdf
dcterms:description
Pulmonary hypertension (PH) unresponsive to pharmacological intervention is considered a contraindication for orthotopic heart transplantation (OHTX) due to risk of postoperative right-heart failure. In this prospective study, we describe our experience with a treatment strategy of improving severe PH in heart transplant candidates by means of ventricular assist device (VAD) implantation and subsequent OHTX. In 11 heart transplantation candidates with severe PH unresponsive to pharmacological intervention we implanted VAD with the aim of achieving PH to values acceptable for OHTX. In all patients we observed significant drop in pulmonary pressures, PVR and TPG (p<0.001 for all) 3 months after VAD implantation to values sufficient to allow OHTX. Seven patients underwent transplantation (mean duration of support 216 days) while none of patients suffered right-side heart failure in postoperative period. Two patients died after transplantation and five patients are living in very good condition with a mean duration of 286 days after OHTX. In our opinion, severe PH is not a contraindication for orthotopic heart transplantation any more. Pulmonary hypertension (PH) unresponsive to pharmacological intervention is considered a contraindication for orthotopic heart transplantation (OHTX) due to risk of postoperative right-heart failure. In this prospective study, we describe our experience with a treatment strategy of improving severe PH in heart transplant candidates by means of ventricular assist device (VAD) implantation and subsequent OHTX. In 11 heart transplantation candidates with severe PH unresponsive to pharmacological intervention we implanted VAD with the aim of achieving PH to values acceptable for OHTX. In all patients we observed significant drop in pulmonary pressures, PVR and TPG (p<0.001 for all) 3 months after VAD implantation to values sufficient to allow OHTX. Seven patients underwent transplantation (mean duration of support 216 days) while none of patients suffered right-side heart failure in postoperative period. Two patients died after transplantation and five patients are living in very good condition with a mean duration of 286 days after OHTX. In our opinion, severe PH is not a contraindication for orthotopic heart transplantation any more.
dcterms:title
Is severe pulmonary hypertension a contraindication for orthotopic heart transplantation? Not any more Is severe pulmonary hypertension a contraindication for orthotopic heart transplantation? Not any more
skos:prefLabel
Is severe pulmonary hypertension a contraindication for orthotopic heart transplantation? Not any more Is severe pulmonary hypertension a contraindication for orthotopic heart transplantation? Not any more
skos:notation
RIV/00023001:_____/11:00002723!RIV12-MZ0-00023001
n16:predkladatel
n18:ico%3A00023001
n3:aktivita
n12:I
n3:aktivity
I
n3:cisloPeriodika
5
n3:dodaniDat
n4:2012
n3:domaciTvurceVysledku
n5:5510155 n5:6807437 n5:8472882 n5:4066332 n5:3750744 n5:9540628 n5:3523314 n5:7041713 n5:7308159 n5:1190288 n5:5581710
n3:druhVysledku
n11:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
205874
n3:idVysledku
RIV/00023001:_____/11:00002723
n3:jazykVysledku
n6:eng
n3:klicovaSlova
Pulmonary hypertension; Hemodynamics; Heart transplant candidacy; Ventricular assist devices
n3:klicoveSlovo
n10:Hemodynamics n10:Ventricular%20assist%20devices n10:Heart%20transplant%20candidacy n10:Pulmonary%20hypertension
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[42B414D1E2F9]
n3:nazevZdroje
Physiological research
n3:obor
n15:FA
n3:pocetDomacichTvurcuVysledku
11
n3:pocetTvurcuVysledku
11
n3:rokUplatneniVysledku
n4:2011
n3:svazekPeriodika
60
n3:tvurceVysledku
Kettner, Jiří Skalský, Ivo Říha, Hynek Al-Hiti, Hikmet Melenovský, Vojtěch Kautzner, Josef Dorazilová, Zora Pirk, Jan Malý, Jiří Málek, Ivan Netuka, Ivan
n3:wos
000298159900006
s:issn
0862-8408
s:numberOfPages
7