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Statements

Subject Item
n2:RIV%2F00023001%3A_____%2F11%3A00002557%21RIV12-MZ0-00023001
rdf:type
n8:Vysledek skos:Concept
rdfs:seeAlso
http://www.nature.com/hr/journal/v34/n3/full/hr2010232a.html
dcterms:description
The study was aimed at investigating the arterial stiffness assessed by aortic pulse wave velocity (PWV) in the presence of primary hyperparathyroidism (PH), with and without concomitant hypertension. Subsequently, we examined the effect of parathyroidectomy (PTX) on arterial stiffness. A total of 28 patients with PH and concomitant hypertension, and 16 with PH without hypertension were investigated in comparison with 28 essential hypertensive patients and 18 healthy controls, respectively. Patients were matched for age, blood pressure (BP), body mass index, lipid profile and fasting glucose. Six months after PTX, 15 patients were examined again (hypertensive as well as normotensive). PWV was obtained using the SphygmoCor applanation tonometer (AtCor Medical, West Ryde, Australia). PWV was significantly higher in patients with PH and hypertension when compared with patients with essential hypertension (10.1 vs. 8.5ms(-1), P=0.013). PWV remained significant even after adjustment for age and BP (P=0.02). Similarly, PWV was significantly higher in PH patients without hypertension in comparison with healthy controls (7.6 vs. 5.8ms(-1), P < 0.001). Six months after surgery, in addition to a normalization of calcium metabolism, a significant decrease in systolic BP (131 vs. 123 mm Hg, P=0.004) and PWV (9.1 vs. 8.5ms(-1), P=0.024) was observed. After adjusting for BP reduction, the decrease in PWV appeared non-significant. Our data indicate that PH increases PWV as a marker of arterial stiffness, in both hypertensive and non-hypertensive patients. However, neither the calcium serum level nor the parathyroid hormone level has been associated with PWV. Specific treatment by PTX significantly decreases PWV, which may be determined primarily by improved BP control after surgery. The study was aimed at investigating the arterial stiffness assessed by aortic pulse wave velocity (PWV) in the presence of primary hyperparathyroidism (PH), with and without concomitant hypertension. Subsequently, we examined the effect of parathyroidectomy (PTX) on arterial stiffness. A total of 28 patients with PH and concomitant hypertension, and 16 with PH without hypertension were investigated in comparison with 28 essential hypertensive patients and 18 healthy controls, respectively. Patients were matched for age, blood pressure (BP), body mass index, lipid profile and fasting glucose. Six months after PTX, 15 patients were examined again (hypertensive as well as normotensive). PWV was obtained using the SphygmoCor applanation tonometer (AtCor Medical, West Ryde, Australia). PWV was significantly higher in patients with PH and hypertension when compared with patients with essential hypertension (10.1 vs. 8.5ms(-1), P=0.013). PWV remained significant even after adjustment for age and BP (P=0.02). Similarly, PWV was significantly higher in PH patients without hypertension in comparison with healthy controls (7.6 vs. 5.8ms(-1), P < 0.001). Six months after surgery, in addition to a normalization of calcium metabolism, a significant decrease in systolic BP (131 vs. 123 mm Hg, P=0.004) and PWV (9.1 vs. 8.5ms(-1), P=0.024) was observed. After adjusting for BP reduction, the decrease in PWV appeared non-significant. Our data indicate that PH increases PWV as a marker of arterial stiffness, in both hypertensive and non-hypertensive patients. However, neither the calcium serum level nor the parathyroid hormone level has been associated with PWV. Specific treatment by PTX significantly decreases PWV, which may be determined primarily by improved BP control after surgery.
dcterms:title
Pulse wave velocity in primary hyperparathyroidism and effect of surgical therapy Pulse wave velocity in primary hyperparathyroidism and effect of surgical therapy
skos:prefLabel
Pulse wave velocity in primary hyperparathyroidism and effect of surgical therapy Pulse wave velocity in primary hyperparathyroidism and effect of surgical therapy
skos:notation
RIV/00023001:_____/11:00002557!RIV12-MZ0-00023001
n8:predkladatel
n15:ico%3A00023001
n4:aktivita
n14:I n14:V n14:Z
n4:aktivity
I, V, Z(MSM0021620807)
n4:cisloPeriodika
3
n4:dodaniDat
n5:2012
n4:domaciTvurceVysledku
n9:5317010
n4:druhVysledku
n13:J
n4:duvernostUdaju
n10:S
n4:entitaPredkladatele
n20:predkladatel
n4:idSjednocenehoVysledku
225258
n4:idVysledku
RIV/00023001:_____/11:00002557
n4:jazykVysledku
n17:eng
n4:klicovaSlova
arterial stiffness; primary hyperparathyroidism; pulse wave velocity
n4:klicoveSlovo
n12:arterial%20stiffness n12:primary%20hyperparathyroidism n12:pulse%20wave%20velocity
n4:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n4:kontrolniKodProRIV
[19F165A7EB28]
n4:nazevZdroje
Hypertension research
n4:obor
n7:FA
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
9
n4:rokUplatneniVysledku
n5:2011
n4:svazekPeriodika
34
n4:tvurceVysledku
Widimsky, J. Jr Somloova, Z. Holaj, R. Wichterle, Dan Raška, I. Jr Zelinka, T. Strauch, B. Rosa, J. Petrak, O.
n4:wos
000288068300006
n4:zamer
n19:MSM0021620807
s:issn
0916-9636
s:numberOfPages
5
n18:doi
10.1038/hr.2010.232