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Statements

Subject Item
n2:RIV%2F00023001%3A_____%2F11%3A00002532%21RIV14-MZ0-00023001
rdf:type
n13:Vysledek skos:Concept
rdfs:seeAlso
http://cpr.sagepub.com/content/18/6/790.long
dcterms:description
BACKGROUND: Ankle brachial index (ABI) has been increasingly used in general practice to identify individuals with low ABI at high cardiovascular risk. However, there has been no consensus on the clinical significance of high ABI. The aim of our study was to compare aortic stiffness as a marker of cardiovascular risk in individuals with low (<1.0), normal (1.0-1.4), and high ABI (>1.4). METHODS: A total of 911 individuals from the Czech post-MONICA study (a randomly selected 1% representative population sample, aged 54&#8201;?&#8201;13.5 years, 47% of men) were examined. ABI was measured using a handheld Doppler and aortic pulse wave velocity (aPWV) using the Sphygmocor device. RESULTS: Of the 911 individuals, 28 (3.1%) had low ABI and 23 (2.5%) high ABI. There was a U-shaped association between aPWV and ABI. aPWV was significantly higher in individuals with low and high ABI compared with the normal ABI group (11.1&#8201;?&#8201;2.8, 8.3&#8201;?&#8201;2.3, p&#8201;<&#8201;0.001; 10.8&#8201;?&#8201;2.5, 8.3&#8201;?&#8201;2.3&#8201;m/s, p&#8201;<&#8201;0.001, respectively). In a model adjusted for age, sex, systolic, diastolic, mean blood pressure and examiner, aPWV remained increased in both extreme ABI groups compared with the normal ABI group. In logistic regression analysis, aPWV together with glucose level, male sex, and a history of deep venous thrombosis were independent predictors of high ABI, while cholesterol was not. CONCLUSION: This is the first study showing increased aortic stiffness in individuals with high ABI, presumably responsible for increased left ventricular mass described previously in this group. These findings suggest increased cardiovascular risk of high ABI individuals. BACKGROUND: Ankle brachial index (ABI) has been increasingly used in general practice to identify individuals with low ABI at high cardiovascular risk. However, there has been no consensus on the clinical significance of high ABI. The aim of our study was to compare aortic stiffness as a marker of cardiovascular risk in individuals with low (<1.0), normal (1.0-1.4), and high ABI (>1.4). METHODS: A total of 911 individuals from the Czech post-MONICA study (a randomly selected 1% representative population sample, aged 54&#8201;?&#8201;13.5 years, 47% of men) were examined. ABI was measured using a handheld Doppler and aortic pulse wave velocity (aPWV) using the Sphygmocor device. RESULTS: Of the 911 individuals, 28 (3.1%) had low ABI and 23 (2.5%) high ABI. There was a U-shaped association between aPWV and ABI. aPWV was significantly higher in individuals with low and high ABI compared with the normal ABI group (11.1&#8201;?&#8201;2.8, 8.3&#8201;?&#8201;2.3, p&#8201;<&#8201;0.001; 10.8&#8201;?&#8201;2.5, 8.3&#8201;?&#8201;2.3&#8201;m/s, p&#8201;<&#8201;0.001, respectively). In a model adjusted for age, sex, systolic, diastolic, mean blood pressure and examiner, aPWV remained increased in both extreme ABI groups compared with the normal ABI group. In logistic regression analysis, aPWV together with glucose level, male sex, and a history of deep venous thrombosis were independent predictors of high ABI, while cholesterol was not. CONCLUSION: This is the first study showing increased aortic stiffness in individuals with high ABI, presumably responsible for increased left ventricular mass described previously in this group. These findings suggest increased cardiovascular risk of high ABI individuals.
dcterms:title
A high ankle-brachial index is associated with increased aortic pulse wave velocity: the Czech post-MONICA study. A high ankle-brachial index is associated with increased aortic pulse wave velocity: the Czech post-MONICA study.
skos:prefLabel
A high ankle-brachial index is associated with increased aortic pulse wave velocity: the Czech post-MONICA study. A high ankle-brachial index is associated with increased aortic pulse wave velocity: the Czech post-MONICA study.
skos:notation
RIV/00023001:_____/11:00002532!RIV14-MZ0-00023001
n13:predkladatel
n19:ico%3A00023001
n3:aktivita
n10:R n10:P n10:I
n3:aktivity
I, P(NR9389), R
n3:cisloPeriodika
6
n3:dodaniDat
n15:2014
n3:domaciTvurceVysledku
n8:2790726 n8:6953069 n8:6361579 n8:1847589 n8:3597253 n8:8395489 n8:4176456 n8:8576068
n3:druhVysledku
n5:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n12:predkladatel
n3:idSjednocenehoVysledku
183840
n3:idVysledku
RIV/00023001:_____/11:00002532
n3:jazykVysledku
n6:eng
n3:klicovaSlova
pulse wave velocity; high ankle-brachial index; Arterial stiffness
n3:klicoveSlovo
n4:pulse%20wave%20velocity n4:Arterial%20stiffness n4:high%20ankle-brachial%20index
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[653A46FA0463]
n3:nazevZdroje
European journal of cardiovascular prevention and rehabilitation
n3:obor
n17:FA
n3:pocetDomacichTvurcuVysledku
8
n3:pocetTvurcuVysledku
11
n3:projekt
n14:NR9389
n3:rokUplatneniVysledku
n15:2011
n3:svazekPeriodika
18
n3:tvurceVysledku
Bruthans, Jan Wohlfahrt, Peter Palouš, Daniel Cífková, Renata Krajčoviechová, Alena Seidlerová, J. Galovcová, Markéta Ingrischová, M. Filipovský, J. Adámková, Věra Jozífová, Marie
n3:wos
000297975200002
s:issn
1741-8267
s:numberOfPages
7
n20:doi
10.1177/1741826711398840