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Statements

Subject Item
n2:RIV%2F00023001%3A_____%2F11%3A00002511%21RIV12-MZ0-00023001
rdf:type
skos:Concept n12:Vysledek
rdfs:seeAlso
http://www.ingentaconnect.com/content/ben/cvp/2011/00000009/00000003/art00002?token=004e1753eae82075c5f3b3b47464c483f3b627049762f245a4f582a2f433e402c3568263c2be1e
dcterms:description
Background/Aim: Triglycerides (TGs) are measured in studies evaluating changes in non-fasting lipid profiles after a fat tolerance test (FTT); however, the optimal timing for TG measurements after the oral fat load is unclear. The aim of this study was to evaluate how non-fasting TG levels vary after an oral FTT in healthy subjects. Methods: This meta-analysis included 113 studies with >5 participants of Caucasian race that were indexed in PubMed from its inception through March 2010, using the search term %22postprandial lipemia%22. We only included studies that provided mean values and standard deviation (SD) (or standard error of the mean) for TG measurements at baseline (=fasting) and for at least one other time-point. Exclusion criteria included uncommon sampling time-points after the FTT, baseline TGs >= 2.0 mmol/L (>= 177mg/dl), and a body mass index >= 30kg/m(2). Results: All studies combined, weighted mean +/- SD TG values in mmol/L were 1.25 +/- 0.32 fasting, 1.82 +/- 0.40 at 2 h, 2.31 +/- 0.62 at 4 h, 1.87 +/- 0.63 at 6 h, and 1.69 +/- 0.80 at 8 h. After stratifying studies based on fat quantity in the test meal (<40, >= 40-<50, >= 50-<60, <60-<70, >= 70-<80, >= 80-<90, >= 90-<100,>= 100-<110, >= 110-120, >= 120 g), the highest standardized mean difference in TG levels from fasting levels was found in those having an oral fat load of >= 70 g and <80 g, and at 4 h (difference=1.74 mmol/L; p<0.001). Conclusion: The 4 h time-point after an oral fat load during a FTT was the most representative measurement of TGs. The highest standardized mean difference of TGs was found after a meal containing 70-79g of fat. The relevance of these two key parameters determined in healthy subjects should be considered for further developments of an oral FFT for clinical purposes. Background/Aim: Triglycerides (TGs) are measured in studies evaluating changes in non-fasting lipid profiles after a fat tolerance test (FTT); however, the optimal timing for TG measurements after the oral fat load is unclear. The aim of this study was to evaluate how non-fasting TG levels vary after an oral FTT in healthy subjects. Methods: This meta-analysis included 113 studies with >5 participants of Caucasian race that were indexed in PubMed from its inception through March 2010, using the search term %22postprandial lipemia%22. We only included studies that provided mean values and standard deviation (SD) (or standard error of the mean) for TG measurements at baseline (=fasting) and for at least one other time-point. Exclusion criteria included uncommon sampling time-points after the FTT, baseline TGs >= 2.0 mmol/L (>= 177mg/dl), and a body mass index >= 30kg/m(2). Results: All studies combined, weighted mean +/- SD TG values in mmol/L were 1.25 +/- 0.32 fasting, 1.82 +/- 0.40 at 2 h, 2.31 +/- 0.62 at 4 h, 1.87 +/- 0.63 at 6 h, and 1.69 +/- 0.80 at 8 h. After stratifying studies based on fat quantity in the test meal (<40, >= 40-<50, >= 50-<60, <60-<70, >= 70-<80, >= 80-<90, >= 90-<100,>= 100-<110, >= 110-120, >= 120 g), the highest standardized mean difference in TG levels from fasting levels was found in those having an oral fat load of >= 70 g and <80 g, and at 4 h (difference=1.74 mmol/L; p<0.001). Conclusion: The 4 h time-point after an oral fat load during a FTT was the most representative measurement of TGs. The highest standardized mean difference of TGs was found after a meal containing 70-79g of fat. The relevance of these two key parameters determined in healthy subjects should be considered for further developments of an oral FFT for clinical purposes.
dcterms:title
Diagnostic value of postprandial triglyceride testing in healthy subjects: a meta-analysis Diagnostic value of postprandial triglyceride testing in healthy subjects: a meta-analysis
skos:prefLabel
Diagnostic value of postprandial triglyceride testing in healthy subjects: a meta-analysis Diagnostic value of postprandial triglyceride testing in healthy subjects: a meta-analysis
skos:notation
RIV/00023001:_____/11:00002511!RIV12-MZ0-00023001
n12:predkladatel
n13:ico%3A00023001
n4:aktivita
n10:Z
n4:aktivity
Z(MZ0IKEM2005)
n4:cisloPeriodika
3
n4:dodaniDat
n6:2012
n4:domaciTvurceVysledku
n20:7753403
n4:druhVysledku
n17:J
n4:duvernostUdaju
n14:S
n4:entitaPredkladatele
n9:predkladatel
n4:idSjednocenehoVysledku
194214
n4:idVysledku
RIV/00023001:_____/11:00002511
n4:jazykVysledku
n19:eng
n4:klicovaSlova
Fat tolerance test; meta-analysis; postprandial lipaemia; standardized mean difference; triglycerides
n4:klicoveSlovo
n5:triglycerides n5:postprandial%20lipaemia n5:meta-analysis n5:Fat%20tolerance%20test n5:standardized%20mean%20difference
n4:kodStatuVydavatele
AE - Stát Spojené arabské emiráty
n4:kontrolniKodProRIV
[6A5DBC13ED32]
n4:nazevZdroje
Current vascular pharmacology
n4:obor
n16:FB
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
11
n4:rokUplatneniVysledku
n6:2011
n4:svazekPeriodika
9
n4:tvurceVysledku
Mihas, Constantinos Nordestgaard, Borge G Ooi, Teik Chye Anagnostopoulou, Katherine Bilianou, Helen Panotopoulos, George Kolovou, Genovefa D Kovář, Jan Lairon, Dennis Mikhailidis, Dimitri P Perez-Martinez, Pablo
n4:wos
000290656600002
n4:zamer
n8:MZ0IKEM2005
s:issn
1570-1611
s:numberOfPages
10
n7:doi
10.2174/157016111795495530