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Statements

Subject Item
n2:RIV%2F00023001%3A_____%2F11%3A00002510%21RIV12-MZ0-00023001
rdf:type
n5:Vysledek skos:Concept
dcterms:description
OBJECTIVES: Life expectancy is determined by a combination of genetic predisposition (~25%) and environmental influences (~75%). Nevertheless a stronger genetic influence is anticipated in long-living individuals. Apolipoprotein E (APOE) gene belongs among the most studied candidate genes of longevity. We evaluated the relation of APOE polymorphism and fitness status in the elderly. MATERIAL AND METHODS: We examined a total number of 128 subjects, over 80 years of age. Using a battery of functional tests their fitness status was assessed and the subjects were stratified into 5 functional categories according to Spirduso´s classification. Biochemistry analysis was performed by enzymatic method using automated analyzers. APOE gene polymorphism was analysed performed using PCR-RFLP. RESULTS: APOE4 allele carriers had significantly worse fitness status compared to non-carriers (p=0.025). Multiple logistic regression analysis showed the APOE4 carriers had higher risk (p=0.05) of functional unfitness compared to APOE2/E3 individuals. CONCLUSIONS: APOE gene polymorphism seems be an important genetic contributor to frailty development in the elderly. While APOE2 carriers tend to remain functionally fit till higher age, the functional status of APOE4 carriers deteriorates more rapidly. OBJECTIVES: Life expectancy is determined by a combination of genetic predisposition (~25%) and environmental influences (~75%). Nevertheless a stronger genetic influence is anticipated in long-living individuals. Apolipoprotein E (APOE) gene belongs among the most studied candidate genes of longevity. We evaluated the relation of APOE polymorphism and fitness status in the elderly. MATERIAL AND METHODS: We examined a total number of 128 subjects, over 80 years of age. Using a battery of functional tests their fitness status was assessed and the subjects were stratified into 5 functional categories according to Spirduso´s classification. Biochemistry analysis was performed by enzymatic method using automated analyzers. APOE gene polymorphism was analysed performed using PCR-RFLP. RESULTS: APOE4 allele carriers had significantly worse fitness status compared to non-carriers (p=0.025). Multiple logistic regression analysis showed the APOE4 carriers had higher risk (p=0.05) of functional unfitness compared to APOE2/E3 individuals. CONCLUSIONS: APOE gene polymorphism seems be an important genetic contributor to frailty development in the elderly. While APOE2 carriers tend to remain functionally fit till higher age, the functional status of APOE4 carriers deteriorates more rapidly.
dcterms:title
APOE polymorphism as a potential determinant of functional fitness in the elderly regardless of nutritional status APOE polymorphism as a potential determinant of functional fitness in the elderly regardless of nutritional status
skos:prefLabel
APOE polymorphism as a potential determinant of functional fitness in the elderly regardless of nutritional status APOE polymorphism as a potential determinant of functional fitness in the elderly regardless of nutritional status
skos:notation
RIV/00023001:_____/11:00002510!RIV12-MZ0-00023001
n5:predkladatel
n6:ico%3A00023001
n3:aktivita
n13:I n13:P
n3:aktivity
I, P(NT11307)
n3:cisloPeriodika
suppl. 2
n3:dodaniDat
n11:2012
n3:domaciTvurceVysledku
n16:6873472
n3:druhVysledku
n14:J
n3:duvernostUdaju
n10:S
n3:entitaPredkladatele
n4:predkladatel
n3:idSjednocenehoVysledku
186705
n3:idVysledku
RIV/00023001:_____/11:00002510
n3:jazykVysledku
n18:eng
n3:klicovaSlova
apolipoprotein E; life expectancy; gene polymorphism; functional fitness; frailty
n3:klicoveSlovo
n9:gene%20polymorphism n9:apolipoprotein%20E n9:frailty n9:functional%20fitness n9:life%20expectancy
n3:kodStatuVydavatele
SE - Švédské království
n3:kontrolniKodProRIV
[BD24D6FC9BA5]
n3:nazevZdroje
Neuroendocrinology letters
n3:obor
n15:FA
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
10
n3:projekt
n17:NT11307
n3:rokUplatneniVysledku
n11:2011
n3:svazekPeriodika
32
n3:tvurceVysledku
Kalvach, Z. Lánská, Věra Topinkova, E. Prusikova, M. Ceska, R. Zlatohlavek, L. Prochazkova, R. Snejdrlova, M. Kvasilova, M. Vrablik, M.
n3:wos
000300544200012
s:issn
0172-780X
s:numberOfPages
4