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Statements

Subject Item
n2:RIV%2F00023001%3A_____%2F11%3A00002504%21RIV12-MZ0-00023001
rdf:type
n6:Vysledek skos:Concept
dcterms:description
OBJECTIVES: Obesity is associated with increased inflammation which represents a link to atherosclerosis and cardiovascular disease. Lipoprotein associated phospholipase A2 (Lp-PLA2) is an independent marker of inflammation and atherosclerosis risk. To assess the impact of weight loss on metabolic markers of atherosclerosis including Lp-PLA2 we examined a group of Czech non-diabetic obese/overweight children exposed to a lifestyle intervention. PATIENTS AND METHODS: Fourty unrelated overweight/obese non-diabetic Czech children (13.7 ? 2.1 years, average BMI at baseline 29.8 ? 2.6 kg/m2) underwent 4 weeks of lifestyle modification (reduction of energy intake to age matched optimum and supervised physical activity). Anthropometrical and biochemical variables were determined at baseline and after the intervention. Lp-PLA2 mass concentration was assessed using the ELISA kit. Wilcocson´s rank test and Spearman´s correlation were used for statistical analysis. RESULTS: A significant decrease of BMI and waist circumference was associated with significant changes of plasma lipoprotein and glycaemia levels. Mass concentration of Lp-PLA2 at the baseline was 402 ? 94 μg/ml, after the intervention 368 ? 105 μg/ml (p=0.008). Change in Lp-PLA2 was associated with triglyceride level decrease (p=0.009). CONCLUSION: Intensive lifestyle modification leading to body weight decrease results in significant changes of plasma lipoprotein levels and, also, a drop of Lp-PLA2 levels in paediatric obese patients. However, even after the intervention Lp-PLA2 concentrations in this patient group remain elevated suggesting possible increased atherosclerosis risk in later life. OBJECTIVES: Obesity is associated with increased inflammation which represents a link to atherosclerosis and cardiovascular disease. Lipoprotein associated phospholipase A2 (Lp-PLA2) is an independent marker of inflammation and atherosclerosis risk. To assess the impact of weight loss on metabolic markers of atherosclerosis including Lp-PLA2 we examined a group of Czech non-diabetic obese/overweight children exposed to a lifestyle intervention. PATIENTS AND METHODS: Fourty unrelated overweight/obese non-diabetic Czech children (13.7 ? 2.1 years, average BMI at baseline 29.8 ? 2.6 kg/m2) underwent 4 weeks of lifestyle modification (reduction of energy intake to age matched optimum and supervised physical activity). Anthropometrical and biochemical variables were determined at baseline and after the intervention. Lp-PLA2 mass concentration was assessed using the ELISA kit. Wilcocson´s rank test and Spearman´s correlation were used for statistical analysis. RESULTS: A significant decrease of BMI and waist circumference was associated with significant changes of plasma lipoprotein and glycaemia levels. Mass concentration of Lp-PLA2 at the baseline was 402 ? 94 μg/ml, after the intervention 368 ? 105 μg/ml (p=0.008). Change in Lp-PLA2 was associated with triglyceride level decrease (p=0.009). CONCLUSION: Intensive lifestyle modification leading to body weight decrease results in significant changes of plasma lipoprotein levels and, also, a drop of Lp-PLA2 levels in paediatric obese patients. However, even after the intervention Lp-PLA2 concentrations in this patient group remain elevated suggesting possible increased atherosclerosis risk in later life.
dcterms:title
Lifestyle modification induced weight loss and changes of cardiometabolic risk factors including lowering of inflammatory response in obese children Lifestyle modification induced weight loss and changes of cardiometabolic risk factors including lowering of inflammatory response in obese children
skos:prefLabel
Lifestyle modification induced weight loss and changes of cardiometabolic risk factors including lowering of inflammatory response in obese children Lifestyle modification induced weight loss and changes of cardiometabolic risk factors including lowering of inflammatory response in obese children
skos:notation
RIV/00023001:_____/11:00002504!RIV12-MZ0-00023001
n6:predkladatel
n7:ico%3A00023001
n3:aktivita
n5:P n5:V n5:I
n3:aktivity
I, P(NS10589), V
n3:cisloPeriodika
suppl. 2
n3:dodaniDat
n11:2012
n3:domaciTvurceVysledku
n14:6873472
n3:druhVysledku
n10:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
209534
n3:idVysledku
RIV/00023001:_____/11:00002504
n3:jazykVysledku
n9:eng
n3:klicovaSlova
obesity; atherosclerosis; cardiovascular risk; children; lipoprotein associated phospholipase A2 (Lp-PLA2); weight loss
n3:klicoveSlovo
n4:lipoprotein%20associated%20phospholipase%20A2%20%28Lp-PLA2%29 n4:weight%20loss n4:children n4:obesity n4:atherosclerosis n4:cardiovascular%20risk
n3:kodStatuVydavatele
SE - Švédské království
n3:kontrolniKodProRIV
[0AD3222083E5]
n3:nazevZdroje
Neuroendocrinology letters
n3:obor
n15:FB
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
7
n3:projekt
n17:NS10589
n3:rokUplatneniVysledku
n11:2011
n3:svazekPeriodika
32
n3:tvurceVysledku
Vasickova, L. Motykova, E. Lánská, Věra Ceska, R. Prusikova, M. Zlatohlavek, L. Vrablik, M.
n3:wos
000300544200013
s:issn
0172-780X
s:numberOfPages
5