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Statements

Subject Item
n2:RIV%2F00023001%3A_____%2F11%3A00002502%21RIV12-MZ0-00023001
rdf:type
n9:Vysledek skos:Concept
dcterms:description
OBJECTIVES: The AHSG (alpha2 Heremans-Schmid glycoprotein) gene is suggested to be important for the regulation of body fat and insulin sensitivity. Our study aimed to investigate the relationship between the common Thr248Met (rs4917) variant and obesity characteristics after an intervention with overweight females. MATERIAL AND METHODS: We analyzed 105 unrelated overweight/obese nondiabetic Czech adult females (49.0 ? 12.1 years, BMI over 28.6 kg/m2, mean BMI before intervention 32.8 ? 4.1 kg/m2) before and after 10 weeks of lifestyle modification. Biochemical and anthropometrical measurements were performed. The life style modification program consisted of a reduction of energy intake to an age-adjusted optimum and an exercise program (four units per week). The mean weight loss was 3.2 ? 3.5 kg (3.7 ? 4.0%). RESULTS: Thr/Thr homozygotes (N=52) increased lean muscle mass (p<0.05), decreased total body fat (kg) (p<0.005) and increased basal metabolic rate (BMR) per 1 kg body weight (p<0.005) in comparison with the Met carriers (N=52), but an association between BMI decrease and AHSG variants was not found. CONCLUSION: AHSG gene variants modify the effect of physical activity on BMR. Carriers of the Thr248Thr genotype showed a higher benefit from the lifestyle intervention (expressed as changes in body fat, active muscle and basal metabolic rate). OBJECTIVES: The AHSG (alpha2 Heremans-Schmid glycoprotein) gene is suggested to be important for the regulation of body fat and insulin sensitivity. Our study aimed to investigate the relationship between the common Thr248Met (rs4917) variant and obesity characteristics after an intervention with overweight females. MATERIAL AND METHODS: We analyzed 105 unrelated overweight/obese nondiabetic Czech adult females (49.0 ? 12.1 years, BMI over 28.6 kg/m2, mean BMI before intervention 32.8 ? 4.1 kg/m2) before and after 10 weeks of lifestyle modification. Biochemical and anthropometrical measurements were performed. The life style modification program consisted of a reduction of energy intake to an age-adjusted optimum and an exercise program (four units per week). The mean weight loss was 3.2 ? 3.5 kg (3.7 ? 4.0%). RESULTS: Thr/Thr homozygotes (N=52) increased lean muscle mass (p<0.05), decreased total body fat (kg) (p<0.005) and increased basal metabolic rate (BMR) per 1 kg body weight (p<0.005) in comparison with the Met carriers (N=52), but an association between BMI decrease and AHSG variants was not found. CONCLUSION: AHSG gene variants modify the effect of physical activity on BMR. Carriers of the Thr248Thr genotype showed a higher benefit from the lifestyle intervention (expressed as changes in body fat, active muscle and basal metabolic rate).
dcterms:title
An AHSG gene variant modulates basal metabolic rate and body composition development after a short-time lifestyle intervention An AHSG gene variant modulates basal metabolic rate and body composition development after a short-time lifestyle intervention
skos:prefLabel
An AHSG gene variant modulates basal metabolic rate and body composition development after a short-time lifestyle intervention An AHSG gene variant modulates basal metabolic rate and body composition development after a short-time lifestyle intervention
skos:notation
RIV/00023001:_____/11:00002502!RIV12-MZ0-00023001
n9:predkladatel
n18:ico%3A00023001
n3:aktivita
n13:P
n3:aktivity
P(NS10513)
n3:cisloPeriodika
suppl. 2
n3:dodaniDat
n12:2012
n3:domaciTvurceVysledku
n10:6513832 n10:7886543 n10:3776956 n10:1917315 n10:6873472
n3:druhVysledku
n7:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
185393
n3:idVysledku
RIV/00023001:_____/11:00002502
n3:jazykVysledku
n8:eng
n3:klicovaSlova
AHSG polymorphism; lifestyle modification; basal metabolic rate; overweight
n3:klicoveSlovo
n4:overweight n4:basal%20metabolic%20rate n4:AHSG%20polymorphism n4:lifestyle%20modification
n3:kodStatuVydavatele
SE - Švédské království
n3:kontrolniKodProRIV
[9306B974C6DE]
n3:nazevZdroje
Neuroendocrinology letters
n3:obor
n17:FB
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
5
n3:projekt
n15:NS10513
n3:rokUplatneniVysledku
n12:2011
n3:svazekPeriodika
32
n3:tvurceVysledku
Králová Lesná, Ivana Suchánek, Pavel Hubáček, Jaroslav Lánská, Věra Poledne, Rudolf
n3:wos
000300544200009
s:issn
0172-780X
s:numberOfPages
5