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Statements

Subject Item
n2:RIV%2F00023001%3A_____%2F11%3A00002499%21RIV12-MZ0-00023001
rdf:type
skos:Concept n9:Vysledek
dcterms:description
The INSIG2 (INSIG2 is primarily involved in the regulation of fatty acid and cholesterol synthesis) gene is suggested to be obesity related. An INSIG2 promoter variant, G-102A, has been detected and was demonstrated to be of potential functional significance. In two cohorts of middle-aged men, the association between this variant and BMI was suggested. We sought to replicate the association between the INSIG2 G-102A variant and BMI in three large Slavonic Caucasian populations. Further, we analysed the possible effect of this variant on BMI changes in a short-time intervention study. One thousand ninety-nine males and 1368 females (population-based Czech MONICA three-year cohort), 908 females from the 3PMFs study, together with 94 overweight (BMI > 27 kg/m(2)) females who underwent nine weeks of dietary/exercise intervention were genotyped for the INSIG2 G-102A variant using PCR-RFLP analysis. We could not detect any association between the INSIG2 G-102A variant and BMI or WHR with or without adjusting for age and gender in any population. Neither the BMI change nor anthropometric and lipid parameter changes were affected by the INSIG2 G-102A gene variant in intervened overweight females. However, MONICA females (but not males) carrying the common GG genotype had higher plasma levels of HDL cholesterol (GG homozygotes 1.51 +/- 0.36 mmol/l vs. A allele carriers 1.45 +/- 0.33; P < 0.05) in both surveys. Our results indicated that the G-102A INSIG2 polymorphism has no consistent effect on BMI in general populations, but could influence HDL cholesterol in females. The INSIG2 (INSIG2 is primarily involved in the regulation of fatty acid and cholesterol synthesis) gene is suggested to be obesity related. An INSIG2 promoter variant, G-102A, has been detected and was demonstrated to be of potential functional significance. In two cohorts of middle-aged men, the association between this variant and BMI was suggested. We sought to replicate the association between the INSIG2 G-102A variant and BMI in three large Slavonic Caucasian populations. Further, we analysed the possible effect of this variant on BMI changes in a short-time intervention study. One thousand ninety-nine males and 1368 females (population-based Czech MONICA three-year cohort), 908 females from the 3PMFs study, together with 94 overweight (BMI > 27 kg/m(2)) females who underwent nine weeks of dietary/exercise intervention were genotyped for the INSIG2 G-102A variant using PCR-RFLP analysis. We could not detect any association between the INSIG2 G-102A variant and BMI or WHR with or without adjusting for age and gender in any population. Neither the BMI change nor anthropometric and lipid parameter changes were affected by the INSIG2 G-102A gene variant in intervened overweight females. However, MONICA females (but not males) carrying the common GG genotype had higher plasma levels of HDL cholesterol (GG homozygotes 1.51 +/- 0.36 mmol/l vs. A allele carriers 1.45 +/- 0.33; P < 0.05) in both surveys. Our results indicated that the G-102A INSIG2 polymorphism has no consistent effect on BMI in general populations, but could influence HDL cholesterol in females.
dcterms:title
INSIG2 G-102A promoter variant exhibits context-dependent effect on HDL-cholesterol levels but not on BMI in caucasians INSIG2 G-102A promoter variant exhibits context-dependent effect on HDL-cholesterol levels but not on BMI in caucasians
skos:prefLabel
INSIG2 G-102A promoter variant exhibits context-dependent effect on HDL-cholesterol levels but not on BMI in caucasians INSIG2 G-102A promoter variant exhibits context-dependent effect on HDL-cholesterol levels but not on BMI in caucasians
skos:notation
RIV/00023001:_____/11:00002499!RIV12-MZ0-00023001
n9:predkladatel
n10:ico%3A00023001
n3:aktivita
n11:Z n11:P
n3:aktivity
P(1M0510), P(NS10511), P(NS10513), Z(MZ0IKEM2005)
n3:cisloPeriodika
4
n3:dodaniDat
n12:2012
n3:domaciTvurceVysledku
n7:8692548 n7:4176456 n7:6513832 n7:1917315 n7:6873472
n3:druhVysledku
n14:J
n3:duvernostUdaju
n13:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
205028
n3:idVysledku
RIV/00023001:_____/11:00002499
n3:jazykVysledku
n18:eng
n3:klicovaSlova
weight reduction; plasma lipids; obesity; association; protein
n3:klicoveSlovo
n15:protein n15:association n15:obesity n15:plasma%20lipids n15:weight%20reduction
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[7B0319EDDF5F]
n3:nazevZdroje
Folia biologica (Praha)
n3:obor
n17:FB
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
5
n3:projekt
n4:NS10511 n4:NS10513 n4:1M0510
n3:rokUplatneniVysledku
n12:2011
n3:svazekPeriodika
57
n3:tvurceVysledku
Lánská, Věra Hubáček, Jaroslav Adámková, Věra Piťha, Jan Suchánek, Pavel
n3:wos
000295701300006
n3:zamer
n5:MZ0IKEM2005
s:issn
0015-5500
s:numberOfPages
3