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Statements

Subject Item
n2:RIV%2F00023001%3A_____%2F11%3A00002487%21RIV12-MZ0-00023001
rdf:type
n5:Vysledek skos:Concept
rdfs:seeAlso
http://onlinelibrary.wiley.com/doi/10.1111/j.1464-5491.2010.03192.x/full
dcterms:description
The incidence of minor amputation may vary significantly, and determinants of minor amputation have not been studied systematically. We evaluated minor amputation rate, the determinants of minor amputation and differences in amputation rate between European centres. Methods: In the Eurodiale study, a prospective cohort study of 1232 patients (1088 followed until end-point) with a new diabetic foot ulcer were followed on a monthly basis until healing, death, major amputation or up to a maximum of 1 year. Ulcers were treated according to international guidelines. Baseline characteristics independently associated with minor amputation were examined using multiple logistic regression modelling. Based on the results of the multivariable analysis, a disease severity score was calculated for each patient. Results: One hundred and ninety-four (18%) patients underwent a minor amputation. Predictors of minor amputation were depth of the ulcer (odds ratio 6.08, confidence interval 4.10-9.03), peripheral arterial disease (odds ratio 1.84, confidence interval 1.30-2.60), infection (odds ratio 1.56, confidence interval 1.05-2.30) and male sex (odds ratio 1.42, confidence interval 0.99-2.04). Minor amputation rate varied between 2.4 and 34% in the centres. Minor amputation rate in centres correlated strongly with disease severity score at the moment of presentation to the foot clinic (r = 0.75). Conclusions: Minor amputation is performed frequently in diabetic foot centres throughout Europe and is determined by depth of the ulcer, peripheral arterial disease, infection and male sex. There are important differences in amputation rate between the European centres, which can be explained in part by severity of disease at presentation. This may suggest that early referral to foot clinics can prevent minor amputations. The incidence of minor amputation may vary significantly, and determinants of minor amputation have not been studied systematically. We evaluated minor amputation rate, the determinants of minor amputation and differences in amputation rate between European centres. Methods: In the Eurodiale study, a prospective cohort study of 1232 patients (1088 followed until end-point) with a new diabetic foot ulcer were followed on a monthly basis until healing, death, major amputation or up to a maximum of 1 year. Ulcers were treated according to international guidelines. Baseline characteristics independently associated with minor amputation were examined using multiple logistic regression modelling. Based on the results of the multivariable analysis, a disease severity score was calculated for each patient. Results: One hundred and ninety-four (18%) patients underwent a minor amputation. Predictors of minor amputation were depth of the ulcer (odds ratio 6.08, confidence interval 4.10-9.03), peripheral arterial disease (odds ratio 1.84, confidence interval 1.30-2.60), infection (odds ratio 1.56, confidence interval 1.05-2.30) and male sex (odds ratio 1.42, confidence interval 0.99-2.04). Minor amputation rate varied between 2.4 and 34% in the centres. Minor amputation rate in centres correlated strongly with disease severity score at the moment of presentation to the foot clinic (r = 0.75). Conclusions: Minor amputation is performed frequently in diabetic foot centres throughout Europe and is determined by depth of the ulcer, peripheral arterial disease, infection and male sex. There are important differences in amputation rate between the European centres, which can be explained in part by severity of disease at presentation. This may suggest that early referral to foot clinics can prevent minor amputations.
dcterms:title
Differences in minor amputation rate in diabetic foot disease throughout Europe are in part explained by differences in disease severity at presentation Differences in minor amputation rate in diabetic foot disease throughout Europe are in part explained by differences in disease severity at presentation
skos:prefLabel
Differences in minor amputation rate in diabetic foot disease throughout Europe are in part explained by differences in disease severity at presentation Differences in minor amputation rate in diabetic foot disease throughout Europe are in part explained by differences in disease severity at presentation
skos:notation
RIV/00023001:_____/11:00002487!RIV12-MZ0-00023001
n5:predkladatel
n6:ico%3A00023001
n4:aktivita
n14:N
n4:aktivity
N
n4:cisloPeriodika
2
n4:dodaniDat
n17:2012
n4:domaciTvurceVysledku
n18:2334798
n4:druhVysledku
n9:J
n4:duvernostUdaju
n16:S
n4:entitaPredkladatele
n8:predkladatel
n4:idSjednocenehoVysledku
194559
n4:idVysledku
RIV/00023001:_____/11:00002487
n4:jazykVysledku
n10:eng
n4:klicovaSlova
diabetes; foot ulcer; infection; minor amputation; peripheral arterial disease
n4:klicoveSlovo
n13:diabetes n13:infection n13:minor%20amputation n13:foot%20ulcer n13:peripheral%20arterial%20disease
n4:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n4:kontrolniKodProRIV
[84A385DDC3B7]
n4:nazevZdroje
Diabetic medicine
n4:obor
n7:FB
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
19
n4:rokUplatneniVysledku
n17:2011
n4:svazekPeriodika
28
n4:tvurceVysledku
Jude, E. Huijberts, M. Tennvall, R. G. Holstein, P. van Battum, P. Uccioli, L. Piaggesi, A. Ferreira, I. Urbancic, V. Edmonds, M. Reike, H. Schaper, N. Prompers, L. van Acker, K. Jirkovská, Alexandra Spraul, M. Apelqvist, J. van Baal, J. Bakker, K.
n4:wos
000286107000013
s:issn
0742-3071
s:numberOfPages
7
n11:doi
10.1111/j.1464-5491.2010.03192.x