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Statements

Subject Item
n2:RIV%2F00023001%3A_____%2F11%3A00002476%21RIV12-MZ0-00023001
rdf:type
skos:Concept n9:Vysledek
rdfs:seeAlso
http://www.sciencedirect.com/science/article/pii/S1090379811000110
dcterms:description
BACKGROUND: Narcolepsy is a life-long disease characterized by abnormal regulation of the sleep-wake cycle and increased penetration of rapid eye movement (REM) sleep. In children, narcolepsy without cataplexy is more frequently seen than in adults. The aim of our study was to evaluate clinical and polysomnographic parameters to verify if cataplexy appearing later in life can be foretold. METHODS: 30 patients (12 boys), who contracted narcolepsy before the age of 18, were enrolled. All underwent clinical examination, nocturnal polysomnography (PSG), multiple sleep latency test (MSLT), HLA-DQB1*0602 testing and, most of them Epworth Sleepiness Scale (ESS) rating. The Mann-Whitney rank and Fisher's tests were used for statistical analysis. RESULTS: Narcolepsy without cataplexy (NwC) was diagnosed in 40% of the patients. The mean age at the first symptoms was 14.0 ? 3.0, at diagnosis 15.6 ? 3.1 years. Narcolepsy was accompanied by hypnagogic hallucinations in 15 and sleep paralysis in 12 patients. Frequent symptoms were sleep inertia during awakening, REM behavior symptoms, behavioral and serious school problems. BMI was higher in patients with narcolepsy-cataplexy (N-C). A high ESS score was indicative of excessive daytime sleepiness (17.1 ? 2.5). Mean MSLT sleep latency was 4.0 ? 3.1 min with 3.2 ? 1.4 sleep onset REM periods (SOREMs) with no difference between the two study groups. HLA typing revealed no differences either. The N-C group showed a higher degree of wakefulness and superficial non-REM (NREM) stage 1 with a lower NREM stage 3 during PSG. BACKGROUND: Narcolepsy is a life-long disease characterized by abnormal regulation of the sleep-wake cycle and increased penetration of rapid eye movement (REM) sleep. In children, narcolepsy without cataplexy is more frequently seen than in adults. The aim of our study was to evaluate clinical and polysomnographic parameters to verify if cataplexy appearing later in life can be foretold. METHODS: 30 patients (12 boys), who contracted narcolepsy before the age of 18, were enrolled. All underwent clinical examination, nocturnal polysomnography (PSG), multiple sleep latency test (MSLT), HLA-DQB1*0602 testing and, most of them Epworth Sleepiness Scale (ESS) rating. The Mann-Whitney rank and Fisher's tests were used for statistical analysis. RESULTS: Narcolepsy without cataplexy (NwC) was diagnosed in 40% of the patients. The mean age at the first symptoms was 14.0 ? 3.0, at diagnosis 15.6 ? 3.1 years. Narcolepsy was accompanied by hypnagogic hallucinations in 15 and sleep paralysis in 12 patients. Frequent symptoms were sleep inertia during awakening, REM behavior symptoms, behavioral and serious school problems. BMI was higher in patients with narcolepsy-cataplexy (N-C). A high ESS score was indicative of excessive daytime sleepiness (17.1 ? 2.5). Mean MSLT sleep latency was 4.0 ? 3.1 min with 3.2 ? 1.4 sleep onset REM periods (SOREMs) with no difference between the two study groups. HLA typing revealed no differences either. The N-C group showed a higher degree of wakefulness and superficial non-REM (NREM) stage 1 with a lower NREM stage 3 during PSG.
dcterms:title
Clinical features of childhood narcolepsy. Can cataplexy be foretold? Clinical features of childhood narcolepsy. Can cataplexy be foretold?
skos:prefLabel
Clinical features of childhood narcolepsy. Can cataplexy be foretold? Clinical features of childhood narcolepsy. Can cataplexy be foretold?
skos:notation
RIV/00023001:_____/11:00002476!RIV12-MZ0-00023001
n9:predkladatel
n18:ico%3A00023001
n3:aktivita
n4:Z n4:I n4:V
n3:aktivity
I, V, Z(MSM0021620849)
n3:cisloPeriodika
4
n3:dodaniDat
n19:2012
n3:domaciTvurceVysledku
n20:6829449
n3:druhVysledku
n11:J
n3:duvernostUdaju
n8:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
190611
n3:idVysledku
RIV/00023001:_____/11:00002476
n3:jazykVysledku
n16:eng
n3:klicovaSlova
Childhood narcolepsy; Cataplexy; Clinical features; Multiple sleep latency test; Polysomnography
n3:klicoveSlovo
n5:Clinical%20features n5:Childhood%20narcolepsy n5:Multiple%20sleep%20latency%20test n5:Cataplexy n5:Polysomnography
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[416A29A835E2]
n3:nazevZdroje
European journal of paediatric neurology
n3:obor
n17:FH
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
6
n3:rokUplatneniVysledku
n19:2011
n3:svazekPeriodika
15
n3:tvurceVysledku
Jara, C. Sonka, K. Kemlink, D. Skibová, Jelena Prihodova, I. Nevsimalova, S.
n3:wos
000296670400007
n3:zamer
n12:MSM0021620849
s:issn
1090-3798
s:numberOfPages
6
n15:doi
10.1016/j.ejpn.2011.01.008